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Immobilization with Ketamine HCI and Tiletamine-Zolazepam in Cynomolgus Monkeys
Myung-cheol Kim,Sung-hyeok Hong,Soo-jin Lee,Young-suk Kim,Jae-il Lee 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
with Ketamine HCl and Tiletamine-Zolazepam in Cynomolgus MonkeysJae-il Lee, Sung-hyeok Hong, Soo-jin Lee, Young-suk Kim and Myung-cheol Kim*Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, KoreaReceived March 4, 2003 / Accepted July 2, 2003J. Vet. Sci. (2003), 4(2), 187-191JOURNAL OFVeterinaryScience*Corresponding author: Myung-cheol Kim Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea Tel: +82-42-821-6757, Fax: +82-42-822-4216 E-mail: mckim@cnu.ac.kr
Production of Bio-Based Isoprene by the Mevalonate Pathway Cassette in Ralstonia eutropha
( Hyeok-won Lee ),( Jung-ho Park ),( Hee-seok Lee ),( Wonho Choi ),( Sung-hwa Seo ),( Irika Devi Anggraini ),( Eui-sung Choi ),( Hong-weon Lee ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.10
Isoprene has the potential to replace some petroleum-based chemicals and can be produced through biological systems using renewable carbon sources. Ralstonia eutropha can produce value-added compounds, including intracellular polyhydroxyalkanoate (PHA) through fatty acid and lipid metabolism. In the present study, we engineered strains of R. eutropha H16 and examined the strains for isoprene production. We optimized codons of all the genes involved in isoprene synthesis by the mevalonate pathway and manipulated the promoter regions using pLac and pJ5 elements. Our results showed that isoprene productivity was higher using the J5 promoter (1.9 ± 0.24 μg/l) than when using the lac promoter (1.5 ± 0.2 μg/l). Additionally, the use of three J5 promoters was more efficient (3.8 ± 0.18 μg/l) for isoprene production than a one-promoter system, and could be scaled up to a 5-L batch-cultivation from a T-flask culture. Although the isoprene yield obtained in our study was insufficient to meet industrial demands, our study, for the first time, shows that R. eutropha can be modified for efficient isoprene production and lays the foundation for further optimization of the fermentation process.
( Sung Noh Hong ),( Young Il Min ),( Jeong Whan Kim ),( Sun Young Lee ),( Won Hyeok Choe ),( In Kyung Sung ),( So Young Kwon ),( Hyung Seok Park ),( Choon Jo Jin ),( Chang Hong Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Emerging evidence revealed that the metabolic syndrome (MeS) is associated with the risk of colorectal adenoma. In addition, the individual component of MeS may attribute the development of colorectal adenoma respectively. However, there was no previous study to evaluate whether the clustering of multiple components of MeS has a greater impact on risk of colorectal adenoma. Thus, we evaluate that relationship the colorectal adenoma and ``metabolic score``, the sum of the five metabolic syndrome components in age, sex, lifestyle and dietary factor adjusted model. Methods: Cross-sectional data from 126 cases (adenoma group) and 762 adenoma-free controls (control group) who underwent colonoscopies and completed lifestyle and dietary questionnaires at the Health. Promotion Center, Konkuk University Hospital, from July 2006 to June 2007, were used in this analysis. According to the modified ATP III criteria, metabolic syndrome was diagnosed. Multivariable logistic regression was used to estimate the association between ``metabolic score`` and prevalence of colorectal adenoma. Results: The prevalence for metabolic syndrome was 38% in the adenoma group and 24% in the control group. On the multiple logistic regression analyses, metabolic syndrome was found to be associated with increased risk of colorectal adenoma (odds ratio, 1.93; 95% confidence interval, 1.30-2.82). Also, age, sex, lifestyle and dietary factor adjusted odds ratios of colorectal adenoma for accumulation of component of metabolic syndrome of 0, 1, 2, 3, and 4-5 were 1.0 (referent), 2.25, 3.18, 3.64 and 9.28, respectively (95% confidence interval; 2.04, 42.20; p-trend<0.001). Conclusions: The risk of colorectal adenoma was increased as the components of the MeS were accumulated. The clustering of multiple components of MeS appears to have an additive effect on risk of colorectal adenoma.