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Ryu, Jong Hwa,You, Young Gyu,Kim, Sung Won,Hong, Jun Ho,Na, Jeong Hyeon,Jhang, Sung Ho Elsevier 2020 Current Applied Physics Vol.20 No.2
<P><B>Abstract</B></P> <P>The effect of Al<SUB>2</SUB>O<SUB>3</SUB> deposition on electrical properties and ambient stability of few-layer MoS<SUB>2</SUB> transistors is investigated. The deposition of Al<SUB>2</SUB>O<SUB>3</SUB> passivation layer by atomic layer deposition method resulted in the suppression of the hysteresis in the transfer curve and the enhancement of carrier mobility due to high-κ dielectric screening effect. In addition, the negative shift of threshold voltage (enhanced n-doping) and the metal-insulator transition at the carrier density n ~ <SUP> 10 13 </SUP> cm<SUP>−2</SUP> is reported. The Al<SUB>2</SUB>O<SUB>3</SUB> passivation layer helps electrical properties of MoS<SUB>2</SUB> transistor are preserved even after 11 months. Al<SUB>2</SUB>O<SUB>3</SUB> encapsulation provides a facile method to suppress extrinsic effect on the mobility of few-layer MoS<SUB>2</SUB> transistors and to ensure the ambient stability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Al<SUB>2</SUB>O<SUB>3</SUB> passivation enhances the mobility of few-layer MoS<SUB>2</SUB> by dielectric screening effect. </LI> <LI> Negative shift of threshold voltage (enhanced n-doping) with Al<SUB>2</SUB>O<SUB>3</SUB> passivation. </LI> <LI> Metal-insulator transition at the current density of ~10<SUP>13</SUP> cm<SUP>−2</SUP>, observed in trilayer MoS<SUB>2</SUB>. </LI> <LI> Al<SUB>2</SUB>O<SUB>3</SUB> passivation provides a facile method to ensure ambient stability. </LI> </UL> </P>
Sung Won Ryu,Hwa Min Kim,Hong J-S,홍우표,안정선,Kim J-J,J.-Y. Moon,박승환,Yang J-M,Yang J-Y 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.3
Inorganic (ZnO)$_{100-x}$(Nd$_2$O$_3$)$_x$ alloy films were prepared at room temperature by the rf-magnetron sputtering, and their optical properties were investigated as functions of the Nd$_2$O$_3$ contents in the films, the film's thickness, and the oxygen content introduced during deposition. These alloy films showed various absorption bands in their optical transmission spectra measured in the visible range. The absorption bands that absorbed light in specific narrow ranges of wavelength could be explained by intra-transitions between the ground-state manifold $^4$$\it{I}$$^{9/2}$ and a number of excited states within the 4$\it{f}$ shell of the Nd$^{3+}$ ions. The absorptions was also shown to strongly depend on the concentration of Nd$^{3+}$ ion in the film and on the film's thickness. We expect that alloy films with a strong absorption band near 582.5 nm should be effective for filtering orange light emitted from a Ne gas discharge, resulting in the primary color purity of the plasma display panel (PDP) being greatly improved. In particular, we suggest that (ZnO)$_{20}$(Nd$_2$O$_3$)$_{80}$ alloy films are the most suitable for color filters of PDPs.
( Sang Kyu Kim ),( Won Bok Kim ),( Young Uk Ryu ) 대한물리의학회 2014 대한물리의학회지 Vol.9 No.3
PURPOSE : This study intended to verify whether there was actual correlation between weight bearing asymmetry and a limitation in hip joint rotation range in patients with low back pain. METHODS : Thirty five low back pain patients voluntarily participated this study. For each participant, hip joint medial rotation symmetry rate and the weight-bearing symmetry rate were calculated. The correlation between the two variables was investigated. RESULTS : A decrease in the left hip joint medial rotation range of motion (ROM) was observed more often than a reduction in the right hip joint medial rotation ROM. However, similar number between right and left side was observed in ground reaction force more weighted. The coefficient between the passive hip joint medial rotation symmetry rate and the weight loading symmetry ratio was -0.19 (p < 0.05). CONCLUSION : The present study demonstrated a weak correlation between the hip joint medial rotation ROM and the weight distribution of both feet. Such result suggests that careful evaluation by separating each element is needed in treating patients with low back pain. Future research should take into account asymmetric alignment and abnormal movement in different joints of the body as well as asymmetry in the bilateral hip joint rotation and the unilateral weight supporting posture.
Ryu Yeon Hee,Moon Suk-Ho,Kim Ki Joo,Jun Young Joon,Oh Deuk-Young,Kim Sang‐Heon,Rhie Jong-Won 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.3
Background: Angiogenesis and vasculogenesis are essential processes for successful tissue regeneration in tissue engineering and regenerative medicine. The adipose-derived stromal vascular fraction (SVF) is not only a source of adipose stem cells (ASC) but also a suitable source of microvascular endothelial cells because it is a rich capillary network. So, we propose a new hypothesis for isolating adipose-derived human microvascular endothelial cells (HMVEC-A) from the SVF and developed a dual isolation system that isolates two cell types from one tissue. Method: To isolate HMVEC-A, we analyzed the supernatant discarded when ASC is isolated from the adipose-derived SVF. Based on this analysis, we assumed that the SVF adherent to the bottom of the culture plate was divided into two fractions: the stromal fraction as the ASC-rich fraction, and the vascular fraction (VF) as the endothelial cells-rich fraction floating in the culture supernatant. VF isolation was optimized and the efficiency was compared, and the endothelial cells characteristics of HMVEC-A were confirmed by flow cytometric analysis, immunocytochemistry (ICC), a DiI-acetylated low-density lipoprotein (DiI-Ac-LDL) uptake, and in vitro tube formation assay. Results: Consistent with the hypothesis, we found a large population of HMVEC-A in the VF and isolated these HMVEC-A by our isolation method. Additionally, this method had higher yields and shorter doubling times than other endothelial cells isolation methods and showed typical morphological and phenotypic characteristics of endothelial cells. Conclusion: Cells obtained by the method according to our hypothesis can be applied as a useful source for studies such as tissue-to-tissue networks, angiogenesis and tissue regeneration, patient-specific cell therapy, and organoid chips. Background: Angiogenesis and vasculogenesis are essential processes for successful tissue regeneration in tissue engineering and regenerative medicine. The adipose-derived stromal vascular fraction (SVF) is not only a source of adipose stem cells (ASC) but also a suitable source of microvascular endothelial cells because it is a rich capillary network. So, we propose a new hypothesis for isolating adipose-derived human microvascular endothelial cells (HMVEC-A) from the SVF and developed a dual isolation system that isolates two cell types from one tissue. Method: To isolate HMVEC-A, we analyzed the supernatant discarded when ASC is isolated from the adipose-derived SVF. Based on this analysis, we assumed that the SVF adherent to the bottom of the culture plate was divided into two fractions: the stromal fraction as the ASC-rich fraction, and the vascular fraction (VF) as the endothelial cells-rich fraction floating in the culture supernatant. VF isolation was optimized and the efficiency was compared, and the endothelial cells characteristics of HMVEC-A were confirmed by flow cytometric analysis, immunocytochemistry (ICC), a DiI-acetylated low-density lipoprotein (DiI-Ac-LDL) uptake, and in vitro tube formation assay. Results: Consistent with the hypothesis, we found a large population of HMVEC-A in the VF and isolated these HMVEC-A by our isolation method. Additionally, this method had higher yields and shorter doubling times than other endothelial cells isolation methods and showed typical morphological and phenotypic characteristics of endothelial cells. Conclusion: Cells obtained by the method according to our hypothesis can be applied as a useful source for studies such as tissue-to-tissue networks, angiogenesis and tissue regeneration, patient-specific cell therapy, and organoid chips.
Sang-Lyul Ryu,Yeong-wha Sawng,Seunglak Park,Jayoun Won 한국무역학회 2021 Journal of Korea trade Vol.25 No.7
Purpose – This paper’s purpose is to investigate how foreign ownership and innovation affect firm value. Design/methodology – Firm innovation is defined as operational efficiency, which is calculated by adopting data envelopment analysis (DEA). Additionally, R&D intensity is included as a measure of innovation in the analysis. We used firm-level data from manufacturing companies in Korea. The sample comprised 3,753 firm-year observations for every year in the period 2003–2017. Findings – We found that foreign ownership and innovation are positively related to firm value (Tobin’s Q). Foreign ownership moderates innovation’s contribution to firm value, implying that foreign ownership may enhance the value relevance of firm innovation. In addition, we found that firm innovation partially mediates the relationship between foreign ownership and firm value. Originality/value – This highlights the important role of foreign investors’ monitoring; wherein foreign investors enhance firm value by facilitating firm innovation. Our results suggest that foreign ownership can be crucial for innovation and may serve to address weak ownership structures.
Ryu, Chung Heon,Park, Sang-Hoon,Park, Soon A,Kim, Seong Muk,Lim, Jung Yeon,Jeong, Chang Hyun,Yoon, Wan-Soo,Oh, Won-il,Sung, Young Chul,Jeun, Sin-Soo Mary Ann Liebert 2011 Human gene therapy Vol.22 No.6
<P>Clinical trials of gene therapy using a viral delivery system for glioma have been limited. Recently, gene therapy using stem cells as the vehicles for delivery of therapeutic agents has emerged as a new treatment strategy for malignant brain tumors. In this study, we used human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) as delivery vehicles with glioma-targeting capabilities, and modified interleukin-12 (IL-12p40N220Q; IL-12M) as a novel therapeutic gene. We also engineered UCB-MSCs to secret IL-12M (UCB-MSC-IL12M) via tetrameric cell-permeable peptide (4HP4)-mediated adenoviral transduction. We confirmed the migratory capacity of UCB-MSC-IL12M toward GL26 mouse glioma cells by an in vitro migration assay and in vivo injection of UCB-MSC-IL12M into the ipsilateral hemisphere of implanted gliomas in C57BL/6 mice. In vivo efficacy experiments showed that intratumoral injection of UCB-MSC-IL12M significantly inhibited tumor growth and prolonged the survival of glioma-bearing mice compared with control mice. Antitumor effects were associated with increased local IL-12M levels, followed by interferon-γ secretion and T-cell infiltration in intracranial gliomas, as well as antiangiogenesis. Interestingly, tumor-free mice after UCB-MSC-IL12M treatment were resistant to ipsilateral and contralateral tumor rechallenge, which was closely associated with tumor-specific long-term T-cell immunity. Thus, our results provide the rationale for designing novel experimental protocols to induce long-term antitumor immunity against intracranial gliomas using UCB-MSCs as an effective delivery vehicle for therapeutic cytokines including IL-12M.</P>