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ML 기법에 기반을 둔 측정치 융합기법을 가진 다중표적 방위각 추적 알고리즘
류창수(Chang-Soo Ryu),박주태(Ju-Tae Park),최성운(Sung-Un Choi) 한국산업융합학회 2003 한국산업융합학회 논문집 Vol.6 No.3
Recently, Ryu et al. proposed a multiple target DOA tracking algorithm, which has good features that it has no data association problem and simple structure. But its performance is seriously degraded in the low signal-to-noise ratio. In this paper, a measurement fusion method is presented based on ML(Maximum Likelihood), and the new DOA tracking algorithm is proposed by incorporating the presented fusion method into Ryu's algorithm. The proposed algorithm has a better tracking performance than that of Ryu's algorithm, and it sustains the good features of Ryu's algorithm.
Abnormal high-Q modes of coupled stadium-shaped microcavities.
Ryu, Jung-Wan,Lee, Soo-Young,Kim, Inbo,Choi, Muhan,Hentschel, Martina,Kim, Sang Wook Optical Society of America 2014 Optics letters Vol.39 No.14
<P>It is well known that the strongly deformed microcavity with fully chaotic ray dynamics cannot support high-Q modes due to its fast chaotic diffusion to the critical line of refractive emission. Here, we investigate how the Q factor is modified when two chaotic cavities are coupled, and show that some modes, whose Q factor is about 10 times higher than that of the corresponding single cavity, can exist. These abnormal high-Q modes are the result of an optimal combination of coupling and cavity geometry. As an example, in the coupled stadium-shaped microcavities, the mode pattern extends over both cavities such that it follows a whispering-gallery-type mode at both ends, whereas a big coupling spot forms at the closest contact of the two microcavities. The pattern of such a 'rounded bow tie' mode allows the mode to have a high-Q factor. This mode pattern minimizes the leakage of light at both ends of the microcavities as the pattern at both ends is similar to the whispering gallery mode.</P>
Ryu, Chung Heon,Park, Sang-Hoon,Park, Soon A,Kim, Seong Muk,Lim, Jung Yeon,Jeong, Chang Hyun,Yoon, Wan-Soo,Oh, Won-il,Sung, Young Chul,Jeun, Sin-Soo Mary Ann Liebert 2011 Human gene therapy Vol.22 No.6
<P>Clinical trials of gene therapy using a viral delivery system for glioma have been limited. Recently, gene therapy using stem cells as the vehicles for delivery of therapeutic agents has emerged as a new treatment strategy for malignant brain tumors. In this study, we used human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) as delivery vehicles with glioma-targeting capabilities, and modified interleukin-12 (IL-12p40N220Q; IL-12M) as a novel therapeutic gene. We also engineered UCB-MSCs to secret IL-12M (UCB-MSC-IL12M) via tetrameric cell-permeable peptide (4HP4)-mediated adenoviral transduction. We confirmed the migratory capacity of UCB-MSC-IL12M toward GL26 mouse glioma cells by an in vitro migration assay and in vivo injection of UCB-MSC-IL12M into the ipsilateral hemisphere of implanted gliomas in C57BL/6 mice. In vivo efficacy experiments showed that intratumoral injection of UCB-MSC-IL12M significantly inhibited tumor growth and prolonged the survival of glioma-bearing mice compared with control mice. Antitumor effects were associated with increased local IL-12M levels, followed by interferon-γ secretion and T-cell infiltration in intracranial gliomas, as well as antiangiogenesis. Interestingly, tumor-free mice after UCB-MSC-IL12M treatment were resistant to ipsilateral and contralateral tumor rechallenge, which was closely associated with tumor-specific long-term T-cell immunity. Thus, our results provide the rationale for designing novel experimental protocols to induce long-term antitumor immunity against intracranial gliomas using UCB-MSCs as an effective delivery vehicle for therapeutic cytokines including IL-12M.</P>
Ryu, Ju Hee,Lee, Aeju,Chu, Jun‐,Uk,Koo, Heebeom,Ko, Chang‐,Yong,Kim, Han Sung,Yoon, Soo‐,Young,Kim, Byung‐,Soo,Choi, Kuiwon,Kwon, Ick Chan,Kim, Kwangmeyung,Youn, Inchan Wiley Subscription Services, Inc., A Wiley Company 2011 Vol.63 No.12
<P><B>Abstract</B></P><P><B>Objective</B></P><P>Early treatment based on an early diagnosis of rheumatoid arthritis (RA) could halt progression of the disease, but early diagnosis is often difficult. Matrix metalloproteinase 3 (MMP‐3) is thought to be particularly important in the pathogenesis of RA. The aim of this study was to investigate whether an MMP‐3–specific polymeric probe could be used for early diagnosis and for visualizing the progression of arthritis, using a near‐infrared fluorescence (NIRF) imaging system.</P><P><B>Methods</B></P><P>The MMP‐3–specific polymeric probe was developed by conjugating NIRF dye, MMP substrate peptide, and dark quencher to self‐assembled chitosan nanoparticles. One hour after intravenous administration of the probe, fluorescent images of mice with collagen‐induced arthritis at different stages of disease development were obtained. The correlation between the fluorescence recovered in in vivo imaging when using an MMP‐3–specific polymeric probe and up‐regulated MMP‐3 activity in the joint tissues was evaluated by Western blotting and immunohistochemical staining. Histologic analysis and micro–computed tomography (micro‐CT) were also used to assess arthritis progression.</P><P><B>Results</B></P><P>A significantly higher NIRF signal was recovered from arthritic joints compared with normal joints at 14 days after the first immunization, before any erythema or swelling could be observed with the naked eye or any erosion was detected by histologic analysis or micro‐CT. The results of immunohistochemical analysis and Western blotting confirmed that the fluorescence recovered in the in vivo imaging was related to up‐regulated MMP‐3 activity in the joint tissues.</P><P><B>Conclusion</B></P><P>An MMP‐3–specific polymeric probe provided clear early diagnosis of arthritis and visualization of arthritis progression using an NIRF imaging system. This approach could be used for early diagnosis and for monitoring drug and surgical therapies in individual cases.</P>
Kinetics and Mechanism of the Addition of Anilines to β-Nitrostilbenes in Acetonitrile
Sung, Dae-Dong,Kang, Sang-Soo,Lee, Jong-Pal,Jung, Dae-Il,Ryu, Zoon-Ha,Lee, Ik-Choon Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.10
Addition reactions of anilines (XC6H4NH2) to β-nitrostilbene (YC6H4CH=C(NO2)C6H4Y') have been investigated in acetonitrile at 30.0 oC. The magnitude of βX values (=0.11-0.34) indicates relatively earlier transition state for additions with anilines than with benzylamines. The signs of ρY and ρY' are positive with Δρ = ρY?ρY' = 0.04, demonstrating a TS imbalance with a negative charge development on the Cβ in the TS. The signs of cross-interaction constants ρXY (<0), ρXY' (<0) and ρYY' (>0) are consistent with bond forming and breaking processes. The relatively weak normal kinetic isotope effects involving deutarated nucleophiles, kH/kD>1, suggest an early, hydrogen-bonded, 4-member cyclic TS.
Ryu, Jae San,Lee, Sang Dae,Lee, Young Han,Lee, Seong Tae,Kim, Dong Kil,Cho, Soo Jeong,Park, Sang Ryeol,Bae, Dong Won,Park, Ki Hun,Yun, Han Dae 한국미생물 · 생명공학회 2000 Journal of microbiology and biotechnology Vol.10 No.4
A pathogenic fungus causing balloon flower root rot (Platvcodon grandiflorum) was isolated from naturally infected roots. The microbial characteristics of the isolated microorganism were similar to those of Rhizoctonia solani. About 500 bacterial species from field soils were screened for a biological agent against the above-mentioned putative pathogen, and several bacteria with the antifungal activity were isolated. Among them, the isolated JS2 was identified as Pseudomonas aeruginosa. This strain showed a broad spectrum of antifungal activity potentially. When the antifungal substance was purified from a broth culture of JS2, it was identified as 2,4-diacetylphloroglucinol (Ph1).
Sung Soo Kim,Hyun Kuk Kim,Hyung Wook Park,Myung Ho Jeong,임경섭,Hae Jin Kee,Yu Hee Ryu,Han Byul Kim,Joo-Young Na,Young-Jae Ki,Keun-Ho Park,Dong-Hyun Choi,Ki Hong Lee,Nam Sik Yoon,Jeong Gwan Cho 대한심장학회 2020 Korean Circulation Journal Vol.50 No.1
Background and Objectives: Antiarrhythmic effect of renal denervation (RDN) after acute myocardial infarction (AMI) remains unclear. The goal of this study was to evaluate the effect of RDN on ventricular arrhythmia (VA) after AMI in a porcine model. Methods: Twenty pigs were randomly divided into 2 groups based on RDN (RDN, n=10; Sham, n=10). After implanting a loop recorder, AMI was induced by occlusion of the middle left anterior descending coronary artery. Catheter-based RDN was performed for each renal artery immediately after creating AMI. Sham procedure used the same method, but a radiofrequency current was not delivered. Electrocardiography was monitored for 1 hour to observe VA. One week later, the animals were euthanized and the loop recorder data were analyzed. Results: Ventricular fibrillation event rate and the interval from AMI creation to first VA in acute phase were not different between the 2 groups. However, the incidence of premature ventricular complex (PVC) was lower in the RDN than in the Sham. Additionally, RDN inhibited prolongation of the corrected QT (QTc) interval after AMI. The frequency of non-sustained or sustained ventricular tachycardia, arrhythmic death was lower in the RDN group in the early period. Conclusions: RDN reduced the incidence of PVC, inhibited prolongation of the QTc interval, and reduced VA in the early period following an AMI. These results suggest that RDN might be a therapeutic option in patients with electrical instability after AMI.
Ryu, Seok-Woo,Kim, Jae Hyung,Kim, Mi Kyung,Lee, Youn-Jeong,Park, Jun-Soo,Park, Hyoung-Moo,Kim, Dong-Ho,Lee, Sang-Hoon,Lee, Eun-Ju BMJ 2013 International journal of gynecological cancer Vol.23 No.1
<B>Objective</B><P>The aim of this study was to assess the expression of DKK3 protein and its target, beta-catenin, in uterine cervical squamous cell carcinoma and to determine potential clinical correlations.</P><B>Materials and Methods</B><P>Six carcinoma in-situ (CIS) tissues and 88 invasive cervical cancer tissues were included in the study. Twenty-two normal cervical tissues and one gastric cancer tissue were used as controls. The expression of DKK3 and beta-catenin proteins was evaluated by immunohistochemical analysis. Clinical and pathological parameters were obtained from medical records. Survival data were estimated using Kaplan-Meier estimates and compared with a log-rank test. Multivariate analysis was performed using the Cox regression method.</P><B>Results</B><P>DKK3 was predominantly present in the cytoplasm. Beta-catenin was observed only on the cellular membrane of both normal and cancer cells in contrast to earlier reports, in which beta-catenin was localized to the cytoplasm and nucleus of cancer cells. The expressions of beta-catenin and DKK3 were not correlated. Three of 6 CIS (50%) and 57 of 88 invasive cancer specimens (64.8%) had lower DKK3 expression than normal controls. DKK3 expression was decreased in a stage-dependent manner (<I>P</I> = 0.021). The patients with low expression of DKK3 were older than those with high expression of DKK3 (<I>P</I> < 0.01). Moreover, the patients with low DKK3 expression had a significantly lower 5-year disease-free survival rate than those with high DKK3 expression (<I>P</I> = 0.026). A multivariate analysis showed that International Federation of Gynecology and Obstetrics clinical stage and parametrial involvement were independent prognostic factors.</P><B>Conclusion</B><P>Decreased DKK3 expression was associated with advanced International Federation of Gynecology and Obstetrics clinical stages and was predictive of lower disease-free survival in patients with cervical squamous cell carcinoma. DKK3 may be implicated in cervical carcinogenesis through a beta-catenin-independent mechanism.</P>