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Joung, Hyou-Arm,Shim, Won-Bo,Chung, Duck-Hwa,Ahn, Jun-Hyoung,Chung, Bong-Hyun,Choi, Ho-Suk,Ha, Sang-Do,Kim, Keun-Sung,Lee, Kyu-Ho,Kim, Cheol-Ho,Kim, Kwang-Yup,Kim, Min-Gon Korean Society for Biotechnology and Bioengineerin 2007 Biotechnology and Bioprocess Engineering Vol.12 No.2
In this study, a specific monoclonal antibody against Listeria monocytogenes was screened using an SPR biosensor. Monoclonal antibodies were bound to protein L, after which the L. monocytogenes cells were subjected to an affinity assay. Protein L was immobilized on a carboxymethyl extran (CM-Dex) surface via an amine coupling method, and utilized repeatedly by regeneration. The monoclonal antibody, 'A18', was selected and employed for the high-sensitivity detection of L. monocytogenes. Under optimized conditions, $10^3 cells/mL$ or 50 cells were detected by the SPR biosensor.
오막엽,도애옥,이지혜,심외정,이상옥,허목,장동수,나수정,김진범,류진경 韓國保健敎育學會 1997 보건교육건강증진학회지 Vol.14 No.1
In order to develop the programme for the improvement of dental health among primary school children, epidemiological survey to examine dental caries status was conducted among primary school children in Changwon, Korea. We sampled 2 primary schools and surveyed children from first to sixth grade aged 6-11 years. All samples were 3,206 consisted of 1,715 males and 1,491 females. We assessed caries prevalence on permanent teeth. 1. Children with caries experience on permanent teeth were 15.1% at 1st grade, 48.2% at 2nd grade, 73.8% at 3rd grade, 75.65 at 4th grade, 76.8% at 5th grade, 77.4% at 6th grade. 2. Decayed, Missing and Filled teeth were 0.31 at 1st grade, 1.16 at 2nd grade, 2.12 at 3rd grade, 2.38 at 4th grade, 2.50 at 5th grade, 2.69 at 6th grade. 3. Decayed teeth among Decayed, Missing and Filled teeth were totally 63.4% Filled teeth among Decayed, Missing and Filled teeth were totally 36.6%. 4. Community dental health programmes including water fluoridation, fluoride mouth rinsing, use of fluoride-containing toothpastes and fissure sealants should be developed to prevent dental caries among school children. 5. School incremental dental care programme should be also developed to prevent and treat children's dental caries by use of dentists and oral hygienists.
Kang, Sanghee,Na, Younghyun,Joung, Sung Yup,Lee, Sun Il,Oh, Sang Cheul,Min, Byung Wook Williams & Wilkins Co 2018 Medicine Vol.97 No.9
<P><B>Abstract</B></P><P>The colorectal cancer (CRC) patients with microsatellite instability (MSI) have distinct clinicopathological characteristics consisting of factors predicting positive and negative outcomes, such as a high lymph node harvest and poor differentiation. In this study, we measured the value of MSI as a prognostic factor after controlling for these discrepant factors. A total of 603 patients who underwent curative surgery for stages I to III colorectal cancer were enrolled. The patients were divided into microsatellite instability high (MSI-H) and microsatellite stable/microsatellite instability low (MSS/MSI-L) groups. Propensity score matching was used to match clinicopathological factors between the 2 groups. MSI-H patients had a high lymph node harvest (median: 31.0 vs 23.0, <I>P < </I>.001), earlier-stage tumors (<I>P < </I>.001), advanced T stage (89.3% vs 74.0%, <I>P = </I>.018), and poor differentiation (19.6% vs 2.0%, <I>P < </I>.001). Survival analysis showed better survival in the MSI-H group, but the difference was not statistically significant (<I>P = </I>.126). Propensity score matching was performed for significant prognostic factors identified by Cox hazard regression. After the matching, the survival difference by MSI status was estimated to be larger than before, and reached statistical significance (<I>P = </I>.045). In conclusion, after controlling for pathological characteristics, MSI-H could be a potent prognostic factor regarding patient survival.</P>
갑상선 결절 환자에서 혈청 갑상선자극호르몬 수치와 고분화 갑상선암과의 연관성에 관한 분석
정성엽,김훈엽,류우상,우상욱,손길수,이재복,배정원,Sung Yup Joung,Hoon Yub Kim,Woo Sang Ryu,Sang Uk Woo,Gil Soo Son,Jae Bok Lee and Jeoung Won Bae 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.4
Purpose: This study investigated the effects of serum thyroid-stimulating hormone (TSH) levels in predicting malignancy-associated differentiated thyroid cancer (DTC) and benign thyroid nodules. Methods: Between January 2005 and December 2007, 346 patients underwent thyroid surgery at one hospital. Their records were retrospectively reviewed. Results: Sixty-nine percent (237 of 346) of the patients had DTC. The mean preoperative TSH level was higher than in the malignant group (5 uIU/ml vs 0.4 uIU/ml). The rate of malignancy was the 71% in patients with TSH levels >5 uIU/ml. The TSH level of DTC with metastasis of the lymph node was higher than that with non-metastasis (3.08 uIU/ml vs 2.09 uIU/ml, P<0.01) Conclusion: The likelihood of DTC increases with higher serum TSH concentration. Serum TSH level might be useful in predicting malignant nodular thyroid lesion. (Korean J Endocrine Surg 2010;10:220-223)