개에서 관찰된 모기질세포종의 증례보고

조성환,손화영,김혜성,최종윤,류시윤,박배근,윤원기,홍성혁,김덕환 충남대학교 수의과대학 동물의과학연구소 2002 動物醫科學硏究誌 Vol.10 No.-

Pilomatricoma was histopathologically diagnosed in a 2.5-year-old male Alaskan malamute. The patient was referred to Chungnam National University, Veterinary Medical Teaching Hospital with solitary, firm and well-circumscribed mass at shoulder. Grossly, the mass was dome shaped to tumor like and 10 x 8 x 5㎝ in size. Some lesions had gritty or bony consistency and was chalky when sectioned Histopathologic feature included mumerous clusters of tightly arranged, basaloid cells with evenly distributed chromatin and ghost cells were characterized by a central unstained zone. The ghost cells often become calcified and osseous metaplasia was also present.

CBT를 이용한 안전한 멀티캐스트 그룹 관리

윤성현,장주만,조원환 高麗大學校附設 컴퓨터科學技術硏究所 1999 JOURNAL OF COMPUTER SCIENCE & ENGINEERING TECHNOLO Vol.2 No.-

보다 높은 대역폭에서 안전한 멀티캐스트 통신을 하고자 욕구는 기업, 정부, 그리고 인터넷을 사용하는 모든 단체에서의 고조되고 있고 또한 주요 관심사이다. 멀티캐스트 환경에서 보안성을 제공하기 위해 최근까지 진행되어 오고 있는 연구는 주로 그룹 키 관리 기법에 관한 것들이다. 본 논문에서는 화장성이 우수한 CBT 멀티캐스트 라우팅 프로토콜을 기반으로 안전한 인터넷 멀티캐스트를 위한 CBT기반 그룹 관리 시스템을 제안한다. 본 논문에서 제안하는 기법은 핵심라우터가 키 생성, 키 재구성, 그룹 가입, 탈퇴 등 그룹 관리 뿐 아니라 여러 가지 보안사항을 고려한 기능도 제공해 준다. The need for high bandwidth, very dynamic secure internet multicast communications is increasingly evident in a wide variety of commercial, government, and Internet communities. One of the most recently researches is mainly about the group key management schemes. In this paper, We'll propose a CBT-based group management system with scalable CBT multicast routing protocol. The benefits of this proposed technique are that it offers not only key generation, rekey, group join and leaving but also many functions lated security of multicast group.

모잘록병균(Pythium ultimum)에 대한 N-Phenylbenzenesulfonamide 유도체의 살균활성에 미치는 구조적 특성

조윤기,장기운,성낙도 충남대학교 농업과학연구소 2008 농업과학연구 Vol.35 No.1

The structural characteristics that influence on the fungicidal activities of N-phenylbenzenesulfonamide (1∼24) and N-phenyltheinylsulfonamide (25∼30) derivatives against Dampping-off (Pythium ultimum) were discussed quantitatively using the models of molecular holographic quantitative structure-activity relationships (HQSAR). From the based on these findings, the statistical results of the optimized HQSAR F-3 model showed better predictablity (r² cv. or q²=0.581) and correlation coefficient (r²_(ncv).=0.963). And, from the analytical results of the atomic contribution maps on the fungicidal activities, the most active compound is R₁= 2-fluoro-4-chloro substituent (4) and the most inactive one is R₁=4-methoxy substituent (20). It was found that the 2-fluoro-4-chlorophenyl group as a R₁-group was an important structure and a characteristic factor not only for herbicidal activity but also for fungicidal activity.

孔子의 敎育思想

趙相衍 淸州敎育大學校 1973 論文集 Vol.9 No.1

Carotenoids 식이와 알코올이 혈액학적 성분과 간조직에 미치는 영향에 관한 연구

조만희,김연선,이상한,우기민,장예진,김창세 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Alcohol is well known agent which can damage the human tissues such as liver via stimulating lipid peroxidation and storage, denaturation of macromolecules, and inhibiting protein metabolism. On the other hand, carotenoids in addition to vitamins A, C, E and lipoic acid, play important roles in protecting these oxidative damages as well as preventing the production of free radicals. This study was carried out to elucidate the precise effects of alcohol administration into rats on the antioxidative functions of dietary carotenoids and isolated β-carotene, and to find out any parameters to uncover more detailed biochemical mechanisms of these agents. For these purposes, two different approaches were performed: 1) examination of the changes in hematological parameters (e.g., total proteins, A/G ratio, ALT/AST et. al) and statistical correlations among inter- and intragroups, 2) examination of the histopathological changes by an electron microscope. The results were analyzed and summarized as following; (1) Carrot diet for one week caused a slight increase in albumin. A/G ratio and AST levels, and a slight decrease in ALT, ALP, BUN and uric acid levels. Two-week alcohol administration following carrot diet increased total proteins, albumin A/G ratio and BUN levels. However, both groups were shown to have little significant changes in cholesterol concentrations. (2) Cheese diet for one week caused a significant increase in total proteins, albumin, AST, ALP, uric acid and total cholesterol levels, and a significant decrease in A/G ratio and glucose concentrations. However, two-week β-carotene diet following cheese intake increased total proteins albumin, A/G ratio, BUN and total cholesterol levels, whereas AST, ALT, ALP and uric acid levels were decreased. (3) Alcohol administration for one week caused an increase in AST activities and a decrease in total proteins, albumin, ALT, ALP and BUN levels. A successive β-carotene diet following alcohol administration increased total proteins, albumin, ALT, ALP and BUN levels, whereas decreased AST and uric acid levels. However, there were not significant changes in A/G ratio, glucose and total cholesterol levels in both groups. (4) β-carotene diet for one week caused a slight increase in albumin, glucose, AST and uric acid levels, and a slight decrease in ALP and BUN levels. Two-weeks alcohol administration following β-carotene diet increased albumin, glucose, BUN and total cholesterol levels, whereas decreased AST, ALT, ALP and uric acid levels. (5) Although the pathological investigation on the liver did not reveal significant changes, cheese diet group (CH-BC/1-CH) was shown to have some lipid deposits. Some results were unexpected and different from typical hematological changes shown by other researchers. Nonetheless, these results strongly suggest that the liver damage or hepatism caused by alcohol intake affects many kinds of biochemical metabolisms, which results in significant changes in many hematological parameters. In addition, dietary carotenoid and isolated β-carotene were shown to have protective roles against the biochemical changes by alcohol intake.

원인 미상의 설사와 복통으로 발현한 AL형 유전분증 1 예

조종태,윤성철 단국대학교 1998 論文集 Vol.32 No.-

Primary systemic amyloidosis (AL amyloidosis) is an uncommon disease characterized by the accumulation in vital organs of a fibrillar protein consisting of monoclonal immunoglobulin light chains. It is a plasma cell dyscrasia usually accompanied by a bone marrow plasmacytosis and an M component in the serum or urine. The presenting features of AL amyloidosis are protean and frequently nonspecific, but the diagnosis is rarely made until symptoms or signs referable to a particular organ appear. The amyloid deposits cause cardiac or renal dysfunction and, ultimately, death. We report a case of AL amyloidosis, presented with unexplained diarrhea and abdominal pain for eight months, documented by a renal biopsy, and review the previous literatures

엔로플록사신 액제의 닭유래 병원세균에 대한 시험관내 항균효과 시험

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study the antimicrobial spectrum and sensitivity of a liquid formulation of enrofloxacin against the major six pathogenic bacteria isolated from the diseased poultry in Korea were evaluated in comparison with ciprfloxacin (CFX), gentamicin (GM) and penicillin (PC). A liquid form of enrofloxacin, a test material and ciprofloxacin showed at least 83% antibacterial activity against all of six test pathogenic microorganisms at the fixed concentration of 10 ㎍/㎖. Gentamicin and penicillin revealed much lower antibacterial activity at the same condition. We evaluated the liquid form of enrofloxacin as having widespread antibacterial spectrum against poultry infections. The liquid form of enrofloxacin showed potent antibacterial activity, with the MIC range being 0.12∼2 ㎍/㎖ against Gram positives, 0.06∼2 ㎍/㎖ against Gram negatives and 0.5∼2 ㎍/㎖ against Mycoplasma spp. These values were equivalent to or somewhat higher than those of ciprofloxacin, but much lower than those of gentamicn and penicillin. This new liquid form of enrofloxacin would find its way in application of mixing with drinking water for the prevention and treatment of diverse infections in chickens.

新羅 長板 打捺紋樣 평기와의 慶州 製作與否에 대하여

조성윤 이화사학연구소 2003 梨花史學硏究 Vol.0 No.30

In thesis, I would know which roof tiles with large-sized paddle-beat pattern of Silla period were produced in Gyeongju area. Up until today, On the basis of the excavated roof tiles in Gyeongju area, Those were not produced. And yet, Roof tiles with large-sized paddle-beat pattern of Goguryo period(高句麗時代) Sites and Backje(百濟時代) were excavated : Horogoru Castle(瓠蘆古壘), the Mireucksa Temple(彌勒寺). Also, Roof tiles with large-sized paddle-beat pattern of Unified Silla period(統一新羅時代) were manufactured in the province : Busosan Castle(扶蘇山城), Huengduck Temple(興德寺), while Roof tiles with large-sized paddle-beat pattern were not likely to produce those in the capital unifid Silla of Gyeongju area. The reason why roof tiles with large-sized paddle-beat pattern of Silla period was not produced in Gyeongju area seem to be caused manufacturing technique. And The reason why roof tiles with large-sized paddle-beat pattern of Unified Silla period was not produced in Gyeongju area could be call in the three questions. - Why is it that, while roof tiles manufacturing technic in Backje period has development workman of Silla was not to take in Backje of manufacturing technique? And, Why ever did roof tiles with medium-sized paddle-beat pattern of new manufacturing technic produce. - Roof tiles with large-sized paddle-beat pattern of Unified Silla period were not produced in Gyeongju area whether that is caused by manufacturing technique which is inferior to the roof tiles of manufacturing technique in the province. - We must make clear whoever is man who manufacture roof tiles with large-sized paddle-beat pattern, whether those are related to spread out zen Buddhim(禪宗). Henceforth a few korean archaeologists have to very interest roof tiles with large-sized paddle-beat pattern of Silla period in the Sites of the bulidings in Gyeongju area. And I expect to have been report roof tiles with large-sized paddle-beat pattern of Backje Kingdom in the Sites of the Backie bulidings.

배추좀나방(Plutella Xylostella Linnaeus)에 대한 새로운 살충활성 분자의 설계

조윤기,최우영,성낙도 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2

The new insecticidal active molecules from the based on the holographic quantitative structure-activity relationships (HQSAR) between a series of 1-(R₁)-2-(n-octyl)-3-(R₂), 3-(R₃)-pseudothiourea derivatives and their insecticidal activities against Diamond-back moth (Plutella Xylostella Linnaeus) were designed and discussed quantitatively. The most active molecule from the based graphical analyses of atomic contribution maps with the optimized HQSAR C-1 model (q²=0.764 & r²_(ncv)=0.942) was 1-(n-butyl)-2-(t-butyl)-3,3-diisopropylpseudothiourea (P1: pI_(50)=5.30, IC_(50)=1.397 ppm). Therefore, it is suggested that the new designed molecule would increased the activity as much as 23.5 times as compared to X=n-octyl substituent 17(pI_(50)=4.00, IC_(50)=32.86 ppm) which was the highest active molecule in training set compounds.

활성화 항원 CD30의 발현과 그 기능

조경신,허영문,남상윤 전주대학교 1999 論文集 Vol.24 No.2

CD30 is a member of the tumour necrosis factor receptor(TNFR) superfamily, and was originally recognized on Reed-Sternberg cells of Hodgkin's disease and, subsequently, on neoplastic cells of non-Hodgkin's disease and normal activated T, B, NK cells and macrophages. Several studies on CD30 expression of malignant cells suggest that CD30 may define relevant subgroups within the main tumor or lymphoma categories. Despite many controversial reports, it is noteworthy that CD30 is expressed solely on Th2 cells but not on Th1 cells after complete differentiation, because, so far, any specific markers of Thl or Th2 cells have not been demonstrated. Expression and its maintenance of CD30 is also dependent upon IL 4 which is a pivotal cytokine for Th2 differentiation and downregulated by FNv, a Thl type cytokine. These observations implicate that CD30 may regulate Th2 cell differentiation or proliferation. At the clonal level, CD30 was revealed to promote Th2 differentiation. Various functions of CD30 from in vitro studies have been described: induction of cell proliferation, apoptosis and cytokine production, inhibition of cell cytotoxicity, enhancement of B cell growth and Ig secretion, induction of NF-KB activation and induction of HIV expression in chronically infected T cells. Although the function of CD30 in vivo is largely unknown, several exciting findings are emerging from recent studies. Mice deficient in CD30 showed a mild impairment in thymic negative selection. Recently, it has been suggested that CD30 protects the body from autoimmunity by limiting the proliferative potential of autoreactive cytotoxic T cells. Taken together, CD30 studies may provide important knowledge for elucidation of the immunopathogenesis of and development of therapeutic regimen of AIDS, autoimmunity and other Th2-related diseases.