새로운 Ca^2+ 길항제의 혈압강하효과

함원훈,임태균,정윤성,정윤호,양재권,최원철 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1

Diltiazem and nifedipine, have been used throughout the world as an effective antianginal and antihypertensive agent. In order to increase the activity of these drugs, we synthesized the diltiazem-nifedipine coupling compounds. These compounds^(1-8) were tested for antihypertensive effect. Unfortunately, these compounds didn't show any promising activities.

NOx 제거를 위한 SNCR공정에서 환원제 분사조건의 전산모사

咸盛源 慶一大學校 1999 論文集 Vol.16 No.3

The commercial simulator based on the computational fluid dynamics was applied to predict the effect of the injection conditions such as injection location and velocity of reducing agent on NOx removal efficiency in SNCR process. The mixing and distribution of reducing agent was largely dependent upon the velocity field and temperature gradient of flue gas. The increase of mixing intensity between the flue gas and reducing agent was the most important factor to increase NOx removal efficiency. The computational fluid dynamics combined with chemical reactions was confirmed to be an economic and time-saving tool for the design of SNCR process.

새로운 연노출의 효과지표로서의 혈장 δ-aminolevulinic acid 측정의 유용성

이금원,황보영,김용배,리갑수,이성수,장봉기,함정오,안규동,이병국 순천향대학교 산업의학연구소 2001 순천향산업의학 Vol.7 No.1

To evaluate the usefulness of the measurement of plasma δ - aminolevulinic acid (ALAP) as a new effect indicator of lead exposure, the association of ALAP with blood lead, DMSA chelatable lead and bone lead with a special emphasis of genetic interaction of ALAD polymorphism was studied with 419 lead exposed workers and 85 non-lead exposed workers. Lead workers were recruited from storage battery industries, secondary smelting industries and other lead using industries and non-lead workers selected from electronic refrigerator manufacturing industry. Blood lead, DMSA chelatable lead and bone lead were chosen for parameters of lead exposure. Plasma and urinary ALA were selected for the effect parameter of lead intoxication. Information for age, smoking, drinking habit and body mass index were also obtained. Job duration for lead workers was also collected. The overall prevalence of the variant allele, ALAD type 1-2 or 2-2(ALAD2) in lead exposed workers was 10.0% (42 out of 419 lead workers) which was not differed from control workers (9.4% : 8 out of 85). The means blood lead and DMSA chelatable lead of lead workers with ALAD 1(ALAD type 1-1) were lower than those of lead workers with ALAD2, but the differences were not statistically significant. On the other hand, the mean of tibia lead of lead workers with ALADI was higher than that of lead workers with ALAD2, but the difference was not statistically significant. DMSA chelatable lead showed highest correlation with log transformed plasma ALA(LALAP)(r=0.682) and blood lead and tibia lead had r=0.650, r=0,402 correlation coefficient with LALAP respectively On the other hand. log transformed urinary ALA(LALAU) had lower correlation coefficient with all three parameters of lead exposure than LALAP. The equation of robustic simple linear regression of blood lead on LALAP was LALAP=2.0439+0.0165PbB in ALADI lead workers and LALAP=2.031+0.0121PbB in ALAD2 lead workers. ALAD genotype in the multiple regression analysis of blood lead with LALAP after adjusting for possible confounders(sex, ago, BMI, smoking and drinking status and job duration) showed significant main effect on LALAP resulting lower LALAP in ALAD2 lead workers than ALADI lead workers. On the other hand, effect modification of ALAD genotype was observed in the multiple regression analysis of tibia lead with LALAP after adjusting for possible confounders, but there was no significant effect of ALAD genotype in the multiple regression analysis of DMSA chelatable lead with LALAP after covariate adjustment. With above results, plasma ALA was found to be a useful effect parameter of lead exposure compared with urinary ALA. It was also observed that ALAD polymorphism made significant effect on the association of blood and tibia lead with ALAP. Thc lower plasma ALA in ALAD2 lead workers suggested supportive effect of ALAD2 in lead exposure.

원발성 위 소세포암 1례

윤상애,전혜정,함희원,박형석 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-

Small cell carcinoma originates from APUD cell of any part of the body. Usually the cases are discovered in the lung, and have poor prognosis. Primary small cell carcinoma of the stomach has been recognized recently, and only three cases have been reported in the Korea. This tumor is morphologically analogous to small cell carcinoma of the lung, and characterized by very aggressive clinical course. We report a case of primary small cell carcinoma of the stomach which had hepatic metastasis. The lesion of the stomach, located in the upper body and cardia, is ulcerated with irregular margin and dirty surface covered with exudates.

운동 유발성 횡문근 융해를 동반한 요로결석 2례

허진,최원혁,조진혁,함영희,홍정범,정성규,김현,허동 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Two men were admitted to hospital with flank pain, hematuria, which was diagnosised as ureteral stone. Elevation of aspartate aminotransferase (AST) without typical pattern of toxic hepatitis was observed. Careful history taking, several laboratory tests, abdominal and pelvis computered tomography was done. Findings from theses examinations supported the clinical diagnosis of ureteral stone complicated of exercised induced rabdomyolysis. Early recognization of rhabdomyolysis in clinical setting is important, because clinical manifestations have ranged from asymtomatic elevation of creatine kinase to acute renal failure which is a life threating medical emergency. Authors report two cases of exercised induced rhabdomyolysis initially admittied as ureteral stone managed with hydration

Melandrin의 방향족 유도체 합성에 관한 연구

임중기,이강노,함원훈,이상인 성균관대학교 약학연구소 1992 成均藥硏論文集 Vol.4 No.1

Melandrin, as a possible phytoalexin, which is expected to have the various pharmacological activities; antibacterial, antifungal and antiviral activity, was isolated in 1987 by Woo from Melandrin firmum (Caryophyllaceae). The synthesis of melandrin derivatives has been accomplished by the reaction of 5-hydroxy anthranilic acid ethyl ester with acid chlorides and then by hydrolysis of ethyl ester.

평면형 Bi-Sb 다중접합 열전변환기의 특성

이현철,유호종,김진섭,함성호,신장규,이종현,이정희,권성원,박세일 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

A planar Bi-Sb multijunction thermal converter for the precise measurements of ac voltage and current has been fabricated and its characteristics was discussed. In order to convert ac power into heat, a bifilar thin film Pt-heater, which could cancel its Thomson and Peltier effects, was prepared on the Si_(3)N_(4)/SiO_(2)/Si_(3)N_(4) diaphragm for the thermal isolation between heater and silicon substrate. To convert the temperature or the heat generated by the heater into dc voltage and current, hot and cold junctions of the Bi-Sb thermopile, which has a large difference in Seebeck coefficients, were formed on the dielectric diaphragm and the silicon substrate, respectively. The respective thermal sensitivity of the thermal converter with a bifilar heater was about 10.1 mV/mW and 14.8 mV/mW in the air and vacuum, which is about eight times higher than that of commercial 3-dimensional thermal converter. In the case of ac 2 V-input voltage, the ac-dc voltage transfer difference was about ±2.0 ppm, and in the case of ac 10 mA-input current, the ac-dc current transfer difference was about ± 0.6 ppm, in the frequency range from 10 Hz to 10 kHz.

Activity and Durability of Iron - exchanged Mordenite - type Zeolite Catalyst for the Reduction of NO by NH3

(Sung Won Ham),(In Sik Nam),(Young Gul Kim) 한국화학공학회 2000 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.38 No.3

NO removal activity and the durability of iron-exchanged mordenite type zeolite catalyst (FeHM) have been examined in a continuous fixed bed flow reactor. The catalytic activity for NO reduction by NH₃, in the presence of oxygen was much higher than that in the absence of oxygen, and it was fully reversible with respect to the presence of oxygen in the feed gas stream. The oxidation ability of SCR catalysts including FeHM was critical for both reactions of NH₃, and SO₂oxidation, thus for the NO removal activity and its sulfur tolerance. The maximum conversion of NO for FeHM catalyst with respect to the reaction temperature shifted to the higher temperature due to its mild oxidation ability. The deactivation behaviors such as the changes of the physicochemical properties of the catalyst and the loss of NO removal activity induced by SO₂could not be distinguished, regardless of the metals exchanged in zeolite. However, the amount of deactivating agents deposited on the catalyst surface depended on the species of metals exchanged on the mordenite type zeolite, which was mainly attributed to the oxidation ability of metals for SO₂conversion to SO₃.

Research Papers : Activity and Durability of Iron-exchanged Mordenite-type Zeolite Catalyst for the Reduction of NO by NH3

( Sung Won Ham ),( In Sik Nam ),( Young Gul Kim ) 한국화학공학회 2000 Korean Journal of Chemical Engineering Vol.17 No.3

Robotic Prostatectomy in Patient with an Abdominoperineal Resection

Ham, Won Sik,Kim, Sang Woon,Kim, Won Tae,Park, Sung Yul,Choi, Young Deuk Mary Ann Liebert 2009 Journal of laparoendoscopic & advanced surgical te Vol.19 No.3

<P>Robotic prostatectomy (RP) has been reported to be technically challenging in patients with a history of prior complex lower abdominal or pelvic surgery, morbid obesity, large prostate, prior pelvic irradiation, neoadjuvant hormonal therapy, or prior prostate surgery. In this paper, we report an experience of RP in a prostate cancer patient with abdominoperineal resection, adjuvant chemotherapy, and pelvic irradiation for rectal cancer.</P>