제2형 당뇨병 남성 환자에서 유리 테스토스테론과 성호르몬 결합 글로블린 농도

남기덕,김영설,박철영,오승준,김덕윤,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:인슐린저항성은 제2형 당뇨병과 심혈관질환의 주요한 위험 인자로 성호르몬과 상호 관계가 있다고 알려져 있다. 그러나 여성과는 달리 남성에서는 연령과 인슐린저항성에 따른 유리 테스토스테론과 성호르몬 결합 글로블린 농도의 변화에 대한 연구가 부족한 실정이다. 그러므로, 본 저자등은 제2형 당뇨병 남성 환자에서 정산인과 비교해서 유리 테스토스테론과 성호르몬 결합 글로블린 농도를 측정하고 연령에 따른 변화 정도를 알아보고자 하였다. 방법:대상 환자 모두에서 연령과 체질량지수, 총 콜레스테롤, 중성지방, 공복혈당과 인슐린 농도를 측정하였다. 혈중 유리 테스토스테론 농도는 방사면역측정법(radioimmunoassay)을 이용해서 측정하였고, 혈중 성호르몬 결합글로불린은 면역방사계측측정법(immunoradiometric assay)을 이용해서 측정하였다(Diagnostic System Laoratories, Wbster, TX, USA). 결과:1)제2형 당뇨병 남성 환자에서 정상 대조군 남성에 비해 성호르몬 결합글로불린은 104.1±35.0 vs 25.7±3.5 mole×10??로 의미 있게 높았으나(p<0.001), 유리 테스토스테론은 13.7±9.5 vs 13.6±6.5 ng/dL로 차이가 없었다. 2)연령과 성호르몬 결합 글로블린 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.40로 중등고의 양의 상관 관계를 보였고(p<0.001), 정상 대조군 남성에서 0.11로 유의한 상관 관계를 보이지 않았다. 연령과 유리 테스토스테론 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.08, 정상 대조군 남성에서-0.17로 모두에서 유의한 상관 관계를 보이지 않았다. 3)연령과 체질량지수를 보정한 후에 제2형 당뇨병 남성 환자와 정상 대조군 남성에서 혈중 인슐린 농도, 유리 테스토스테론과 성호르몬 결합 글로블린 사이에는 상관 관계가 없었다. 결론:제2형 당뇨병 남성 환자에서 정상 남성에 비해 성호르몬 결합 글로블린 농도가 증가되어 있었으며, 유리 테스토스테론은 차이가 없었다. 연령이 증가함에 따라 성호르몬 결합 글로블린이 제2형 당뇨병 남성 환자에서 정상 남성에 비해 증가 폭이 의미있게 컸으며, 유리 테스토스테론은 변화가 없었다. Background: Insulin resistance is a risk factor for cardiovascular disease and type 2 diabetes mellitus. There are many previous studies indicating that insulin lowers serum sex hormone-binding globulin levels, and there is inverse correlation between insulin resistance and serum sex hormone-binding globulin levels in women. However, in men, a limited number of studies are available to explain the effect of sex hormone on age and insulin. Therefore, the present study was undertaken to investigate the relationship among free testosterone, hormone-binding globulin and age in type 2 diabetic men and control subjects. Method: Age, body mass index, total cholesterol, triglyceride, fasting blood sugar, and insulin concentrations were examined on 89 type 2 diabetic men and 47 control subjects. The free testosterone level was measured by commercially available double-antibody system (Radioimmunoassay). The sex hormone-binding globulin level was also measured by commercially available double-antibody system(Immunoradiometric assay). Results: 1) Sex hormone-binding globulin level was significantly increased in patients with type 2 diabetes. However, there was no significantly difference in free testosterone level between the two groups. 2) Sex hormone-binding globulin was positively correlated with age (r=0.4, p <0.001) in patients with type 2 diabetes. Sex hormone-binding globulin and free testosterone were not correlated with age in control sujects. 3) Free testosterone and sex hormone-binding globulin concentrations were not significantly related to serum insulin concentration after adjusting for age and body mass index. Conclusions: We observed increased sex hormone-binding globulin concentration in diabetes man, and was a positively related to age. Further studies are needed to understand the relationships between age, insulin resistance, testosterone, and sex hormone-binding globulin concentrations(J Kor Diabetes Asso 24:699~707,2000).

學術硏究支援財團의 事業開發戰略에 관한 硏究

崔志雲,鄭基成 강릉대학교 영동산업문제연구소 1990 産經論叢 Vol.12 No.-

통합학교의 장애인 편의시설 실태와 개선방안에 관한 연구 : 수도권내 초등학교를 중심으로

변성헌,이규일,김상운,성기창,박광재,강병근 한국의료복지시설학회 2006 의료·복지 건축 Vol.12 No.1

This study was intended to present the proper operational scheme and present the criterion for establishment of proper convenient facilities and its planning method and the proper method of laying all sorts of teaching aids out. For this purpose, it attempted to investigate the type of crippled disorder and the behavioral characteristics of schoolchildren with crippled disorder with a focus on the descriptive study on disabled schoolchildren receiving complete integrated education. And it sought to analyze the present situation of complete integrated education and the case of integrated education and dissect the realities of its operation and the realities of the establishment of convenient facilities for disabled schoolchildren with a focus on the survey research.

Ethyl Cellulose를 이용한 요소비료의 방출에 관한 연구

한성철,이기영,김동운,송원현 全南大學校 觸媒硏究所 2002 觸媒硏究 論文集 Vol.23 No.-

Release study of urea fertilizer was performed using ethyl cellulose and rosin gum. Various effect on release kinetic was examind such as concentration of ethyl cellulose, types of emulsifier, and ethyl cellulose : rosin. Sustained release effect was optimal when 15%(w/v) ethyl cellulose, span 85, ethyl cellulose : rosin gum = 5 : 2 were used.

유량 센서를 위한 Pt/PtOx 박막제작과 그 특성

김호운,김정환,박성근,배승춘,김기완 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

The Pt/PtOx thin film for flow sensor was fabricated using two step RF magnetron sputtering method. At first, a PtOx film was deposited on the SiO2 or Alumina plate in O2 ambient then a Pt film was deposited on the PtOx film in Ar ambient. According to the AES, the Oxygen concentration in PtOx was about 20%. PtOx film was buffer layer for good Pt adhesion. Incorporated oxygen was completely removed after an annealing at 700℃ or higher. The PtOx film was dull brown after annealing the film was silvery. After annealing the resistivity of film was approached the value of Pt film.

Polyphosphate가 Porphyromonas endodontalis의 성장에 미치는 영향에 관한 연구

최성백,최호영,민병순,박상진,이진용,최기운 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.1

Polyphosphate has been used to prevent decomposition of foods and has been shown to have inhibitory effect on the growth of gram positive bacteria. The purpose of this study was to evaluate the effect of polyphosphate on the growth of Porphyromonas endodontalis, a gram negative endodontopathic bacterium. Porphyromonas endodontalis ATCC 35406 was grown in the presence of polyphosphates with different chain lengths. Inhibitory effect of each polyphosphate which was added at the beginnig or during the culture, was determined by measuring the optical density of the bacterial cell at 540nm and by viable cell count. The results from this study were as follows : 1. Polyphosphates were shown the growth inhibition of the Porphyromonas endodontalis. 2. The minimal inhibitory concentration(MIC) of polyphosphate was observed to be 0.04%. 3. Polyphosphates with chain lengths of 25 and 75 demonstrated the greatest inhibitory effect on the growth of Porphyromonas endodontalis. 4. Polyphosphates are bactericidal to Porphyromonas endodontalis, demonstrating the growth inhibition of the bacterium. The overall results suggest that use of polyphosphate may affect the growth of Porphyromonas endodontalis. Further studies will be needed to confirm the effect of Polyphosphate.

일본의 중심시가지 활성화에 관한 동향

윤상복,윤시운,오석기,이종식 동아대학교 건설기술연구소 1999 硏究報告 Vol.23 No.2

Currently, Suburbanization of commercial function in local and metropolitan city of Japan brought about doughnut phenomenon of city center, which made it seriously devastated. This study aims at the grasp of the depressed phenomenon caused by doughnut, providing a fundamental guide for activation of the central city in Korea through analysis of trends and strategy about it in Japan.

지하철 역사 승강장의 스크린도어 도입에 관한 연구

김상운,성기창,강병근 한국의료복지시설학회 2004 의료·복지 건축 Vol.10 No.2

In this paper, the problem of subway platform is analyzed and the alternative as a screen door is suggested. This paper aims to improve the facility law in subway platform. Because facility law related to platform is absent, the study scope is limited to detail design that is matched to rules. Field survey is performed to 300 persons that are 150 men and 150 women in Shingil station in which the screen door is established. Also the persons are used the screen door at least 3 times. It makes the field survey credible. The study is proceeded as follows ; First, the law related to platform, the problem of platform, and the plan and status of screen door are analyzed. Second, the definition, and composition of screen door are examined. Then, kinds of screen door is analyzed and the advantage and disadvantage of each kind of screen door are compared. Third, the necessity of establishing the, screen door is examined through field survey and error range of stop position is investigated. Through this flow, final results is abstracted. Direction of facility related to subway platform, applied objective and range are suggested based on this study. This study focuses the stability of platform, pleasantness, and energy saving and suggests facility improvement direction through introducing the screen door and further study.

Rhizopus oryzae를 이용한 바이오 디젤 생산

박상무,홍승준,이기영,김동운 全南大學校 觸媒硏究所 2002 觸媒硏究 論文集 Vol.23 No.-

Biodiesel was produced from soybean oil and methanol using fermentation broth or lipase. Production yield was 62% and 53.5% with purified Rhizopus oryzae lipase and Rhizopus oryzae broth respectively. This yield of biodiesel was highest in case of water content of 20%

부산시 중심시가지 활성화 방안에 관한 연구

윤상복,채성주,윤시운,오석기 동아대학교 건설기술연구소 2000 硏究報告 Vol.24 No.1

Urban management and C.B.D continuance's problem as a result of the extension of the city area and the existing commercial area's shrink due to city spatial structure lead to a lot of problems including doughnut phenomenon. The purpose of the this study is to figure out ways toward the strategies of commercial area prosperity that acts up positively to the multiple C.B.D by the change of urban spatial structure. The strategies of the commercial area prosperity in existing C.B.D were presented by dividing the recover of city function and the self-efforts for shopping facilities. To recover city function, first is to secure a settled population in hinterland. Second is to extend and complete of C.B.D function. Third is to improve that attractive element of C.B.D