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- 저자 : Sung Jean Park (검색결과 183 건)
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大學生의 思考技能의 診斷과 改善에 關한 硏究 : It's Diagnosis and Improvement
朴鎭玹,金武吉,金祥源,朴敬玉,羅東晋 全北大學校 學生生活硏究所 1988 學生生活硏究 Vol.16 No.-
Cognitive psychologists have taken a growing interest in reasoning skills as a primary goal of education. This study was accomplished as a part of elementary research on reasoning skills that have been pointed out as short comings of teaching of thinking. This study was composed of two substudies : one was to explore the ways to analyzing and diagnosing strategies for college students to apply to reasoning and problem solving, and the other was to examine the teachability of a normative strategy of thinking. In the first part of this study, we explored three alternatives to analyze thinking skills : cognitive process analysis, cognitive structure analysis, and cognitive style analysis ; and suggested the integrative use of them in diagnosing the cognitive skill of reasoning and problem solving. Model of cognitive process analysis was to devide the executive process of a specific task into several subtasks or components, measure the amount of effort, response time, and achievement level for each of them, and thereby analyze the strategies of thinking. Model of cognitive structure analysis was to present subject a specific task, instruct him to think aloud those ideas that came into his head during this solution, and analyze his cognitive structure on the base of his thinking-aloud. Finally, model of cognitive style analysis put more stress on tendency in thinking rather than ability in problem solving. In this regard, a alternative presented in this study was to analyze the strategies of thinking according to Baron's cognitive style model, in which process of thinking activity was devided into four phases : search of goal, search of possibility, search of evidence, and use of evidence. For each of them, the amount of time and effort that the indevidual invested and patterns of value that he grant would become criteria for judging the strategies that would become criteria for judging the strategies that he might use in the process of thinking activities for reasoning and problem solving. In result, this should correspond to measure biases on thinking. In general, main biases on thinking could be referred to insufficient search, search biased toward affirmative evidence, and oversensitivity to supporting evidence, which corresponded to compulsiveness vs. reflectiveness, dogmatism vs. open-mindedness, and authoritarianism, from a point of view on cognitive style, respectively. In the second part of this study, we examined the general principles of teaching thinking skills, based on human informations processing, and several training programs that have been developed with the purpose of improvement in thinking and reasoning skills. These programs were discussed into five categories: (1) cognitive operations approaches, (2) heuristics oriented approaches, (3) formal thinking approaches, (4) symbolic facility approaches, and (5) thinking-about-thinking approaches. Within these programs, the expansion of strategies and control of cognitive styles in reasoning and problem solving have become the main targets for improving of thinking skills. Therefore, this study was attempted to develop two training programs―referred to as Problem-Solving Training Program and Reasoning Skill Training Program respectively― for the purpose of improving these skills, and to test the effectiveness of these programs with college students. This study has shown the following facts : 1) It is necessary to teach the basic strategies for solving cognitive tasks of subject matters such as writing and mathematical problem for the purpose of improving thinking skills. 2) It is necessary to change the relatively general tendency in thinking process such as cognitive styles, in parallel with training of strategies. 3) Also, the training programs must consider indevidual defferences in activity parameters such as self-knowledge about problem solving, motivation, belief, etc. These facts seemed to imply the necessity of multi-dimensional approach to training the thinking skills.
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풍동실험을 위한 LabVIEW 응용 온라인 계측시스템의 개발
김봉근,장성태,이경용,박운진 한국기술교육대학교 2004 論文集 Vol.10 No.2
On-line measurement systems were newly developed for the performing effective wind tunnel experiments by utilizing the LabVIEW(Laboratory Virtual Instruments Engineering Workbench) system. As a result, instead of post-data-processing procedures based on Fortran programming which was commonly adopted in conventional measurement systems, wind tunnel experiments can be carried out on window-based PC operating systems and thus much time and effort required in analyzing fluid flow field can be successfully reduced. Furthermore, by utilizing the web publishing tool which is provided by the LabVIEW, it is possible to monitor and to control each measurement step via internet web pages from the remote area other than the laboratory in which experiments are carried out.
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Brain energy metabolism and multiple sclerosis: progress and prospects
Sung Jean Park,Ji Woong Choi 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.10
Multiple sclerosis (MS) is an autoimmune diseaseaccompanied with nerve pain and paralysis. Althoughvarious pathogenic causes of MS have been suggested,including genetic and environmental factors, how MS occursremains unclear. Moreover, MS should be diagnosed basedon clinical experiences because of no disease-specific biomarkerand currently available treatments for MS just canreduce relapsing frequency or severity with little effectson disease disability. Therefore, more efforts are requiredto identify pathophysiology of MS and diagnosis markers. Recent evidence indicates another aspect of MS pathogenesis,energy failure in the central nervous system (CNS). Forinstance, inflammation that is a characteristic MS symptomand occurs frequently in the CNS of MS patients can resultinto energy failure in mitochondria and cytosol. Indeed,metabolomics studies for MS have reported energy failurein oxidative phosphorylation and alteration of aerobic glycolysis. Therefore, studies on the metabolism in the CNS mayprovide another insight for understanding complexity of MSand pathogenesis, which would facilitate the discovery ofpromising strategies for developing therapeutics to treat MS. This review will provide an overview on recent progress ofmetabolomic studies for MS, with a focus on the fluctuationof energy metabolism in MS.
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Park, Sung Jean,Son, Woo Sung,Lee, Bong-Jin Molecular Diversity Preservation International (MD 2012 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.13 No.6
<P><I>Helicobacter pylori</I> (<I>H. pylori</I>) have a unique ability to survive in extreme acidic environments and to colonize the gastric mucosa. It can cause diverse gastric diseases such as peptic ulcers, chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, gastric cancer, <I>etc</I>. Based on genomic research of <I>H. pylori</I>, over 1600 genes have been functionally identified so far. However, <I>H. pylori</I> possess some genes that are uncharacterized since: (i) the gene sequences are quite new; (ii) the function of genes have not been characterized in any other bacterial systems; and (iii) sometimes, the protein that is classified into a known protein based on the sequence homology shows some functional ambiguity, which raises questions about the function of the protein produced in <I>H. pylori</I>. Thus, there are still a lot of genes to be biologically or biochemically characterized to understand the whole picture of gene functions in the bacteria. In this regard, knowledge on the 3D structure of a protein, especially unknown or hypothetical protein, is frequently useful to elucidate the structure-function relationship of the uncharacterized gene product. That is, a structural comparison with known proteins provides valuable information to help predict the cellular functions of hypothetical proteins. Here, we show the 3D structures of some hypothetical proteins determined by NMR spectroscopy and X-ray crystallography as a part of the structural genomics of <I>H. pylori</I>. In addition, we show some successful approaches of elucidating the function of unknown proteins based on their structural information.</P>
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Park, Seong Je,Lee, Ji Eun,Park, Jean Ho,Lee, Nak Kyu,Lyu, Min-Young,Park, Keun,Koo, Myung Sool,Cho, Sung Hwan,Son, Yong,Park, Suk-Hee Hindawi Limited 2018 Advances In Materials Science And Engineering Vol.2018 No.1
<P>Fused deposition modeling (FDM), one of the archetypal 3D printing processes, typically requires support structures matched to printed model parts that principally have undercut or overhung features. Thus, the support removal is an essential postprocessing step after the FDM process. Here, we present an efficient and rapid method to remove the support part of an FDM-manufactured product using the phenomenon of oxidative degradation of hydrogen peroxide. This mechanism was significantly effective on polyvinyl alcohol (PVA), which has been widely used as a support material in the FDM process. Compared to water, hydrogen peroxide provided a two times faster dissolution rate of the PVA material. This could be increased another two times by applying ultrasonication to the solvent. In addition to the rapidness, we confirmed that amount of the support residues removed was enhanced, which was essentially caused by the surface roughness of the FDM-fabricated part. Furthermore, we demonstrated that there was no deterioration with respect to the mechanical properties or shape geometries of the obtained 3D printed parts. Taken together, these results are expected to help enhance the productivity of FDM by reducing the postprocessing time and to allow the removal of complicated and fine support structures, thereby improving the design capability of the FDM technique.</P>
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Metabolite analysis in the type 1 diabetic mouse model
Park, Sung Jean Korean Magnetic Resonance Society 2021 Journal of the Korean Magnetic Resonance Society Vol.25 No.3
Type 1 diabetes mellitus (T1DM) is caused by insufficient production of insulin, which is involved in carbohydrate metabolism. Type 2 diabetes mellitus (T2DM) has insulin resistance in which cells do not respond adequately to insulin. The purpose of this study was to estimate the characteristics of type 1 diabetes using streptozotocin-treated mice (STZ-mouse). The sera samples were collected from the models of hyperglycemic mouse and healthy mouse. Based on the pair-wise comparison, five metabolites were found to be noticeable: glucose, malonic acid, 3-hyroxybutyrate, methanol, and tryptophan. It was very natural glucose was upregulated in STZ-mouse. 3-hyroxybutyrate was also increased in the model. However, malonic acid, tryptophan, and methanol was downregulated in STZ-mouse. Several metabolites acetoacetate, acetone, alanine, arginine, asparagine, histidine, lysine, malate, methionine, ornithine, proline, propylene glycol, threonine, tyrosine, and urea tended to be varied in STZ-mouse while the statistical significance was not stratified for the variation. The multivariate model of PCA clearly showed the group separation between healthy control and STZ-mouse. The most significant metabolites that contributed the group separation included glucose, citrate, ascorbate, and lactate. Lactate did not show the statistical significance of change in t-test while it tends to down-regulated both in DNP and Diabetes.
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Park, Sung-Jean,Kim, Ji-Sun,Son, Woo-Sung,Ahn, Hee-Chul,Lee, Bong-Jin Korean Society for Biochemistry and Molecular Biol 2003 Journal of biochemistry and molecular biology Vol.36 No.5
One of the small proteins from Helicobacter pylori, acyl carrier protein (ACP), was investigated by NMR. ACP is related to various cellular processes, especially with the biosynthesis of fatty acid. The basic NMR resonance assignment is a prerequisite for the validation of a heterologuous protein interaction with ACP in H.pylori. Here, the results of the backbone $^1H$, $^{15}N$, and $^{l3}C$ resonance assignments of the H. pylori ACP are reported using double- and triple-resonance techniques. About 97% of all of the $^1HN$, $^{15}N$, $^{13}CO$, $^{13}C{\alpha}$, and $^{13}C{\beta}$ resonances that cover 76 of the 78 non-proline residues are clarified through sequential- and specific-assignments. In addition, four helical regions were clearly identified on the basis of the resonance assignments.
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Conformational changes of fibrinogen in dispersed carbon nanotubes
Park, Sung Jean,Khang, Dongwoo Dove Medical Press 2012 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.7 No.-
<P>The conformational changes of plasma protein structures in response to carbon nanotubes are critical for determining the nanotoxicity and blood coagulation effects of carbon nanotubes. In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes, which correspond to the water dispersity or hydrophilicity of carbon nanotubes, can induce conformational changes in the fibrinogen domains. Also, elevation of carbon nanotube density can alter the secondary structures (ie, helices and beta sheets) of fibrinogen. Furthermore, fibrinogen that had been in contact with the nanoparticle material demonstrated a different pattern of heat denaturation compared with free fibrinogen as a result of a variation in hydrophilicity and concentration of carbon nanotubes. Considering the importance of interactions between carbon nanotubes and plasma proteins in the drug delivery system, this study elucidated the correlation between nanoscale physiochemical material properties of carbon nanotubes and associated structural changes in fibrinogen.</P>
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