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배양액 내의 교원성 기질이 피부 섬유모세포의 DNA 및 단백질 합성에 미치는 영향
이종원,곽승일,심형곤,이종건,변준희 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.2
Collagen is the major component of scar tissue. Considerable progress of fibroblast growth kinetics and of collagen synthesis has been achieved in the past decade. We have been interested in fibroblasts activities as they are expressed by cells cultured in collagen substrate. This study is to examine the Effects of collagen substrate and peptide growth factors in culture medium on DNA and protein synthesis of human dermal fibroblast. Collagen, interleukin-1(IL-1) and transforming growth factor-β(TGF-β) were added to fibroblast culture media according to the designed experiment model and DNA and protein synthesis were measured by [³H]-thymidine, [³H]-leucine, and [³H]-proline incorporation method the morphological features of fibroblasts were observed by light microscape. The results were as follows; 1) There were significant deceases of DNA and protein synthesis of cultured fibroblasts in the presence of collagen substrate compared with those in control groups ( p<0.01 ) 2) DNA and protein synthesis were decreased as dose dependent manner of collagen density in culture media. 3) Morphological features of fibroblasts became less stellate and flat, more spindle-like in the presence of collagen. 4) In responsiveness to IL-1, Collagen non-treated groups responded to IL-1 but collagen treated groups were unresponsive to IL-1 (P<0.05). 5) Cells in collagen non-treated groups responded to TGF-β as dose-related manner ( P<0.01 ). Collagen treated groups responded to TGF-β but did not show TGF-β dose-dependent relationship. In conclusion, Collagen substrate in the culture medium could lower the DNA and protein synthesis of fibroblasts. Cells in Collagen substrate were unresponsive or less responsive to peptide growth factors than those in non-collagen substrate.
이상윤,조성일,백도명,변창범,김미정,박경근,임상혁,양길승,황창국,전형준 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2
목적: 2000년도에 이황화탄소 중독증 환자들과 대조군의 심박동수 변이를 비교하여 이황화탄소 중독증 환자들의 심박동수 변이가 대조군에 비해 유의하게 낮다는 연구보고가 있었다. 당시의 연구가 이황화탄소 노출이 중단된 상태에서 이황화탄소 중독자들의 건강 문제를 연구했다는 점에 의의가 있으나 연구 결과를 해석하는데 있어 제한점들이 있었다. 이 연구는 2000년도에 수행하였던 연구의 제한점을 극복하고 이황화탄소 노출이 중단된 이후의 이황화탄소 중독자들의 심혈관계 상태를 심박동수 변이를 이용하여 평가해보고자 하였다. 방법: 이황화탄소 중독증으로 진단받은 환자 122명과 환자군의 연령대와 성별 빈도에 따라 무작위 추출한 112명을 대조군으로 선정하였다. 자기 기입식 설문지와 건강검진을 통해 연령, 성별, 신장, 체중, 흡연, 음주, 규칙적 운동, 질병력, 직업력, 흉부 방사선 촬영, 심전도 측정을 실시하였다. 연구 대상자들은 의자에 앉힌 상태에서 5분 동안 심박동수 변이를 측정하였다. 이 연구에서 측정한 심박동수 변이 지표들은 정상 RR간격의 표준편차(standard deviation of all norma-to-normal intervals, SDNN), 인접한 RR간격들의 차이를 제곱의 합의 평균의 제곱근(square root of the mean of the sum of squares of differences between adjacent normal-to-normal intervals, RMSSD). 저주파영역(low frequency power, LF: 0.04~0.15Hz), 고주파 영역 (high frequency power, HF:0.15~0.4Hz), 전체 주파수 강도(total power, TP), 저주파/고주파 비 (LF/HF ratio)이다. 결과: 단변량 분석에서 이황화탄소 중독자들의 모든 심박동수 변이 지표들이 대조군에 비하여 낮았다. 다중선형회귀분석에서 이황화탄소 중독은 RMSSD를 유의하게 감소시키는 것으로 나타났다.(P<0.05). 결론: 이 연구는 이황화탄소 노출이 중단된 상태에서도 이황화탄소 중독자들에게 심혈관계와 관련된 건강문제가 있을 수 있음을 시사한다. Objectives: A previous study conducted in 2000 measuring the heart rate variability (HRV) of carbon disulfide (CS_(2))-poisoned subjected suggested that their HRV was reduced after exposure cessation. However, the study was limited by the following procedural limitations: (1) only 71 CS_(2)-poisoned subjects participated, (2) no females participated, and (3) the CS_(2)-poisoned subjects were older than the controls. This study was therefore conducted to overcome these limitations of the earlier study. Methods: The study subjects comprised 122 retired workers with CS_(2) poisoning and the same number of age- and sex-matched controls. Information on individual age, sex, height, wight, smoking history, alcohol drinking, regular exercise, medical and occupational history, chest x-ray, and ECG recording of the two groups was collected though a self-administered questionnaire and a medical examination. Standard Deviation of NN intervals (SDNN), Root-Mean-Square of Successive Differences (RMSSD), Total Power (TP), Low Frequency (LF), High Frequency (HF), and LF/HF ratio were measured as HRV indices for 5 minutes in the sitting position. Results: Univariate analysis revealed that all HRV indices of CS_(2)-poisoned subjected were lower than those of the controls. Multiple linear regression analysis showed that CS_(2) poisoning had negative association with all HRV indices and that its association with RMSSD was statistically significant(P<0.05). Conclusions: This study suggests that CS_(2)-poisoned subjects continue to have reduced HRV, even though the exposure has ceased.
( Hye Won Park ),( Jeong Sik Byeon ),( Suk Kyun Yang ),( Hyun Soo Kim ),( Won Ho Kim ),( Tae Il Kim ),( Dong Il Park ),( Young Ho Kim ),( Hyo Jong Kim ),( Moon Sung Lee ),( Il Kwon Chung ),( Sung Ae J 대한소화기기능성질환·운동학회 2009 Gut and Liver Vol.3 No.1
Background/Aims: The incidence of colorectal cancer is increasing in Korea, but the epidemiology of colorectal neoplasm is not clearly defined. We aimed to elucidate the prevalence of colorectal neoplasm in average-risk Koreans and explore the underlying risk factors. Methods: A large-scale, multicenter, prospective study was conducted. Of the 19,460 subjects who underwent colonoscopy at 11 university hospitals, we analyzed 3,951 consecutive asymptomatic adults with no risk factors for colorectal cancer. Results: The subjects were aged 52.1±11.6 years (mean±SD) and 60.1% of them were men. The prevalences of colorectal neoplasm and advanced neoplasm were 33.3% and 2.2%, respectively. The prevalence of a neoplasm increased with age (trend: p<0.001) and was higher in males (p<0.001). The prevalence of a proximal neoplasm was higher in subjects with a distal neoplasm than in those without a distal neoplasm (11.9% vs. 5.4%, p<0.001). However, 150 (52.1%) of the 288 subjects with a proximal neoplasm had no distal neoplasm. Conclusions: The overall prevalence of colorectal neoplasm in asymptomatic average-risk Koreans is comparable with that in Western countries. Being male and older are associated with a higher risk of colorectal neoplasm. Over half of proximal neoplasms are not associated with any distal sentinel lesions. (Gut and Liver 2009;3:35-40)
노인에서 대장 내시경 선별 검사의 임상적 효용성: 대한장연구학회 다기관 공동연구
박성근 ( Sung Geun Park ),박동일 ( Dong Il Park ),김영호 ( Young Ho Kim ),김현수 ( Hyun Soo Kim ),김원호 ( Won Ho Kim ),김태일 ( Tae Il Kim ),김효종 ( Hyo Jong Kim ),양석균 ( Suk Kyun Yang ),변정식 ( Jeong Sik Byeon ),이문성 ( Moo 대한장연구학회 2008 Intestinal Research Vol.6 No.1
Background/Aims: Currently, screening colonscopy is widely performed in the medical field. The initial time of screening is recommended at an age of 50 years, but the age to cease screening is unknown. Accordingly, we have investigated the diagnostic yield of colonoscopy according to indications in the elderly, and we evaluated if screening colonoscopy is useful in the elderly. Methods: We recruited asymptomatic individuals undergoing screening colonoscopy according to age (2830 subjects aged 50-74 years and 111 subjects ≥75 years-old), The colonoscopy findings of the study subjects were compared. In addition, colonoscopy findings of asymptomatic subjects more than 75 years-old were compared with the findings of symptomatic subjects with the same age. Results: The yield for overall neoplasia and advanced adenoma was higher in the group of subjects ≥75 years-old than in the 50-74 years age group (overall adenoma: 49.54% versus 24.98%, p<0.001; advanced adenoma: 16.2% versus 8.23%, p=0.003). The overall frequency of neoplasms was higher in asymptomatic subjects ≥75 years-old than in symptomatic subjects ≥75 years-old (49.54% versus 28.19%, p<0.001). Conclusions: The prevalence of advanced adenoma increased with age. Screening colonoscopy was still significantly effective in elderly subjects ≥75 years-old. The lack of a decline in the frequency of adenoma, including advanced adenoma, justifies continuing screening colonoscopy in the elderly. (Intest Res 2008;6:25-30)
전상린 ( Sang Rin Jeon ),변화근 ( Hwa Kun Byeon ),최청일 ( Cheong Il Choi ) 한국하천호수학회 2002 생태와 환경 Vol.35 No.5
영월댐 담수예정지역인 동강의 어류상과 어류군집을 밝히기 위하여 1998년 추계 및 1999년 춘계와 하계에 본류의 10개 정점과 지류의 5개 정점에서 조사를 실시하였다. 총 32종의 석이 확인되었으며 일차담수어는 26종, 주연성 담수어는 6종으로 일차담수어의 구성비가 매우 높았으며 어종별로는 갈겨니가 계절별로 55.24%, 48.73%, 48.70%로 매우 높은 구성비를 나타내고 있었다. 우점종은 본류정점에서는 모두 Zacco temmincki이었고 지류정점에서 Moroco oxycephalus와 Moroco kumgangensis이었으며 아우점종은 대부분의 조사정점에서 Coreoleuciscus splendidus와 Microphysogobio longidorsalis이었으며 우점도지수는 전 조사정점에서 비교적 고르게 높았다. 유사도지수를 비롯한 각 종의 생태지수는 대체로 지류와 본류의 정점간에 차이를 나타내어 서식환경의 차이를 반영하고 있었다. The fish fauna and community of the Dong River was studied at 15 stations along the Dong River Valley. The study took place main stream (10 stations) and the branch stream (5 stations) from 1998, autumn to 1999, spring and summer. Total of 32 species (primary freshwater: 26 species, peripheral freshwater: 6 species) were found with the primary freshwater fishes being highest. The dominant species in the main stream was Zacco temmincki, Moroco oxycephalus and Moroco kumkangensis found in the branch stream. The subdominant species, Coreoleuciscus splendidus and Microphysogobio longidorsalis were found at all surveyed stations. All indices including the similarity index showed the differences between the main stream and branch stream, which in turn, showed the difference in habitats. The occurrence of Korean endemic species (16 species) was very high and among these 1 species was identified as qualifying for possible designation as a natural monument category; 5 species also qualified for possible designation as being special for wildlife category, and 2 species were identified for designation required to potect under a wildlife category. It is suggested that the conservation for fish fauna in this area should be emphasized.