효율적인 군 전직지원체제 정립 방안

정철영,고재관,황원채,윤희철,박가열,김재호,이성식,김동승,표성일,이건남,양안나,최수정,김은석 한국직업능력개발원 2008 직업능력개발연구 Vol.11 No.1

이 연구의 목적은 제대군인에 대한 효율적인 전직지원을 위해서 현행 전직지원 프로세스에 대한 개선 안과 이에 따른 국방부, 국가보훈처 등 제대군인 전직지원관련 기관 간의 역할분담 및 연계방안에 대해서 제안하는 것이다. 연구는 크게 세 가지 과정을 거쳤다. 첫째, 국내 군 전직지원 실태를 분석하여 문제점과 시사점을 도출하였다. 둘째, 이러한 문제점과 시사점, 군 전직지원 선행연구를 종합하여 효율적인 군 전직지원 프로세스 안을 제시하였다. 셋째, 구축한 군 전직지원 프로세스 안에 따라 주요 군 전직지원 관련 기관인 국방부, 국가보훈처의 역할 분담 안을 제안하였다. This study aims to suggest an improvement plan for the support process of effective occupation change for discharged soldiers and then role assignments among related institutions for supporting discharged soldiers such as Ministry of Defense, Ministry of Patriots and Veterans Affairs, Ministry of Labor and the cooperation plan among the institutions. The study was made in three steps. First, after analyzing currents support facts and status for discharged soldiers, it induced its problems and implications. Second, integrating the findings of previous studies related to support plan on occupation changes for the discharged soldiers, Problems and implications mentioned above, it constructed effective occupation change process for discharged soldiers. Then, according to the established process, it suggested role assignments such as Ministry of Defense, Ministry of Patriots and Veterans Affairs, Ministry of Labor.

성장기 흰쥐에서 단백질 장기간 알코올 투여가 인슐린 분비능 및 감수성에 미치는 영향

윤용석,허갑범,이현철,임승길,김경래,송영득,안철우,차봉수,이해일,성제경 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.1

Background: This investigation was performed to examine the combined effects of protein malnutrition and chronic moderate amount of alcohol intake on insulin secretory capacity and sensitivity in growing rats. Methods: Weanling 4-week-old male Sprague-Dawley rats were fed low protein [5%, (wt/wt)] or control (C, 20%) diet from 4 to 12 weeks and alcohol (5 g/kg/d) or saline gavage from 8 to 12 weeks. All rats were divided into the 4 groups according to different diet protocols: group I (protein-deficient alcohol rats), group II (protein-deficient saline rats), group III (protein-sufficient alcohol rats), and group IV (protein-sufficient saline or control rats). At the age of 12 weeks, we determined the insulin secretory capacity and sensitivity in the 4 different diet groups. Results: The results are summarized as following; 1. Normal weight gain was nearly completely arrested in protein-deficient rats compared to control rats. In protein-sufficient rats, chronic alcohol intake decreased body weight gain. Pancreatic weight adjusted with body weight was not different among the 4 groups, but epididymal fat weight adjusted with body weight was decreased in group II compared to group IV. 2. Intraperitoneal glucose tolerance was improved in group I compared to the other groups. Insulin responses to glucose challenge were markedly decreased in group II compared to group IV, but not in group I. 3. Glucose disposal rate during euglycemic clamp test was diminished in group II compared to group IV, but there were no differences between group I and group IV. Glycogen synthase activities of skeletal muscle after 2 hour hyperinsulinemic state were not different among the 4 groups. 4. There were no differences of reserved insulin content of whole pancreas adjusted with pancreas weight among the 4 groups. 5. In light microscopic findings of pancreatic islets, sizes of islets, islet cells and nuclei were decreased in protein-deficient rats compared to control rats. However, the sizes of islet cells and nuclei were further decreased in group II compared to group I. Conclusion: These results suggest that impaired insulin secretion and decreased insulin sensitivity due to protein malnutrition can be restored by chronic, moderate amount of alcohol intake, but these beneficial effects may not be appeared in protein-sufficient state. Therefore, the chronic alcohol intake differently influences glucose metabolism according to individual nutritional status, and further studies for the effects of alcohol intake in lean diabetic patients are required to extrapolate these results in human.

Antinociceptive Effects of Intrathecal Metabotropic Glutamate Receptor Compounds and Morphine in Rats

Choi, Jeong II,Lee, Hyung Kon,Chung, Sung Tae,Kim, Chang Mo,Bae, Hong Beom,Kim, Seok Jai,Yoon, Myung Ha,Chung, Sung Su,Jeong, Chang Young The Korean Pain Society 2005 The Korean Journal of Pain Vol.18 No.1

Background: Spinal metabotropic glutamate receptors (mGluRs) and opioid receptors are involved in the modulation of nociception. Although opioid receptors agonists are active for pain, the effects of the compounds for the mGluRs have not been definitely investigated at the spinal level. We examined the effects of the intrathecal mGluR compounds and morphine in the nociceptive test, and then we further clarified the role of the spinal mGluRs. In addition, the nature of the pharmacological interaction after the coadministration of mGluRs compounds with morphine was determined. Methods: Catheters were inserted into the intrathecal space of male SD rats. For the induction of pain, $50{\mu}l$ of 5% formalin solution or a thermal stimulus was applied to the hindpaw. An isobolographic analysis was used for the evaluation of the drug interaction. Results: Neither group I mGluR compounds nor group III mGluR compounds produced any antinociceptive effect in the formalin test. The group II mGluR agonist (APDC) had little effect on the formalin-induced nociception. The group II mGluR antagonist (LY 341495) caused a dose-dependent suppression of the phase 2 flinching response on the formalin test, but it did not reduce the phase 1 response of the formalin test nor did it increase the withdrawal latency of the thermal stimulus. Isobolographic analysis revealed a synergistic interaction after the intrathecal delivery of a LY 341495-morphine mixture. Conclusions: These results suggest that group II mGluRs are involved in the facilitated processing at the spinal level, and the combination of LY 341495 with morphine may be useful to manage the facilitated pain state.

급성 췌장염 환자에서 양성자펌프억제제의 효과-예비 연구

유정환 ( Jeong Hwan Yoo ),권창일 ( Chang Ii Kwon ),유광호 ( Kwang Ho Yoo ),윤해리 ( Har Ry Yoon ),김원희 ( Won Hee Kim ),고광현 ( Kwang Hyun Ko ),홍성표 ( Sung Pyo Hong ),박필원 ( Pil Won Park ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.6

목적: 급성 췌장염의 발생에는 다양한 기전이 관여하고 있고 활성산소가 중요한 역할을 한다고 알려져 있다. 널리 사용되고 있는 양성자펌프억제제인 pantoprazole은 췌장의 소화효소의 분비를 간접적으로 억제하는 작용 외에도 활성산소에 대한 항산화효과와 항염증효과를 가지고 있다. 이번 연구는 이런 pantoprazole의 사용이 급성 췌장염의 임상 경과에 어떤 영향을 미치는지 알아보고자 하였다. 대상 및 방법: 2011년 3월부터 2012년 5월까지 급성 췌장염으로 입원한 환자 중 위식도 역류질환이 동반된 40명을 대상으로 전향적 무작위 배정으로 연구하였다. 20명씩 두 군으로 나누어 한 군에서는 pantoprazole을 투여하였고 다른 군에서는 사용하지 않았다. Pantoprazole은 금식기간 동안에는 하루 2번 40 mg을 정맥 내로 투여하였고 식사 시작 후에는 하루 2번 40 mg을 퇴원할 때까지 경구 투여하였다. 다른 급성 췌장염의 치료는 양 군에서 동일하게 사용되었다. 혈청 amylase, lipase 등의 혈액학적 검사와 APACHE II 점수를 연속적으로 측정하였고 입원 당시 복부 전산화단 층촬영을 시행하여 CT 중증도 지수를 측정하였다. 결과: 양 군 간에 기준 특성, 혈액검사, APACHE II 점수, CT 중증도 지수에서 유의한 차이를 보이지 않았다. Pantoprazole 투여군에서 평균 입원일은 7.4일, 경구 섭취까지 걸린 시간은 69.0시간, 복통이 호전될 때까지 걸린 시간은 59.7시간이었다. APACHE II 점수는 입원 당시에는 3.15이었고 퇴원 시에는 2.35이었다. Pantoprazole을 투여하지 않은 군에서는 평균 입원일은 7.6일, 경구 섭취까지 걸린 시간은 71.4시간, 복통이 호전될 때까지 걸린 시간은 61.8시간이었다. APACHE II 점수는 입원 당시에는 4.4이었고 퇴원 시에는 2.85이었다. 모두 양 군에서 통계학적으로 유의한 차이를 보이지 않았다. 결론: Pantoprazole을 이용한 치료가 급성 췌장염의 경과에 어떤 개선도 보이지 못했다. 그러나 예비 연구라는 점을 고려했을 때, 더 큰 규모의 전향적 무작위 배정 임상연구로 검증이 필요하겠다. Background/Aims: Oxygen free radicals play an important role in acute pancreatitis. Pantoprazole as a proton pump inhibitor (PPI) has pancreatic anti-secretory effect and a pronounced inhibitory reactivity towards hydroxyl radicals. The objective of the study was to investigate the effect of pantoprazole on the course of acute pancreatitis. Methods: We conducted a prospective randomized trial involving 40 patients with acute pancreatitis. Patients were divided into two groups. One group received PPI and the other group did not receive PPI. In the PPI group, patients received pantoprazole 40 mg intravenously twice a day for fasting time, and then 40 mg orally twice a day until discharge. Results: There were no significant differences in baseline characteristics and laboratory markers between two groups. In the pantoprazole group, mean hospital stay was 7.4 days, time to start oral intake was 69.0 hours, and time to pain relief was 59.7 hours. Acute physiology and chronic health evaluation (APACHE) II score was 3.15 at admission day and 2.35 at discharge. On the other hand, in the non-pantoprazole group, mean hospital stay was 7.6 days, time taken to start oral intake was 71.4 hours, and time taken to pain relief was 61.8 hours. APACHE II score was 4.4 at admission and 2.85 at discharge. However, there were no significant differences between two groups. Conclusions: Treatment with pantoprazole did not have influence on the clinical course of acute pancreatitis. But, considering it was a pilot study, large scale prospective trials will be needed.

건강한 한국 성인에서 ALDH2 유전형에 따라 Metadoxine(Alcotel)이 알코올의 약동학 및 약역학에 미치는 영향

윤진상,윤보현,이용복,신일선,정재성,정원태,시영화 전남대학교 약품개발연구소 2000 약품개발연구지 Vol.9 No.1

Objectives : Mctadoxine is known to have accelerated the metabolism of alcohol in previous studies with Caucasian subjects. The purpose of this study was to evaluate the effects of metadoxine on alcohol pharmacokinetis and pharmacodynamics in normal Korean adults according to the low-Km aldehyde dehydrogenase(ALDH2) genotypes. Methods : Twenty healthy male volunteers(half with active ALDH2*1/*1 : active group, the other with inactive ALDH2*1/*1 : inactive group) were selected by genotyping. In a double-blind, counterbalanced design, can subject ingested 0.5g of alcohol per ㎏ of body weight with pretreatment of metadoxine or placebo on 2 acparate occasions. Blood alcohol concentration by breathanalyzer(BrAC), vital signs, negative physiological response and performance function using a battery of tests(critical flicker fusion threshold : CFFT, choice reaction time : CRT, compensatory tracking task : CTT and digit-symbol substitution : DSS) were measured at baseline and repeatedly over 3-hour period after intake of alcohol. Results : Among the pharmacokinetic parameters, Vmax and Km were significantly increased with pretreatment of metadoxine in both the active and inactive ALDH2 groups, but the ratio of Vmax/Km was decreased. In terms of pharmacodynamics, the pretreatment of metadoxine produced a significant improvement of performance such as CFFT and DSS in the active ALDH2 group, but did not in the inactive ALDH2 group. Conclusions : It may be concluded that metadoxine has little effect on alcohol metabolism in both groups with respect to phamacokinetics on the basis of BrAC. The pharmacodynamic results, however, indicated that metadoxine might be partially effective in counteracting the impairing effects of alcohol on the performance in the active ALDH2 group.

급성 골수성 백혈병에서 AML1/ETO 융합유전자 발현과 임상양상

이성배,김영일,윤휘중,김시영,조경삼 大韓血液學會 1998 大韓血液學會誌 Vol.33 No.3

Self-compatible Pear ‘Wonkyo Na-jasoojung 4 and 5’

II Sheob Shin,Hae Sung Hwang,Kang Hee Cho,Se Hee Kim,Sam Seok Kang,Yoon Kyeong Kim 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.10

New ADA Criteria in the Korean Population : Fasting Blood Glucose is not Enough for Diagnosis of Mild Diabetes Eespecially in Theelderly

Yoon Hee Choi,Yu Bae Ahn,Kun Ho Yoon,Moo II Kang,Bong Yun Cha,Kwang Woo Lee,Ho Young Son,Sung Ku Kang 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.3

Background : To compare the 1997 American Diabetes Association (ADA) criteria with the 1985 World Health Organization (WHO) criteria in categorization of the diabetes diagnostic status of Koreans and to define clinical characteristics of subjects diagnosed

Self-compatible Pear ‘Wonkyo Na-jasoojung 4 and 5’

II Sheob Shin,Hae Sung Hwang,Kang Hee Cho,Se Hee Kim,Sam Seok Kang,Yoon Kyeong Kim 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.5

Lithium 유지요법

이상연,곽동일,이병윤 大韓神經精神醫學會 1975 신경정신의학 Vol.14 No.3

Many studies of lithium maintenance treatment for the manic-depressive patients were reported. In order to estimate the effectiveness of lithium maintenance treatment as a preventinn of recurrence of maic-depressive attacks. the authors selected 12 cases of maic-depressive psychoses who had more than one attack in the past several years and under treatment of lithium maintenance treatment in the Department of Neuropsychiatry, Woo sok Hospital, Korea University. The result were as follows: 1. Only 4 patients among 11 cases who has no recurrence so far up to the date of this reported showed 0.6 -1.2mEq/L in serum Lithium level. 2. One patient who was under control for about 12 months with 600mg of lithium carbonate had another attack again 10 months after dropping out of the maintenance treatment 3. There is no evidence of interrelations between body weight of the patients, serum lithium level and maintenance dosage.