관동맥 질환 환자에서 전산화단층촬영상의 복부지방 분포 및 형광안저 촬영

한혜자,홍종면,차상훈,김동운,남기병,최미영,강세웅,박남규,이석재 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.2

배경 및 목적 : 죽상경화증의 원인 인자중 하나인 복부지방의 축적도를 복부 전산화 단층 촬영술로 정량화 하여 관동맥 질환과의 상관 관계를 살펴보고자 하려고, 또한 형광 안저 촬영 검사상의 죽상 경화증 정도와 관동맥 질환과의 상관 관계를 알아보고자 하였다 대상 및 방법 : 관동맥 조영술을 시행한 환자중 관동맥조영술 소견상 50% 이상의 협착이 있는 경우를 관동맥 질환군(n=15)으로 정의하였고, 관동맥 조영술 소견상 관동맥 질환이 없고 허혈성 뇌혈관질환, 당뇨병 및 고혈압이 없는 환자들을 대조군(n=11)으로 하였다. 배꼽 위치에서 복부 전산화 단층 촬영을 시행하여 총 복부 지방면적(total abdomen fat area, TAFA). 복강내 지방면적(abdomen visceral fat area, AVFA) 및 복부 피하지방면적(abdomen subcutaneous fat area, ASFA)을 측정하였고, 그 비를 구하여 비교 분석하였다 또한 형광 안저 촬영 검사를 시행하여 동-정맥비와 동-정맥교차수 및 팔망막 순환기 시간을 측정하여 비교 분석하였다. 결과 : 1) 복부 전산화 단층 촬영 : 대조군과 관동맥 질환군은 복강내 지방면적/(AVFA/TAFA)은 각각 53.9±8.3, 56.1±8.5으로 통계적으로 유의한 차이가 없었고, 또 복강내 지방면적/복부 피하지방면적(AVFA/ASFA)도 각각 0.90±0.30, 0.82±0.26으로 통계적으로 유의한 차이가 없었다 (p>0.05). 2) 형광안저 촬영 검사 ; 대조군과 관동맥 질환군에서 동-전맥비(%)는 각각 72.1±4.9, 62.5±6.1, 동-정맥 교차수는 0.3±0.5, 1.1±1.1, 팔망막 순환기 시간(msec)은 15.3±1.8, 17.8±4.0으로 세 지표 모두에서 통계적으로 유의한 차이가 있었다 (p<0.05). 결론 : 관동맥 질환 환자에서 전산화 단층촬영을 이용하여 구한 복부지방의 분포양상(복강내 지방의 구성 비율 등)은 정상 대조군과 차이가 없었다. 관동맥 질환 환자와 정상 대조군에서 형광 안저 촬영 검사로 측정한 동정맥 직경비, 동정맥교차현상수 및 팔망막순환시간은 각각 통계적으로 의미 있는 차이가 있었다 Background : We quantitatively evaluated the abdominal fat distribution by computed tomography(CT) in coronary artery disease patients and the findings of fluorescence angiography in coronary artery disease patients. Methods: Among the patients who were done coronary angiography(CAG), the control group(n=11) has no angiographically significant stenosis(<50%) and the coronary artery disease(CAD) group(n=15) has more than one significant stenosis(>52%). We examined abdominal CT at umbilicus level and fluorescence angiography in all patients. In abdominal CT, we calculated total abdominal fat area(TAFA), abdominal visceral fat asea(AVFA) and abdominal subcutaneous fat area(ASFA) and their ratios. In fluorescence angiography, we calculated that artery-vein ratio(AV ratio), artery-vein cross number(AV cross No) and antecubital-retinal circulation time. Results: 1) Abdominal CT A. AVFA/TAFA(㎡) ; Control group : CAD group = 53.9±8.3 : 56.1±8.5 (p〉0.05) B. AVFA/ASFA(㎡) ; Control group : CAD group = 0.90±0.30 : 0.82±0.26 (p〉0.05) 2) Fluorescence angiography A. AV ratio(%) ; Control group : CAD group = 72.1±4.9 : 62.5±6.1 (p〈0.05) B. AV cross No ; Control group : CAD group = 0.3±0.5 : 1.1±1.1 (p〈0.05) C. Antecubital - retinal circulation time(ms) Control group : CAD group = 15.3±1.8 : 17.8±4.0 (p<0.05) Conclusion : There was significant association between the FAG findings and CAG findings but there was no significant association between the abdominal fat distribution by abdominal CT and CAG findings.

최종당화산물이 혈관평활근세포 증식에 미치는 영향 및 그 기전

송진영,임성희,서지영,조영중,유형준,박성우,임자혜 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2

연구배경:혈관평활근세포의 증식은 죽상경화증의 주된 변화로 당뇨병과 동반된 죽상경화증에서도 관찰된다. 최종당화산물(AGE)은 NO와 결합함으로써 이의 혈관평활근세포 증식 억제 작용을 차단한다고 알려져 있으나. 혈관평활근세포에도 최종당솨산물에 대한 수용체가 발견되었음에도 불구하고 최종당화산물이 혈관평활근세포의 증식에 직접 미치는 영향 및 기전에 대하여는 잘 알려져 있지 않다. 본 연구에서는 최종당화산물이 백서 대동맥에서 분리 배양한 혈관평활근세포 증식에 미치는 영향 및 그 기전을 알아 보고자 하였다. 방법:혈관평활근세포는 male Sprague­Dawley 백서의 대동맥에서 분리하여 10% FBS­DMEM 내에서 배양하였고, 세포 증식 실험은 24­well plate에 well당 1×10⁴세포를 0.1% FBS­DMEM(with or without AGE­BSA, anti­AGE antibody, MAP kinase inhibitor, antioxidants)내에서 배양하여 48시간후 MTT assay로 세포 증식을 측정하였다. 결과:AGE­BSA를 2.5, 5.0㎍/mL 농도로 첨가한 경우 혈과평활근세포 수는 AGE­BSA를 가하지 않은 대조군에 비해 1.5, 1.6배 증가되었다. 이러한 AGE­BSA에 의한 혈관평활근세포 증식 촉진 효과는 anti­AGE antibody(100㎍/mL), MAP kinase 억제제인 PD98509(50μM)및 항산화제인 N­acetylcysteine(1μM)이나 butylated hydroxyanisole(10μM)에 의해 차단되었다. 결론:이러한 결과는 AGE가 혈관평활근세포에서 산화 스트레스의 변화를 초래하고 MAP kinase 경로를 통해 혈관평활근세포의 증식 및 죽상경화증의 발생에 기여할 가능성을 뒷받침한다. Background : Diabetes mellitus is an epidemiologically proven risk factor for atherosclerosis. Advanced glycation end products (AGE) have been implicated in the pathogenesis of many diabetic vascular complications. AGE not only change the physicochemical properties of proteins, but also AGE on the vascular smooth muscle cells (VSMCs) have not been fully explained despite of presence of an AGE-receptor on the VSMCs. Methods : In order to test whether AGE promotes atherosclerosis by stimulation of the growth promoting signal transduction pathways in the VSMCs, the proliferation of rat aortic VSMCs cultured in the presence of AGE-BSA with/without anti-AGE antibodies, the MAP kinase inhibitor and antioxidants was measured. The VSMCs (1x10^4 cells in 24-well plates) isolated from the aorta of Sprague-Dawley rats were incubated for 48 hours and the proliferation was assessed by a MTT assay. Results : AGE-BSA increased the proliferation of rat aortic VSMCs by 1.5~1.6 fold at the ㎍/mL level. The stimulatory effect of AGE-BSA (5㎍/mL) was blocked by the anti-AGE antibodies (100 ㎍/mL). PD98059 at 50? inhibited the AGE-BSA-induced VSMC proliferative response of the VSMCs to AGE. AGE-BSA-induced VSMC proliferation was also attenuated by N-acetylcysteine (1?) and butylated hydroxyanisole (10?), implying that increased intracellular oxidative stress might be also involved in the proliferative response to AGE. Conclusion : These results suggest AGE play a role in diabetic atherosclerosis by stimulating of the growth promoting signal transduction pathways in the VSMCs (J Kor Diabetes 26:91~99, 2002).

제초제 MCPP에 의한 화학적 화상

김은경 ( Eun Kyung Kim ),김혜성 ( Hei Sung Kim ),박영민 ( Young Min Park ),김형옥 ( Hyung Ok Kim ),이준영 ( Jun Young Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.10

MCPP (2-(4-chloro-2-methyl phenoxy) propionic acid) is a phenoxy herbicide found in many household weed killers and lawn fertilizers. Some of the phenoxy acids, salts, and esters are moderately irritating to skin, eyes, and respiratory and gastrointestinal linings. In a few individuals, local depigmentation has apparently resulted from protracted dermal contact with phenoxy compounds. Although acute irritant contact dermatitis induced by herbicides is common, chemical burns induced by herbicides have been reported infrequently in the literature. Here we describe a chemical burn in a 25 year old female after sitting on a lawn that had been sprayed with MCPP 3 days earlier. This case illustrates potential hazards of the herbicide on the lawn of a public park. (Korean J Dermatol 2011;49(10):936∼939)

Systematic analysis of cDNA microarray-based CGH.

Park, Chan Hee,Jeong, Ha Jin,Choi, Yeon Ho,Kim, Sang Cheol,Jeong, Hei Chul,Park, Kyu Hyun,Lee, Gui Yeon,Kim, Tae Soo,Yang, Sang Wha,Ahn, Sung Whan,Kim, Yang Seok,Rha, Sun Young,Chung, Hyun Cheol UNKNOWN 2006 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.17 No.2

<P>cDNA microarray-based CGH (Microarray-CGH) is a useful technique for detecting genomic aberrations with a high resolution. However, the criteria for determining a genomic alteration have not been determined. We evaluated the genome-wide measurement of copy number of each gene in normal gastric and placenta tissues with both sex-matched, direct and sex-mismatched, indirect designs using 17K cDNA microarray. The results revealed the range of genomic copy number of normal tissues to be +/-0.3 of the log(2) ratio (gain >0.3, loss <-0.3) in the autosomal genes with direct and indirect designs. The copy number at a gene level from the X chromosomal genes using the direct and indirect sex-mismatched designs was +/-0.68 of the log(2) ratio (amplification >0.68, deletion <-0.68). In summary, the suggested method can be used as a guideline for analysis of genomic aberration using a Microarray-CGH in both direct and indirect designs.</P>

A Case of Hidradenoma Showing Eccrine & Apocrine Differentiation

Hei Sung Kim,Hyun Jeong Park,Chan Kum Park,Jun Young Lee,Baik Kee Cho 대한피부과학회 2005 Annals of Dermatology Vol.17 No.1

2상유동 이젝터의 유량비 및 승압 특성

양희천(Hei-Cheon Yang),설승규(Seung-Kyu Seol),성용록(Yong-Lok Sung),박현성(Hyun-Sung Park),박형권(Hyung-Kwon Park) 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.12

The optimum mixing tube length is recognized to give the maximum entrainment rate of suction fluid. Also, the diffuser ability with optimum design in a two-phase ejector to diffuse efficiently the high velocity mixture stream is of great importance to the overall momentum recovery of the ejector. The aim of this study is to investigate the mass ratio and lifting pressure characteristics with design parameters of two-phase ejector. The mixing tube length ratio and the area ratio of diffuser outlet to mixing tube are used to investigate the influence of geometry on the entrainment and pressure lifting characteristics. It was found that as the mixing tube length ratio increased or diffuser exit area ratio decreased the mass ratio and lifting pressure ratio increased and then decreased slightly or remained constant.

Recent Trend in the Incidence of Premalignant and Malignant Skin Lesions in Korea between 1991 and 2006

Kim, Hei Sung,Cho, Eun Ah,Bae, Jung Min,Yu, Dong Soo,Oh, Shin Taek,Kang, Hoon,Park, Chul Jong,Lee, Jeong Deuk,Lee, Jun Young,Kim, Si-Yong,Kim, Hyung Ok,Park, Young Min The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.6

<P>We evaluated the recent trend in the incidence of premalignant and malignant skin lesions between 1991 and 2006. Among 571,057 newly registered dermatology out-patients from our 8 affiliated university hospitals, 2,598 were diagnosed with a premalignant (899, 0.16%) or malignant skin lesions (1,699, 0.30%). Of 899 premalignant cases, 71.2% were actinic keratosis (AK), and 24.6% were Bowen's disease. Of 1,699 malignant cases, 46.2% were basal cell carcinoma, followed by squamous cell carcinoma (19.1%) and melanoma (7.1%). This 16-yr survey was divided equally into two time periods to compare the incidence of premalignant and malignant skin lesions at different time settings. Between 1991 and 1998, the incidence of cutaneous premalignancy was 0.10% which doubled during 1999-2006. For cutaneous malignancy, the incidence was 0.25% during 1991-1998 and 0.34% in 1999-2006. Incidence of AK among the new outpatients was 0.07% in 1991-1998 which staggered up to 0.15% in 1999-2006. These findings show an increase of both premalignant and malignant skin lesions, AK in particular in the dermatology outpatient-based incidence.</P>

패키지디자인에 있어서 색채 계획의 고찰

박희성(Hei-sung Park),이동연(Dong-yun Lee) 한국디자인학회 1998 디자인학연구 Vol.- No.27

Skin barrier function recovery after diamond microdermabrasion

KIM, Hei Sung,LIM, Sook Hee,SONG, Ji Youn,KIM, Mi-Yeon,LEE, Ji Ho,PARK, Jong Gap,KIM, Hyung Ok,PARK, Young Min Wiley (Blackwell Publishing) 2009 The Journal of Dermatology Vol.36 No.10

<P>Microdermabrasion is a popular method for facial rejuvenation and is performed worldwide. Despite its extensive usage, there are few publications on skin barrier change after microdermabrasion and none concerning diamond microdermabrasion. Our object was to see changes in transepidermal water loss (TEWL), hydration and erythema of the face following diamond microdermabrasion. Twenty-eight patients were included in this spilt face study. TEWL, stratum corneum hydration and the degree of erythema were measured from the right and left sides of the face (forehead and cheek) at baseline. One side of the face was treated with diamond microdermabrasion and the other side was left untreated. Measurements were taken right after the procedure and repeated at set time intervals. Diamond microdermabrasion was associated with a statistically significant increase in TEWL immediately after the procedure and at 24 h. However, on day 2, levels of TEWL were back to baseline. An increase in hydration and erythema was observed right after microdermabrasion, but both returned to baseline on day 1. The results show that skin barrier function of the forehead and cheek recovers within 2 days of diamond microdermabrasion. Diamond microdermabrasion performed on a weekly basis, as presently done, is expected to allow sufficient time for the damaged skin to recover its barrier function in most parts of the face.</P>

Three Cases of Verruca Plana Treated Successfully with 5% Imiquimod Cream

Hei Sung Kim,Hyun Jeong Park,Jun Young Lee,Baik Kee Cho 대한피부과학회 2005 Annals of Dermatology Vol.17 No.1