급성 심근 경색증과 혈장 Paraoxonase activity와의 관계

김건영,윤상준,박근호,조영신,장성종,장경식,홍순표 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

연구배경: 혈장 파라옥소나제의 감소는 HDL-cholesterol의 항 산화작용의 중요한 요소로 알려져 있어 이의 감소는 항산화작용의 저하로 인해 동맥경화의 진행을 촉진시킬 수 있어 허혈성심장병의 주요 위험인자로 추정하고 있다. 본 연구에서는 급성 심근 경색증 환자를 대상으로 혈장 파라옥소나제의 활성도를 측정하여 정상군과 비교하여 혈장 파라옥소나제 활성도의 감소가 급성 심근 경색증의 위험인자인지 알아보고자 하였다. 대상 및 방법: 급성 심근 경색증으로 입원한 39 명의 환자(남자 : 여자 = 19 : 20, 평균나이: 61±4.3세)와 정상 대조군 36명(남자 : 여자 = 17 : 19, 평균나이: 55±10세)을 대상으로 정맥혈을 채혈 후 파라옥소나제 활성도와 LDL-cholesterol, total cholesterol, HDL-cholesterol를 측정하였다. 두 군간의 비교는 Student T-test를 이용하였다. 결과: 건강 대조군과 급성 심근 경색 환자군 간에 측정치를 비교해본 결과 혈장 콜레스테롤 수치는 182.10± 12mg/dl, 194.87± 40mg/dl이고 HDL 콜레스테롤은 54±5.4mg/dl, 37.52± 13mg/dl 였다. LDL 콜레스테롤은 94.45±13mg/d1, 122±34mg/d1로 급성 심근 경색증 환자의 경우 통계학적으로 의미있는 차이를 보였다. (P<0.05). 그러나 혈장 파라옥소나제 활성도는 건강 대조군 112.35±15U/ml, 급성심근 경색증 환자군 96.10±43.50U/ml로 급성 심근 경색증 환자군이 건강 대조군에 비해 낮은 수치를 보이는 경향이 있었으나 통계학적으로 유의한 차이(P=0.071)는 보이지 않았다(Table 2참조). Background : Human plasma paraoxonase is a HDL-associated ester hydrolase that catalyzes the hydrolysis of organophosphates, aromatic carboxylic acid esters and carbamates. HDL has been implicated in the prevention of LDL lipid peroxidation. Low paraoxonase activity in the Plasma may have responsibility to the development of coronary artery disease partially because oxidized LDL has intimate relationship with atherosclerosis. We studied plasma paraoxonase activities in the plasma of acute myocardial infarction patients in order to evaluate the relationship between these enzyme activities and the acute myocardial infarction. Materials and Methods : plasma samples were obtained from 39 individuals with acute myocardial infarction(M: 19 cases, F: 20cases, mean age: 61(4.3 years) and 36 individuals of healthy control(M: 17 cases, F: 19cases, mean age: 55(10 years). We determined paraoxonase activities, total cholesterol, LDL-cholesterol &DL-cholesterol levels in the plasma samples. Paraoxonase activities were measured spectrophoto metrically in 0.1M Tris-HCl buffer (pH=7.4) at 25℃ with paraoxon as substrate(5.5mM) at 405 nm. We used student T-test to compare the results of both groups. Results : Comparison of the results between myocardial infarction patients and normal control groups revealed that plasma total cholesterol, HDL-cholesterol and LDL-cholesterol levels showed statistically significant differences between groups but plasma paraoxonase activity does not. Conclusion : Our study showed that there was no significant difference of plasma paraoxonase activity between acute myocardial infarction and normal population. So low plasma paraoxonase activity may not be a risk factor of acute myocardial infarction. but further prospective large scale study will be needed to conclude.

심한 하악골 전돌증 환자의 외과적 치험례

권대근,이상한,이근호,장도근 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

Obwegeser Ⅱ method and Rigid fixation conserving the condylar position has been performed on 5 patients with severe mandibular prognathism, and we obtained the result after the follow up study follows. 1. Obwegeser Ⅱ method is considered to move the distal segment passively when surgical correction of severe open bite correction and large amount of set back above 15mm is needed. 2. In one case that has more change of condylar position after operation, documented immediate post- operative relapse have been occurred 3. In the others that have adequate control of condylar position, passive set back and firm skeletal fixation, more functional and esthetic improvement and more post-operative stability has been achieved

측사위경두개방사선사진(Oblique Transcranial Radiograph)을 이용한 하악전돌증환자의 하악지 시상골절단술후 하악과두위치변화 분석

권대근,이상한,장현중 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.1

This study was intended to evaluate condyle position and the relationship of condyle position change and post surgical relapse following the sagittal split ramus osteotomy for mandible setback in 25 patients by paired t-test and multiple regression analysis. We used oblique transcranial and cephalometric radiographs taken before operation, immediate after operation, and at least 6 months post operatively. 1. In oblique transcranial view, posterior joint space was decreased immediate after operation and increased 6 months after operation. To compare the measurement before and 6 months after operation, there was no statistically significant change in over all joint spaces(P>0.05). 2. The joint spaces changed under the 0.2mm were 30%, 0.2mm to 1.0mm were 60.7%, above 1.0mm were 9.3%. This result reveals that condyle position was relatively reproduced to pre-operative state. 3. Statistically, the amount of mandible set back didn't influence the post operative relapse(P>0.05). 4. Statistically, the amount of mandible set back didn't influence the condylar displacement(P>0.05), and the amount of joint space change didn't influence the post operative relapse.(P>0.05) The changes in joint space is in the standard tracing error or within the adaptive capacity of the individual, it was too small to influence the stability of surgery.

Micrococcus sp. M1에 의한 Phenol과 ρ-Cresol의 생분해 Kinetics

송홍주,장웅석,이건,이상준 한국환경과학회 1997 한국환경과학회지 Vol.6 No.2

In order to find the most fitted biodegradation model, biodegradation kinetics model to the initial phenol and p-cresol concentrations were investigated and had been fitted by the linear regression. Bacteria capable of degrading p-cresol were isolated from soil by enrichment culture technique. Among them, strain M1 capable of degrading p-cresol has also degraded phenol and was identified as the genus Micrococcus from the results from of taxonomical studies. The optimal conditions for the biodegradation of phenol and pcresol by Micrococcus sp. M1 were NH_4NO_3 0.05%, pH 7.0, 30℃, respectively, and medium volume 100㎖/250㎖ shaking flask. Micrococcus sp. M1 was able to grow on phenol concentration up to 14mM and p-cresol concentration up to 8mM. With increasing substrate concentration, the lag period increased, but the maximum specific growth rates decreased. The yield coefficient decreased with increasing substrate concentration. The biodegradation kinetics of phenol and p-cresol were best described by Monod with growth model for every experimented concentration. In cultivation of mixed substrate, p-cresol was degraded first and phenol was second. This result implies that p-cresol and phenol was not degraded simultaneously.

Immunoturbidimetric assay를 이용한 철결핍 및 만성질환에 의한 빈형에서 가용성 트란스페린 수용체 측정의 진단적 유용성

박영진,박건,박상묵,최영화,장숙진,문대수 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background : Soluble transferrin receptor (sTfR) has been known to be a good marker for evaluating iron deficiency anemia (IDA) and anemia of chronic disease (ACD) without bone marrow aspiration. The sTfR has been measured with enzyme linked immunosorbent assay (ELISA). However, Immunoturbidimetric (IT) assay for measuring sTfR was recently introduced. Author try to use clinical application and measure sTfR using IT assay. Methods : IDA group (26 patients, ferritin < 12.0 μg/L), ACD group (20 patients, ferritin > 60.0 μg/L), Iron depletion and control group (30 normal persons) were classified. Hemoglobin, RBC indices, serum iron, serum transferrin, serum ferritin, total iron binding capacity were measured and calculated. Serum sTfR measured with IT assay using automated chemical analyzer. Those sTfR levels of each other group were compared. The correlations between iron parameters and sTfR were studied in other group. Results : The sTfR receptor levels were prominently higher in IDA group (5.2 ± 2.2 nmol/L) than in ACD group (1.1 ± 0.8 nmol/L), and normal control group (1.4 ± 0.3 nmol/L). The sTfR levels between ACD group and control group was not different. The correlations between sTfR and Hb levels in IDA group was in good inverse line. Other iron parameters and sTfR levels were not correlated in other groups. Conclusion : The results indicate that IDA can be differentiated efficiently from ACD with IT method to measure sTfR.

폐혈관상이 유지된 선천성 낭성 선종양 기형

배일헌,한기석,차상훈,김성진,박길선,이건국,홍장수 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

선천성 낭성 선종양 기형은 태생 16주 이후 말단세기관지의 형성이 중단되어 미성숙기관지들과 중배엽성분들이 과도하게 증식하여 발생하는 드문 선천성 폐질환이다. CT소견은 낭종의 크기 숫자, 내용물 등에 따라 다양하나, 병변내에 정상적인 폐혈관이 보인 예는 전세계적으로 보고된 적이 없었다. 저자들은 역동적 흉부 CT상 균일한 저음영의 병변내에 정상 폐혈관상이 유지된 선천성 낭성 선종양 기형 1예를 경험하였기에 보고한다. Congenital cystic adenomatoid malformation(CCAM) is a rare pulmonary disease that is thought to be developed by abnormal proliferation of immature alveoli and other mesenchymal component from the abrupt halting of the terminal alveoli formation after 16 weeks of gestation. On CT scan, there are no consistencies regarding to size, numbers, and its contents but no cases were reported in past showing normal pulmonary vascularities. We reports a case of CCAM that showed normal pulmonary vascularities within the hypodense lesions on a dynamic chest CT

Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer

Jang, Hee-Jin,Lee, Hyun-Sung,Burt, Bryan M,Lee, Geon Kook,Yoon, Kyong-Ah,Park, Yun-Yong,Sohn, Bo Hwa,Kim, Sang Bae,Kim, Moon Soo,Lee, Jong Mog,Joo, Jungnam,Kim, Sang Cheol,Yun, Ju Sik,Na, Kook Joo,Cho BMJ Publishing Group Ltd 2017 Gut Vol.66 No.2

<P>Conclusion We developed an easy-to-use prognostic model with three sncRNAs as robust prognostic markers for postoperative recurrence of ESCC. We anticipate that such a stratified and systematic, tumour-specific biological approach will potentially contribute to significant improvement in ESCC treatment.</P>

Analysis on the ratio of emergency department visits by elderly and non-elderly patients based on disease and particulate matter concentration in South Korea: a multicenter cross-sectional observational study

( Geon Hee Han ),( Suyeon Park ),( Youngjoo Lee ),( Hye Young Jang ),( Young Shin Cho ),( Heajin Chung ),( Sang-il Kim ),( Beom Sok Seo ),( Young Wha Sohn ),( Joonbum Park ) 대한응급의학회 2021 대한응급의학회지 Vol.32 No.6

Objective: Many previous studies have reported relationships between particulate matter < 10 μm (PM10) and asthma in emergency department (ED) settings, but few have examined its effect on cerebrovascular diseases. We evaluate the “Lag effect” between PM10 and asthma, chronic obstructive pulmonary disease (COPD), myocardial infarction (MI), and ischemic and hemorrhagic stroke among patients that visited an ED. Methods: This study was retrospectively conducted on 96,077 patients that visited one of the 137 EDs in Seoul, Incheon, and Gyeonggi Province in South Korea in 2017. Medical information and 10th revision International Classification of Disease codes were obtained from the National Emergency Department Information System and PM10 levels from AirKorea. We used Poisson regression analysis to evaluate the lag effects of PM10 on diseases of interest. “Lag day 0” was defined as the day when PM10 > 80 μg/㎥, and the PM10 values on the 5 following days were recorded. To assess the cumulative effects of PM10, we calculated relative risk (RR) by analyzing the cumulative effects over 6 days (lag days 0 to 5). Results: Asthma, COPD, and ischemic stroke patients (< 65 years old) showed a positive correlation between PM10 (asthma on lag day 5: RR, 2.587; 95% confidence interval [CI], 2.001-3.344; COPD on lag day 4: RR, 3.727; 95% CI, 2.988-4.650; and ischemic stroke on lag day 4: RR, 1.573; 95% CI, 1.168-2.118). MI in those≥65 showed the highest RR on lag day 1 (RR, 1.471; 95% CI, 1.042-2.077). Hemorrhagic stroke was not found to be significantly correlated with PM10 in either age group. Conclusion: An increase in PM10 is associated with ED visits by patients<65 years old with asthma, COPD, or ischemic stroke, and with MI for those≥65 years.

Evaluation of QuickGene DNA Tissue Kit S for Extraction of Hepatitis B virus DNA from Serum

Geon Park · Sung Sik Cho · Dae Soo Moon · Young Jin Park · Sook Jin Jang 조선대학교 의학연구원 2009 The Medical Journal of Chosun University Vol.34 No.4

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A Study on the Border of the Wetland through a Vegetation Survey of Cheonnae Marsh

Jang Hee Cheol,Kim Young Bin,Kim Jae Hun,Son Geon Ju,Yoon Ki Sang 한국환경교육학회 2015 한국환경교육학회 학술대회 자료집 Vol.2015 No.12