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랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구
김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.
Matti-Russe술식을 이용한 주상골 불유합의 치료
안상로,정진선,박원,우영길 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
13 Cases of scaphoid nonunion had been treated by original Matti-Russe procedure and followed up more than 2 years, from September 1990 to September 1993, at the Department of Orthopedic Surgery, Chung Nam National University Hospital. The results were as follows ; 1. Scaphoid nonunion occurs between 21 to 40 years of age( 13 cases ) and 13 cases were all male. 2. Most commonly, the site of fracture were confined to middle one third in 9 cases( 69 %), and fracture line were transverse in 6 cases( 46% ). 3. Radiological union was obtained with DISI deformity correction and normalization of intrascaphoid angle in all cases. 4. The result of treatment were excellent in 8 cases( 61%), good in 4 cases( 31%) and fair in 1 case( 8%)
Mg 其他 複合材料의 强化材 量 및 分布에 따른 機械的性質特性
안선규,하홍수,김영직,임병수 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.1
The effect of different SiC particle size and weight fraction in Mg/SiC particle MMC on the mechanical properties has been investigated. In this study, different particle sizes of 7㎛, 20㎛ and 50㎛ were prepared with various weight fraction of 10wt.%, 20wt.% and 30wt.% for sample preparation. By tension tests, the properties of ultimate tensile stress, yield stress and % elongation were observed and by tension-tension fatigue tests, whose procedures are standardized in ASTM standard 647E-93, the ΔK vs, da/dN curves were also obtained. Finally, the crack propagation paths were observed by optical microscope.
안정기,이기천,허승식,이종선,정현용,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1
Nizatidine is a newly introduced potent H2-receptor antagonist of acid secretion with long duration of action. For evaluation of clinical efficancy and safety, twenty one patients with endoscopically proved thirteen gastric ulcers and eight duodenal ulcers were treated with nizatidine 300mg at bed time via per os for 6 weeks. The results were as follows 1. The rate of complete endoscopic healing of duodenal ulcer 92.3% and 87.5% after 6 weeks. The overall healing rate of peptic ulcer was achieved in 89.9% at 6 weeks. 2. Clinical symptoms disappeared in 84.6%, 92.3% and 100% of patients with duodenal ulcer and 75.0%, 87.5% and 87.5% patients with gastric ulcer at 2, 4 and 6 weeks respectively. 3. There were not developed any symptoms and signs suggesting side effect of drug. In conclusion, data from this study suggest that nizatidine 300mg p.o. at sleeping time is effective and safe in treatment of peptic ulcer disease, and is well tolerated on a short-term basis.
安鍾弼,朴吉鉉,金永先 조선대학교 국토개발연구소 1988 국토개발연구 Vol.8 No.1
In Seadyke design a surface stress Calculation using osterberg chart for few point has been generally used to settlement quantity Computation. This study is developed to the Computer Program of integral formula having a Zonal triangular load, A few Case studies are examinedand find out degree of error about the Cross section. This results can be use to the seadyke design.
안현숙,최선영,고광준 대한구강악안면방사선학회 2001 Imaging Science in Dentistry Vol.31 No.2
Inflammatory pseudotumor was originally described in the lung , but recently has been recognized to occur in various sites. A 56-year-old female was referred to our department with a painless swelling of the right midfacial area since 3 months ago. Clinical examination showed non-specific intraoral findings, but asymmetric facial appearance and numbness of the right midfacial area. Plain radiographs and CT images showed aggressive destruction and irregular thickening of the right maxillary sinus wall, increased antral opacification, and destruction of the zygomatic arch. A relatively well-defined soft tissue mass occupied the right maxillary sinus, nasal cavity, zygoma, and infraorbital region. The soft tissue mass showed mild enhancement on CT. Radiographically, this lesion presented a rapidly enlarging mass demonstrating aggressive behavior, mimicking a malignant tumor. Histopathologic examinations showed plasma cells and inflammatory cells in variable fibrotic tissues and demonstrated positive reactivity for vimentin. No malignent changes could be found (Korean J Oral Maxillofac Radiol 2001;31:121-7)