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Sulaiman F. A.,Iyiola O. A.,Anifowoshe T. A.,Sulaiman A. A.,Bello O. K.,Akinyele T. J.,Jimoh A. M.,Maimako R. F.,Otohinoyi D. A.,Osemwegie O. O.,Adeyemi O. S. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.1
The Trypanosoma brucei is the causative agent of African trypanosomiasis, a disease that affects both humans and animals. Chemotherapy which forms the major means of control for the disease has several shortcomings such as limited efficacy and adverse side effects amongst others. Thus, motivating the search for better therapies. In this study, extracts of some tropical plants including the Acacia nilotica, Bombax buonopozense and Khaya senegalensis were evaluated for therapeutic and prophylactic potential in mouse model of experimental trypanosomiasis. Both diminazene aceturate and isometamidium chloride were included as reference drugs. Results showed that T. brucei caused an elevation in rat plasma indirect bilirubin and a reduction in rat plasma albumin and total protein which suggest mild hepatic dysfunction due to experimental infection. Data also revealed that the plant extracts significantly reduced the rat parasite burden both in the prophylaxis and therapeutic treatment groups when compared with the negative drug control. The infection and treatments had no adverse effect on the rat organ and body weights. The infection did not alter the activity of rat plasma ALT, AST and ALP compared with the administered extracts of A. nilotica and B. buonopozense. Further, the plant extracts ameliorated some trypanosomiasisinduced pathologies in treated rats compared with negative drug control. Taken together, findings do not only lend credence to the folkloric use of these plants for medicinal purposes but also suggest these plant extracts have potential to serve as alternative source of anti-parasitic agents particularly for the control of trypanosomiasis
Sulaiman, Rania S.,Park, Bomina,Sheik Pran Babu, Sardar Pasha,Si, Yubing,Kharwadkar, Rakshin,Mitter, Sayak K.,Lee, Bit,Sun, Wei,Qi, Xiaoping,Boulton, Michael E.,Meroueh, Samy O.,Fei, Xiang,Seo, Seung- American Chemical Society 2018 ACS CHEMICAL BIOLOGY Vol.13 No.1
<P>The standard-of-care therapeutics for the treatment of ocular neovascular diseases like wet age-related macular degeneration (AMD) are biologics targeting vascular endothelial growth factor signaling. There are currently no FDA approved small molecules for treating these blinding eye diseases. Therefore, therapeutic agents with novel mechanisms are critical to complement or combine with existing approaches. Here, we identified soluble epoxide hydrolase (sEH), a key enzyme for epoxy fatty acid metabolism, as a target of an antiangiogenic homoisoflavonoid, SH-11037. SH-11037 inhibits sEH <I>in vitro</I> and <I>in vivo</I> and docks to the substrate binding cleft in the sEH hydrolase domain. sEH levels and activity are up-regulated in the eyes of a choroidal neovascularization (CNV) mouse model. sEH is overexpressed in human wet AMD eyes, suggesting that sEH is relevant to neovascularization. Known sEH inhibitors delivered intraocularly suppressed CNV. Thus, by dissecting a bioactive compound’s mechanism, we identified a new chemotype for sEH inhibition and characterized sEH as a target for blocking the CNV that underlies wet AMD.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/acbcct/2018/acbcct.2018.13.issue-1/acschembio.7b00854/production/images/medium/cb-2017-00854f_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cb7b00854'>ACS Electronic Supporting Info</A></P>
Impact of Facebook Usage on Firm’s Performances among Malaysian Chinese Retailers
Sulaiman Sajilan,Shehnaz Tehseen,Eiad Yafi,Xiong Ting 사람과세계경영학회 2019 Global Business and Finance Review Vol.24 No.4
Social media including Facebook has been acknowledged to play a vital role in firms achieving superior performance. Malaysia is a multicultural country in which the Malaysian Chinese are considered to be the most successful entrepreneurs. There is, however, a lack of research regarding the influence of Facebook usage on firm performance among Malaysian Chinese retailers. As such, this study had two aims. Firstly, the study investigated the influence of compatibility, cost effectiveness, trust, and interactivity on Facebook usage among Malaysian Chinese retailers. Secondly, the study assessed the impact of these retailers’ Facebook usage on their perceived financial performance, perceived non-financial performance, perceived business growth, and perceived performance relative to competitors under the moderating impact of market turbulence. This study developed a conceptual model based on the Strategic Contingency Theory (SCT) and Diffusion of Innovation (DOI) theory, and used a structured survey instrument to gather data. Using non-probability sampling techniques, 129 Malaysian Chinese retailers from Kuala Lumpur and Selangor were recruited for the study. Data was analysed using PLS-SEM techniques. The results showed that only compatibility, cost effectiveness, and interactivity have a statistically significant positive influence on Facebook usage, which in turn has a statistically significant positive influence on the retailers’ perceived financial performance, perceived non-financial performance, perceived business growth, and perceived performance relative to competitors. Moreover, market turbulence was only found to be a moderator that improves the impact of Facebook usage on perceived financial performance, perceived business growth, and perceived performance relative to competitors, but not perceived non-financial performance. These findings contribute to current literature and provide insights into the role and importance of Facebook usage on firm performance among Malaysian Chinese retailers, possibly encouraging more retailers to deploy social media in their business processes.
Current status, challenges, and future prospects of plant genome editing in China
Sulaiman Ahmed,Yandi Zhang,Muhammad Abdullah,Qiuxiang Ma,Hongxia Wang,Peng Zhang 한국식물생명공학회 2019 Plant biotechnology reports Vol.13 No.5
Genome editing (GE) is the most powerful tool for creating genetic variation in plants. This approach is valuable for studying the mechanism of gene function and regulation as well as to improve desirable traits using sequence-specific endonucleases. It is typically performed with diverse molecular scissors that cleave a particular gene at a defined position. The advent of sequence-specific nucleases such as ZFNs (zinc finger nucleases), TALENs (transcription activator-like effector nucleases), and CRISPR (clustered regularly interspaced short palindromic repeats), in particular, have allowed for the precise and efficient introduction of genetic variation into the genome. The newly developed CRISPR-associated protein 9 (Cas9) variants, base-editing systems, novel RNA-directed nucleases, and DNA-free CRISPR/Cas9 delivery methods offer great opportunities for plant genome engineering. China has made tremendous progress in the field of GE for crop improvement to meet the demand of growing population. Herein, we reviewed the recent progress in GE of different crops in China, highlighting advanced GE tools/methods, and also discussed the specific challenges and prospects of plant GE.
INTEGRAL INEQUALITY REGARDING γ-CONVEX AND γ-CONCAVE FUNCTIONS
Sulaiman, WaadAllah T. Korean Mathematical Society 2010 대한수학회지 Vol.47 No.2
New integral inequalities concerning $\gamma$-convex and $\gamma$-concave functions are presented.
Effect of low levels of hydrotropes on micellization of phenothiazine drug
Sulaiman Y. M. Alfaifi,Dileep Kumar,Malik Abdul Rub,Farah Khan,Naved Azum,Anish Khan,Abdullah M. Asiri,Hurija Džudžević-Čančar 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.2
Interactions within mixtures of the phenothiazine drug promethazine hydrochloride (PMH) and cationic hydrotropes ortho-toluidine hydrochloride (o-TDH) and para-toluidine hydrochloride (p-TDH) were investigated at different ratios and temperatures via conductometry to understand various physicochemical properties. Critical micelle concentration (cmc) was less than values of cmcid (cmc in ideal mixed system), indicating significant interaction among the studied constituents in solution mixtures. The cmc of pure PMH was also determined by measuring the surface tension for comparison. A variety of micellization thermodynamic parameters (Gibbs free energy [Gm 0 ], change in standard enthalpy [Hm 0 ], and change in entropy [Sm 0 ]) were computed using conductometry. The micellar mole fraction (X1 Rb, X1 Rod, and X1 id) of hydrotropes estimated by various theoretical models (Rubingh, Rodenas, and Motomura) was assessed, and the results showed a greater contribution of hydrotropes in mixed micelles along with their values increasing via an increase in mole fraction (1) of hydrotropes (o-TDH/p-TDH). Negative values suggest extremely favorable attractive interaction/synergism, as declines occurred in the whole quantity of amphiphile used for the desired purpose, leading to a drop of expenditure along with ecological concern. Obtained activity coefficients (f1 and f2) were always beneath unity, meaning nonideality was found between PMH and o-TDH/p-TDH. Like the conductivity method, the UV-visible and FT-IR techniques also demonstrate the interaction between the PMH and o-TDH/p-TDH.