RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제
      • 좁혀본 항목 보기순서

        • 원문유무
        • 원문제공처
          펼치기
        • 등재정보
        • 학술지명
          펼치기
        • 주제분류
        • 발행연도
          펼치기
        • 작성언어

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI등재

        Relationship between Clozapine-Induced Electroencephalogram Abnormalities and Serum Concentration of Clozapine in Japanese Patients with Treatment-Resistant Schizophrenia

        Yuka Sugawara Kikuchi,Takashi Kanbayashi,Tetsuo Shimizu 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.4

        ObjectiveaaThe objective of this study was to investigate the relationship between the serum concentration of clozapine (C-CLZ), Ndesmethylclozapine (N-CLZ) and the daily dose of CLZ (D-CLZ), and the relationships among CLZ and electroencephalogram (EEG) abnormalities. MethodsaaTwenty-eight patients were recruited to this study, but 8 patients were excluded because clozapine was discontinued before the post-treatment measurement of EEG or C-CLZ. Ultimately, 20 patients (6 men, 14 women) with an average age of 36 years were enrolled. The subjects were divided into EEG normal and abnormal groups. C-CLZ and N-CLZ were measured at 4, 12, 26, and 52 weeks after initiating CLZ administration. ResultsaaAll patients had normal baseline EEG signals, and 8 patients showed EEG abnormalities later. There were significant correlations between C-CLZ and D-CLZ, and between N-CLZ and D-CLZ. The C-CLZ/D-CLZ, N-CLZ/D-CLZ, and C-CLZ/N-CLZ ratio were not significantly different between the EEG normal and EEG abnormal groups. The EEG abnormal group had significant higher proportion of patients with high intra-individual variability in their C-CLZ/D-CLZ ratio. ConclusionaaThere is no relationship between C-CLZ and EEG abnormalities. However, patients with high intra-individual variability in their C-CLZ/D-CLZ ratio had greater possibility of exhibiting EEG abnormalities.

      • KCI등재

        Evaluation of CD4+ cells infiltration as a prognostic factor in cervical intraepithelial neoplasia 2

        Guanliang Chen,Takashi Iwata,Masaki Sugawara,Hiroshi Nishio,Yuki Katoh,Iwao Kukimoto,Daisuke Aoki 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.1

        Objective: To identify candidate predictors for the prognosis of cervical intraepithelial neoplasia 2 (CIN2) lesions and evaluate the prognostic value of the local immune response. Methods: One hundred fifteen CIN2 patients were enrolled. The percentage of p16-, minichromosome maintenance complex component 2- or apolipoprotein B mRNA editing enzyme catalytic subunit 3G (APOBEC3G)-positive cells was determined immunohistochemically. Tumor-infiltrating lymphocytes (TILs) in intertumoral lesions were scored using an automated system. CIN3 disease progression and regression rates were estimated by the Kaplan–Meier method. A case-control study was conducted to screen CIN2 prognostic factors in 10 regression and 10 progression patients. Selected factors were examined in a cohort study to determine their prognostic value for CIN2. Results: Among all participants, the cumulative progression and regression rates at 60 months were 0.477 and 0.510, respectively. In the case-control study, p16- and APOBEC3G-positive cells were higher in the progression group (p=0.043, p=0.023). Additionally, CD4+ cell infiltration was enhanced in the regression group (p=0.023). The cohort study revealed a significantly increased progression rate in patients with elevated p16-positive cells (p<0.001), and increased CD4+ TIL infiltration was associated with better regression (p=0.011). Kaplan–Meier analysis according to human papillomavirus (HPV) positivity revealed a greater CIN3 development risk in HPV16-positive patients than in HPV16-negative cases. Finally, multivariate analysis identified HPV16 infection and CD4+ TIL infiltration as independent prognostic factors in CIN2 regression. Conclusion: CD4+ TIL infiltration in intertumoral lesions was related with CIN2 regression. Our findings suggest CD4+ TIL infiltration may be useful for the triage of CIN2 patients.

      • 실제 환경을 고려한 다공질 콘크리트의 내동해성(耐凍害性) 평가

        중촌척낭 ( Takuro Nakamura ),굴구경 ( Takashi Horiguchi ),지촌화기 ( Shimura Kazunori ),관원융 ( Takashi Sugawara ) 한국건축시공학회 2008 한국건축시공학회 학술발표대회 논문집 Vol.8 No.2

        콘크리트는 연속공극률이 20%에서30%인 특수한 콘크리트이다. 토목공학 분야에서는, 포장재료1)로써는 배수ㆍ투수(透水)기능, 흡음(吸音)기능, 소음감소가 기대되며, 하천 호안( 둑보강)재료2,3)로써는 자연ㆍ생태계 보전, 경관 향상효과가 기대된다. 또한 건축공학 분야에서는 옥상 녹화를 비롯하여 도시의 열섬(heat island)현상의 완화 목적으로도 연구되고 있어, 고도화ㆍ다양화되는 사회자본 정비에 대해, 이와 같은 연속공극의 다기능성 재료의 다공질 콘크리트에 대해 많은 기대를 하고 있다. 다공질 콘크리트는 이와 같은 성능으로 인해, 물가에서의 이용가치가 높고, 한랭지에서 동해(凍害, 동결로 인한 피해)가 염려된다. 하지만 다공질 콘크리트의 내동해성을 평가하는 시험방법, 평가기준이 명확하지 않다. 기존 연구에 따르면, 공극 사이에 가득 차 있는 물이 빙결되는 환경 하에서는, 다공질 콘크리트에 대한 내동해성 평가가 낮지만5),그 이외의 경우에는 비교적 내동해성이 높아질 수 있다고 하며,동결융해 시험의 차이에 따라 평가가 다르게 보고되고 있다. 다공질 콘크리트의 내동해성(耐凍害性)평가에는 주로 재료, 공극률 등에 따른 영향을, 한 가지 동결융해시험방법에 의한 상대평가로 검토하는 연구가 많고, 동일한 배합 시의 복수의 동결융해시험을 실시한 연구는 적다. 본 연구에서는 다공질 콘크리트의 내동해성(耐凍害性) 평가를 목적으로,다공질 콘크리트가 시공되는 환경을 고려하여 4종류의 동결융해시험을 실시하였다. 4종류의 동결융해시험에는, 일본국내에서 폭넓게 채택되고 있는JIS A11488) A법(수중동결 수중융해)/B법(공기중동결 수중융해)및RILEM제안의 CIF9)/CDF10)법을 채용하였다. RILEM제안의 동결융해시험방법은 열역학적인 관점에서 고안된 것으로,지금까지의 동결융해시험의 상대동탄성 계수 변화에서 나아가, 스케일링양, 흡수량 측정을 포함하여, 실제 환경과의 대응, 재현성(再現成) 높이, 실험정밀도 등으로 콘크리트의 내동해성을 더욱 상세하게 검토할 수 있을 것으로 기대되는 시험방법이다11). 본 연구를 통해 얻은 성과를 정리해 보도록 하겠다. (6) JIS A법과 같이, 공극이 강제적으로 물이 가득 차게 되어 얼음이 형성되는 환경에서는 상대동탄성 계수 저하가 현저하며, 커다란 균열과 함께 붕괴하는 것을 확인하였다. 이런 환경에서는 AE콘크리트에 비해 내동해성이 낮으므로 시공할 때 이를 고려할 필요가 있다. (7) JIS B법 및 RILEM CIF/CDF법과 같이, 동결 시에 공극내에서 얼음이 형성되지 않는 환경에서는 내동해성 평가가 크게 향상되고, 특히 RILEM CIF/CDF법에서는 상대 동탄성 계수의 저하는 확인되지 않았다. (8) JIS A/B법에서, 다공질 콘크리트의 내동해성은 세골재를 혼합하거나, 굵은골재의 치수를 낮게 하는 등, 배합을 조정함으로써 개선이 가능한 것으로 확인되었다. (9) JIS B법과 RILEM CIF법의 결과, 다공질 콘크리트에서도 동결속도나 동결융해 사이클 수가 상대동탄성 계수 저하에 영향을 주며, paste막 두께가 얇은 다공질 콘크리트는 일반 콘크리트에 비해 그 영향도 큰 것으로 생각된다. (10) RILEM CIF/CDF시험 결과, 일반 콘크리트에서는 염분환경에서 스케일링에 의한 표면열화가 격렬해지지만, 다공질 콘크리트에서는 현저한 열화가 보이지 않으며, 염분공급 하에서의 표면열화에 비해 높은 내동해성을 유지하는 것을 확인하였다. Porous concrete has large continuous voids of 20.30 % by volume, and this concrete is attractive as environmental material in Japan i.e. permeable road pavement, river bank protection with vegetation and green roof system which influence thermal environment. It is necessary to confirm the frost resistance when constructing porous concrete structure in cold region. However applicable test method and evaluation criterion of porous concrete has not defined yet. Therefore, the object of this study is to investigate the frost resistance of porous concrete and this investigation attempts to address this concern by comparing 4 kinds of specified freezing and thawing tests methods (JIS A1148 procedure A/B and RILEM CIF/CDF test) in consideration of actual environment. RILEM freeze.thaw tests are different from JIS A1148 freeze.thaw tests, which are widely adopted for evaluating the frost resistance of conventional concrete in Japan, in water absorption, cooling rate, length of freezing and thawing period, and number of freezing and thawing cycles. RILEM CIF test measures internal damage and is primarily applicable for pure frost attack. CDF test is appropriate for freeze.thaw and de.icing salt attack. JIS A1148 procedure A/B showed extremely low frost resistance of porous concrete if the large continuous voids were filled with water and the ice expansion in the large continuous voids set in during cooling. Frost resistance of porous concrete was improved by mixing coarse aggregate (G7) which particle size is smaller and fine aggregate in JIS freezing and thawing tests. RILEM CIF/CDF test showed that freeze.thaw and de.icing resistance of porous concrete was seems to be superior in that of conventional concrete.

      • A New Approach of Imaging Defects in Concrete Structures

        Lee, Sanghun,Endo, Takao,Kagaya, Makoto,Sugawara, Takashi 한국방재학회 2012 한국방재학회 학술발표대회논문집 Vol.11 No.-

        Image created by stack imaging spectral amplitudes based on the impact-echo (SIBIE) method is largely one-dimensional because a single frequency domain spectrum for wave reflected below a single point of impact is used to create the image. The method has limitations for representing defects in a cross section of a concrete structural element using two-dimensional coordinates. This study focused on defect detection and visualization in a concrete structural element using multiple impacts and accumulated SIBIE. An impactor was used to induce energy at multiple points at positioned at prescribed intervals along the structural element. A modified SIBIE method was applied to the collected data of each point and the modified SIBIE images were accumulated to generate one image (an accumulated SIBIE image). As a result, the defect positions could be represented in the cross section of the structural element using a two-dimensional coordinate system.

      • KCI등재

        Sb NQR Study of the Filled Skutterudite CeFe4Sb12 Synthesized under High Pressure

        Ko-ichi Magishi,,Masahiro Takahashi,Takahito Saito,Kuniyuki Koyama,Hitoshi Sugawara,Takashi Saito,Sho Tatsuoka,Kenya Tanaka,Hideyuki Sato 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3

        We report the results of Sb nuclear quadrupole resonance (NQR) measurements on the filledskutterudite CeFe4Sb12 synthesized under high pressure (HP) and compare them with those forthe sample synthesized under ambient pressure (AP) to understand the influence of the Ce-sitefilling fraction. The NQR spectra for the HP sample are much sharper than those for the APsample, suggesting that the Ce filling fraction is higher. Also, the nuclear spin-lattice relaxationrate 1/T1 follows an exponential decrease 1/T1 ∝ exp(−Δ/kBT), with the gap being Δ/kB = 270K at temperatures above 100 K, which is larger than that for the AP sample. This result suggeststhat the c-f hybridization is enhanced by increasing the Ce-site filling fraction.

      • KCI등재

        Hot Carrier Effect in Low-Temperature Poly-Si TFTs with Sputtered Gate SiO2 Films

        Yukiharu Uraoka,Hiroshi Yano,Makoto Miyashita,Tadashi Serikawa,Takashi Fuyuki,Tomoaki Hatayama,Yuta Sugawara 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.4

        We investigated the reliability of low-temperature poly-Si thin film transistor (TFT) by using Si films and gate oxides fabricated by using RF sputtering method. To evaluate the immunity against the hot carrier effect, we imposed DC and dynamic stress on the sputtered TFT. We found that reliability was higher than it was a conventional TFT. The sputtered TFT showed very little degradation. Observation by emission microscope was performed to analyze their strong immunity. In a conventional TFT, emission was observed only at the drain edge. However, in sputtered TFT, emission was observed not only at the drain edge but also at the source edge. We proposed a model explaining the emission in a sputtered TFT. To prove this model, we examined the emission in a SOI TFT. A similar emission mode supports our model. Sputtered TFTs are very promising for next generation.?

      • 콘크리트 구조물의 결함탐사에 대한 새로운 가시화 수법

        이상훈,엔도타카오,카가야마코토,스가와라타케시,Lee. Sanghun,Endo. Takao,Kagaya. Makoto,Sugawara. Takashi 한국방재학회 2013 한국방재학회 학술발표대회논문집 Vol.2013 No.1

        Image created by stack imaging spectral amplitudes based on the impact-echo (SIBIE) method is largely one-dimensional because a single frequency domain spectrum for wave reflected below a single point of impact is used to create the image. The method has limitations for representing defects in a cross section of a concrete structural element using two-dimensional coordinates. This study focused on defect detection and visualization in a concrete structural element using multiple impacts and accumulated SIBIE. An impactor was used to induce energy at multiple points at positioned at prescribed intervals along the structural element. A modified SIBIE method was applied to the collected data of each point and the modified SIBIE images were accumulated to generate one image (an accumulated SIBIE image). As a result, the defect positions could be represented in the cross section of the structural element using a two-dimensional coordinate system.

      연관 검색어 추천

      이 검색어로 많이 본 자료

      활용도 높은 자료

      해외이동버튼