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RISS 인기검색어
- 검색키워드
- 저자 : Subrata Mallick (검색결과 2 건)
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Hemang Kansagra,Subrata Mallick 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.1
Luliconazole (LZ), a poorly water soluble synthetic imidazole derivative is used in the treatment of fungal infections of skin. Hence, the investigation was aimed at formulating microemulsion based gels (MBGs) for solubilization of LZ as well as its better penetration for efficacious anti-fungal treatment. The solubility of LZ in various oils was investigated. Out of tried oils, olive oil exhibited highest solubility. Suitable combination of surfactants and co-surfactants were screened for selected oil to yield O/W type microemulsion. The Pseudoternary phase diagrams were developed to determine microemulsion existence area. The developed microemulsion was evaluated for particle size analysis, isotropicity, pH, drug content and rheology. Drug loaded microemulsion was slowly added to the viscous solution of 1 % Carbomer 934 under magnetic stirring to prepare MBG. The prepared MBG were evaluated in terms of their droplet size, spreadability, stability, in vitro permeation studies, and rheological properties. The phase study revealed that the maximum proportion of oil was incorporated in microemulsion systems when the surfactant-to-cosurfactant ratio was 3:1. The microemulsion was optimized with its components of Olive oil as oil, Capmul MCM as a surfactant and iso propyl alcohol as a cosurfactant. The globule size of the optimized batch was 32.59 nm. The MBG was non-irritant indicating their safety and was active against C. albicans indicating its efficacy. Short term stability study performed as per ICH guideline exhibited stable characteristic of developed formulation. Therefore, MBG of LZ is an efficacious treatment for fungal infections.
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Development of standardization parameters of crude drugs used in Ayurvedic Balarista formulation
Chandan Das,Anindya Bose,Subrata Mallick,Debajyoti Das 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.4
‘Balarista’ is an important Ayurvedic arista formulation containing twelve crude drugs among which Sida cordifolia and Withania somnifera are the two major drugs. The Ayurvedic Formulary of India mentions various usages of Balarista, but it is mainly used in the treatment of rheumatoid arthritis. This study deals with the evaluation of pharmacognostic and physico-chemical properties of all incorporated drugs along with the HPLC and GC–MS analysis of the two main drugs. The macroscopic, microscopic, powder microscopy and physico-chemical parameters of diferent drugs were assessed according to the Ayurvedic Pharmacopoea of India. The scanning electron microscopic study, fuorescence analysis and powder behavior studies of various drugs in powder form were also carried out. The quantifcation of vasicine and total withanolides were analyzed in chloroform extract of Sida cordifolia and Withania somnifera root by HPLC method. Further, presences of other phytoconstituents were also confrmed by GC–MS analysis. The macroscopical, organoleptic, histological, powder characteristics and scanning electron microscopic images of various drugs revealed the important diagnostic features. The physico-chemical, fuorescence analysis and powder behavior characteristics provided useful tools to diferentiate them from the adulterants. The HPLC analysis detected percentage of vasicine and total withanolide (withanoside IV, withanoside V, withaferin A, 12-Deoxy withastramonolide, withanolide A and withanolide B) in Sida cordifolia and Withania somnifera root respectively. GC–MS analysis identifed ffty bioactive compounds in both the drugs. The pharmacognostical, physicochemical and chromatographic assessment of these medicinally important plant drugs could be helpful for their authentication and in ensuring the quality of Balarista formulation.
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