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        Ototoxicity: A Challenge in Diagnosis and Treatment

        Purushothaman Ganesan,Jason Schmiedge,Vinaya Manchaiah,Simham Swapna,Subhashini Dhandayutham,Purushothaman Pavanjur Kothandaraman 대한청각학회 2018 Journal of Audiology & Otology Vol.22 No.2

        Ototoxicity is the pharmacological adverse reaction affecting the inner ear or auditory nerve,characterized by cochlear or vestibular dysfunction. The panorama of drug-induced hearingloss has widened over last few decades. Although ototoxic medications play an imperativerole in modern medicine, they have the capacity to cause harm and lead to significant morbidity. Evidence has shown early detection of toxicity through prospective ototoxicity monitoringallows for consideration of treatment modifications to minimize or prevent permanenthearing loss and balance impairment. Although many ototoxicity monitoring protocols exist,their practicality is questionable due to several factors. Even though the existing protocolshave proven to be effective, certain lacunae in practice have been encountered due to discrepanciesamong recommended protocols. Implementation of these protocols is mostlyheld back due to the incapacitated status of the patient. The choice of early ototoxicity identificationtechniques is still debatable due to variables such as high degree of sensitivity,specificity and reliability, less time consumption and less labour-intensive to the patient. Hence, the diagnosis and effective treatment of ototoxicity is challenging, even today. A stringentprotocol with more practicality encompassing all elements aimed at profiling the effectsof ototoxicity is greatly needed. This review describes an efficient application of ototoxicitymonitoring and treatment protocol as an attempt to reduce the challenges in diagnosis andmanagement of ototoxicity.

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