http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Steffen Hofmann (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
A Wearable Real-time Activity Tracker
Ulf Jensen,Heike Leutheuser,Steffen Hofmann,Benno Schuepferling,Gerald Suttner,Kristin Seiler,Johannes Kornhuber,Bjoern M. Eskofier 대한의용생체공학회 2015 Biomedical Engineering Letters (BMEL) Vol.5 No.2
Purpose Exercise and physical activity is a driving force for mental health. Major challenges in the treatment of psychological diseases are accurate activity profiles and the adherence to exercise intervention programs. We present the development and validation of CHRONACT, a wearable realtime activity tracker based on inertial sensor data to support mental health. Methods CHRONACT comprised a Human Activity Recognition (HAR) algorithm that determined activity levels based on their Metabolic Equivalent of Task (MET) with sensors on ankle and wrist. Special emphasis was put on wearability, real-time data analysis and runtime to be able to use the system as augmented feedback device. For the development, data of 47 healthy subjects performing clinical intervention program activities were collected to train different classification models. The most suitable model according to the accuracy and processing power tradeoff was selected for an embedded implementation on CHRONACT. Results A validation trial (six subjects, 6 h of data) showed the accuracy of the system with a classification rate of 85.6%. The main source of error was identified in acyclic activities that contained activity bouts of neighboring classes. The runtime of the system was more than 7 days and continuous result logging was available for 39 h. Conclusions In future applications, the CHRONACT system can be used to create accurate and unobtrusive patient activity profiles. Furthermore, the system is ready to assess the effects of individual augmented feedback for exercise adherence.
-
Gerrit Wolters-Eisfeld,Baris Mercanoglu,Bianca T. Hofmann,Thomas Wolpers,Claudia Schnabel,Sönke Harder,Pascal Steffen,Kai Bachmann,Babett Steglich,Jörg Schrader,Nicola Gagliani,Hartmut Schlüter,Cenap 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of O-linked glycosylation of proteins. Here, we show that ablation of Cosmc in the exocrine pancreas of mice causes expression of truncated O-glycans (Tn antigen), resulting in exocrine pancreatic insufficiency with decreased activities of digestive enzymes and diabetes. To understand the molecular causes of the pleiotropic phenotype, we used Vicia villosa agglutinin to enrich Tn antigen-modified proteins from Cosmc-KO pancreatic lysates and performed a proteomic analysis. Interestingly, a variety of proteins were identified, of which bile salt-activated lipase (also denoted carboxyl-ester lipase, Cel) was the most abundant. In humans, frameshift mutations in CEL cause maturity-onset diabetes of the young type 8 (MODY8), a monogenic syndrome of diabetes and pancreatic exocrine dysfunction. Here, we provide data suggesting that differentially Oglycosylated Cel could negatively affect beta cell function. Taken together, our findings demonstrate the importance of correct O-glycan formation for normal exocrine and endocrine pancreatic function, implying that aberrant Oglycans might be relevant for pathogenic mechanisms of the pancreas.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
