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- 저자 : Srinivasan, Sathiyaraj (검색결과 417 건)
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싱가포르의 연령주의 : 현황과 사회적 대응 (Ageism in Singapore)
Srinivasan 한국노년학회 2017 한국노년학회 학술발표논문집 Vol.2017 No.국제학술
Dr. Srinivasan Chokkanathan is currently Assistant Professor at the Department of Social Work, National University of Singapore. He graduated from Voorhees College (B.A. in History), from National Institute of Mental Health and Neuro Sciences,India (MPhil in Psychiatric Social Work), from National University of Singapore, Singapore (Ph.D. in Social Work). His primary area of research involves elder mistreatment, ageism, and older adult’ s mental health. He serves as an invited reviewer for numerous journals on Gerontology such as the Journal of Elder Abuse and Neglect, Aging and Mental Health, Aging and Society, and the Journal of Gerontology: Social Sciences. His publications include 15 peer reviewed articles and 13 presentations in International conferences. He recently was the lead editor in a special issue on social care of elderly in the Journal of Asia Pacific Journal of Social Work and Development
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Methane emission from municipal solid waste dumpsites: A case study of Chennai city in India
Srinivasan, Pavithrapriya,Andimuthu, Ramachandran,S.N., Ahamed Ibrahim,Ramachandran, Prasannavenkatesh,Rajkumar, Easwari,Kandasamy, Palanivelu Techno-Press 2020 Advances in environmental research Vol.9 No.2
The indiscriminate growth in global population poses a threat to the world in handling and disposal of Municipal solid waste. Rapid urban growth increases the production, consumption and generation of Municipal solid waste which leads to a drastic change in the environment. The methane produced from the Municipal Solid waste accounts for up to 11% global anthropogenic emissions, which is a major cause for global warming. This study reports the methane emission estimation using IPCC default, TNO, LandGEM, EPER and close flux chamber from open dump yards at Perungudi and Kodungaiyur in Chennai, India. The result reveals that the methane emission using close flux chamber was in the range of 8.8 Gg/yr-11.3 Gg/yr and 6.1Gg/yr to 9.1 Gg/yr at Kodungaiyur and Perungudi dump yard respectively. The per capita waste generation was estimated based on waste generation and population. The waste generation potential was projected using linear regression model for the period 2017-2050. The trend of CH<sub>4</sub> emission in the actual field measurement were increased every year, similarly the emission trend also increased in IPCC default method (mass balance approach), EPER Germany (zero order decay model) where as TNO and Land GEM (first order decay model) were decreased. The present study reveals that Kodungaiyur dump yard is more vulnerable to methane emission compared to Perungudi dump yard and has more potential in waste to energy conversion mechanisms than compare to Perungudi dump yard.
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Automated Glaucoma Screening in Retinal Fundus Images
Srinivasan Aruchamy,Partha Bhattacharjee,Goutam Sanyal 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.9
Glaucoma is an eye disease which damages the optic nerve that carries information from the eye to the brain. Glaucoma is the second foremost reason of blindness. An efficient hardware based implementation of glaucoma screening is a significant task in the automated retinal image analysis method. This paper presents an automatic glaucoma screening using a TMS320C6416DSK DSP board. The detection procedure consists of two stages. The first stage comprises of image pre-processing and detection of optic nerve head center using circular Hough Transform .In the second stage, the optic disk diameter is calculated and cup is segmented from disk. The proposition between disk and cup is calculated for abnormal image screening. The implemented technique is tested on a publicly available retinal image data sets and the average accuracy achieved is 97.5%.
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Srinivasan Shanmugam,송충길,Santhoshkumar Nagayya-Sriraman,Rengarajan Baskaran,용철순,최한곤,Dae-Duk Kim,우종수,유봉규 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.7
This study was undertaken to evaluate the physicochemical properties and skin permeation of liposome formulations containing clindamycin phosphate (CP), especially when charge was imparted to the liposome. Five different liposome formulations were prepared using Phospholipon 85G (PL) and cholesterol (CH) by conventional lipid film hydration technique. Molar ratio of CH to PL was varied in the range of 0.16-1.0. Charged liposomes were prepared in the same way with addition of 1,2-dioleoyl-3-trimethylammonium-propane chloride salt (DOTAP) and 1,2-dimyristoyl-sn-glycero-3-phosphate monosodium salt (DMPA) as charge carrier lipid for cationic or anionic charge of the liposome, respectively. Fresh full-thickness mice skin was taken and used for skin permeation study using Keshary-Chien diffusion cell with 1.77 ㎠ diffusion area at 37℃. All liposome formulations prepared showed homogeneous size distribution with mean particle size of about 1 μm or less. Among the five liposome formulations prepared, formulation with the molar ratio of 0.5 showed the best result in the physicochemical properties such as polydispersity index, entrapment efficiency, size evolution, and ability of the liposome to retain CP as of entrapped in the vesicles. Charge-impartation of the formulation with cationic charge carrier lipid resulted in additional benefit in terms of inhibition of size evolution, the ability of the liposome to retain CP in the vesicles, and skin permeation. Steady state flux of the drug through the mice skin in the cationic liposome vesicles was 0.75 ± 0.01 μg/㎠h while that in the control (dissolved into mixed alcohol solution) was 0.17 μg/㎠h. One half molar ratio of CH to PL was optimal in terms of physicochemical properties of the liposome formulation containing CP, and incorporation of cationic charge carrier lipid appeared to provide additional benefits for the stability of the liposome formulation and skin permeation of the drug.
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The Effect of 1-Furan-2-yl-3-pyridine-2-yl-propenone on Pharmacokinetic Parameters of Warfarin
Srinivasan Shanmugam,이응석,정태천,용철순,최한곤,우종수,유봉규 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
1-Furan-2-yl-3-pyridine-2-yl-propenone (FPP-3) is an investigatory drug which has a dual inhibitory action on cyclooxygenase (COX) and 5-lipoxygenase (5-LOX). We examined its effect on the pharmacokinetics of warfarin. Three consecutive days of pretreatment with 17 mg/kg of FPP-3 had no significant effect on the pharmacokinetic parameters of warfarin when orally administered to rats. A higher dosage of FPP-3 however, did cause significant changes in the pharmacokinetic parameters of wafarin. The cytochrome P450 activity test demonstrated that the metabolism of R-warfarin was significantly inhibited by FPP-3 while there was little or no inhibition of the metabolism of S-warfarin, which is mainly responsible for its anticoagulant effect. Therefore, it appears that the alteration in the pharmacokinetic parameters of warfarin was due to the inhibitory effect of FPP-3 on the metabolism of R-warfarin. Although there was a significant increase in the plasma concentration, the area under the curve, half life of warfarin, and prothrombin time were not significantly changed. Based on these findings, the pharmacokinetic drug interaction between FPP-3 and warfarin mainly involves R-warfarin and, therefore, this interaction may not be of clinical significance in terms of warfarin-related toxicity.
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( Srinivasan Shanmugam ),( Young Hun Kim ),( Jeong Hee Park ),( Ho Taek Im ),( Young Taek Sohn ),( Kyeong Soo Kim ),( Yong Ll Kim ),( Chul Soon Yong ),( Jong Oh Kim ),( Han Gon Choi ),( Jong Soo Woo ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Aim: The main objective was to investigate the in vitro release profile/kinetics, and in vivo plasma pharmacokinetics (PK) and organ biodistribution (BD) of the prepared sildenafil vaginal suppositories (SVS). Methods: Suppositories containing 25mg of sildenafil were prepared by the cream melting technique using Witepsol H-15 as a suppository base. The suppositories were characterized for weight variation, content uniformity, hardness, disintegration time and crystallinity change. The in vitro dissolution in pH 4.5, and in vivo plasma PK and organ BD of sildenafil from SVS in female Sprague Dawley rats, were also investigated. Results: The mean weight variation, content uniformity, hardness and disintegration time of the prepared SVS were 1.127±0.020g, 98.25±2.50%, 2.5±0.08kg and 9±1.0min, respectively. The release of sildenafil from the SVS was more than 90% at 30min, with a release kinetic of Hixson--Crowell model and non-Fickian diffusion (n=0.464). The plasma PK study demonstrated a significantly lower Cmax (∼10 times) and AUC0-24h (∼13 times) of sildenafil in plasma following intravaginal (IVG) administration of suppositories compared to oral (PO) administration of sildenafil solution. Nevertheless, the organ BD study showed a phenomenally higher Cmax (∼40 times) and AUC0-24h (∼20 times) of sildenafil in uterus following IVG administration of suppositories than PO administration of sildenafil solution. Conclusion: This study demonstrated enhanced sildenafil exposure in the uterus following IVG administration of SVS, which could be used to target the uterus for therapeutic benefits.
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Srinivasan, Kathiravan,Chang, Chuan-Yu,Huang, Chao-Hsi,Chang, Min-Hao,Sharma, Anant,Ankur, Avinash Korea Information Processing Society 2018 Journal of information processing systems Vol.14 No.4
Rapid advances in science and technology with exponential development of smart mobile devices, workstations, supercomputers, smart gadgets and network servers has been witnessed over the past few years. The sudden increase in the Internet population and manifold growth in internet speeds has occasioned the generation of an enormous amount of data, now termed 'big data'. Given this scenario, storage of data on local servers or a personal computer is an issue, which can be resolved by utilizing cloud computing. At present, there are several cloud computing service providers available to resolve the big data issues. This paper establishes a framework that builds Hadoop clusters on the new single-board computer (SBC) Mobile Raspberry Pi. Moreover, these clusters offer facilities for storage as well as computing. Besides the fact that the regular data centers require large amounts of energy for operation, they also need cooling equipment and occupy prime real estate. However, this energy consumption scenario and the physical space constraints can be solved by employing a Mobile Raspberry Pi with Hadoop clusters that provides a cost-effective, low-power, high-speed solution along with micro-data center support for big data. Hadoop provides the required modules for the distributed processing of big data by deploying map-reduce programming approaches. In this work, the performance of SBC clusters and a single computer were compared. It can be observed from the experimental data that the SBC clusters exemplify superior performance to a single computer, by around 20%. Furthermore, the cluster processing speed for large volumes of data can be enhanced by escalating the number of SBC nodes. Data storage is accomplished by using a Hadoop Distributed File System (HDFS), which offers more flexibility and greater scalability than a single computer system.
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Srinivasan Muniyappan,김진해 한국자기공명학회 2019 Journal of the Korean Magnetic Resonance Society Vol.23 No.1
αB-crystallin (αBC) is a member of a small heat-shock protein (sHSP) superfamily and plays a predominant role in cellular protein homeostasis network by rescuing misfolded proteins from irreversible aggregation. αBC assembles into dynamic and polydisperse high molecular weight complexes containing 12 to 48 monomers; this variable stereochemistry of αBC has been linked to quaternary subunit exchange and its chaperone activity. The chaperone activity of αBC poses great potential as therapeutic agents for various neurodegenerative diseases. In this mini-review, we briefly outline the recent advancement in structural characterization of αBCs and its potential role to inhibit protein misfolding and aggregation in various human diseases. In particular, nuclear magnetic resonance (NMR) spectroscopy and its complimentary techniques have contributed much to elucidate highly-dynamic nature of αBCs, among which notable advancements are discussed in detail. We highlight the importance of resolving the structural details of various αBC oligomers, their quaternary dynamics, and structural heterogeneity.
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