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COVID-19에 돌파감염된 노인 환자에서 백신접종 효용성에 대한 고찰
Soobok Choi,Zion Choi,Chul-Min Ha,Hyoung-Ju Lee,Chong myung Kim 대한임상노인의학회 2022 대한임상노인의학회지 Vol.23 No.2
Background: Old age is one of the risk factors for COVID-19, and previous studies, mainly in the U.S., have shown that the COVID-19 vaccine has obvious efficacy in reducing the morbidity and progression to severe disease. This study focused on whether vaccination affects the disease progression in elderly COVID-19 patients in South Korea. Methods: We divided COVID-19 patients over 65 years of age hospitalized at a single medical institution into a vaccinated group and an unvaccinated group, a the progression group and the improvement group, and cross-analyzed them with a chi-square test, and then obtained the odds ratio by binary logistic regression analysis. Results: Of the total patients, 14 (4.3%) in the vaccinated group (n=323) and 29 (23.4%) in the unvaccinated group (n=124) were in the progression group, showing a significant difference (P=0.000). Subsequent binary logistic regression analysis showed that the odds ratio was 0.112 (P=0.000), indicating that vaccination had a significant effect on reducing the progression to severe disease. Conclusion: The COVID-19 vaccine is effective in reducing progression to severe disease in older patients with breakthrough infection, and vaccination is recommended for elderly patients.
고분자형 계면활성제가 마이셀 촉진 한외여과법에 의한 1-나프틸 아민의 제거에 미치는 영향
Youngkook Choi,Soobok Lee,Minok Koo,Yutaka Ishigami,Toshio Kajiuchi 한국막학회 1997 멤브레인 Vol.7 No.3
신규 고분자형 계면활성제(α-allyl-ω-methoxy polyoxyethylene and maleic anhydride block copolymer)를 사용하는 고분자형 마이셀 촉진 한외여과법을 제안하였다. 제거용질로서는 염료의 중간체이며 발암성 물질인 1-나프틸 아민을 사용하였다. 고분자형 마이셀의 촉진효과는 중공사형 폴리아크리로니트릴 막(분획 분자량 6,000, 표면적 0.017m2)을 사용하여 조사하였다. 플럭스의 선형의존성은 0.6kg/cm2까지 유지되었고, 점차 압력증가에 따라 플럭스 증가율은 감소하였다. 고분자형 마이셀을 첨가하지 않은 상태에서의 제거율은 2mM의 용질에 대하여 0.19, 2 wt.%의 고분자를 첨가한 상태에서의 제거율은 0.96이었다 고분자형 마이셀 내부로의 가용화가 분리효율을 5배 촉진시킨 것을 확인하였다. Polymeric micellar enhanced ultrafiltration method using a new type of polyrmer, α-allyl-ω-methoxy polyoxyethlene and maleic anhydride copolymer (AKM-0531, Mw 15, 000), has been proposed to separate 1-naphthylamine as a weak cationic toxic organic solubilizate. Enhancement effect of polymeric micelle was identified by the ultrafiltration runs using polyacryronitrile(PAN) holow fiber membrane with molecular weight cut off 6, 000. The linear dependance of flux on the pressure difference is shown to be valid up to 0.6kg/cm2 and the rate of flux increase in response to change in the pressure is gradually reduced under the pressure difference. Rejection of 0.96 was observed for f mM of 1-naphthylamine with 2 wt.% polymer solution at the conditions of 0.4kg/cm2, natural pH. and 25℃ Solubilization of 1-naphthylamine into the polymeric micelle enhanced the separation efficiency.