http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lim, Beong-Ou,Hong, Doo-Pyo,Yun, June-Yong,Jeoung, Young-Jun,Lee, Ju-Yeon,Chung, Hae-Gon,Choi, Dong-Kug,Choi, Wahn-Soo,Cho, Bong-Gum,Park, Tae-Kyu,Park, Dong-Ki The Korean Society of Medicinal Crop Science 2005 한국약용작물학회지 Vol.13 No.5
Phellinus linteus (PL), one of the immune-regulatory substances, is recognized to play the role in the metabolic process on inflammation and immunity. It has been traditionally used in the oriental medicine to treat inflammatory related disease. The purpose of this study was to evaluate the effects of water extracts of PL on the mesenteric lymph node lymphocytes immune function in the ICR male mice. Control mice received vehicle only. The PL treated mice were administered the respective extract by oral gavages for 4 weeks. IgE concentrations in serum and MLN lymphocytes were significantly lower in PL treated mice than in control mice. PL increased the proportion of $CD4^+\;and\;CD8^+$ T cells in MLN lymphocytes. PL significantly decreased Th2 cytokine concentrations and mRNA expression levels in cytokine secretions. Therefore, water extracts of PL modulate inflammatory parameters through regulation of immunoglobulin production resulting from decreased Th2 cytokine secretion and mRNA expression levels and reduce pro-inflammatory cytokine secretion and mRNA expression in MLN lymphocytes.
Lim, Seong-in,Choe, SeEun,Kim, Ki-Sun,Jeoung, Hye-Young,Cha, Ra Mi,Park, Gil-Soon,Shin, Jihye,Park, Gyu-Nam,Cho, In-Soo,Song, Jae-Young,Hyun, Bang-Hun,Park, Bong-Kyun,An, Dong-Jun Elsevier Ltd. 2019 Vaccine Vol.37 No.27
<P><B>Abstract</B></P> <P>Here, we constructed an attenuated live marker classical swine fever (CSF) vaccine (Flc-LOM-BE<SUP>rns</SUP>) to eradicate CSF. This was done by taking infectious clone Flc-LOM, which is based on an attenuated live CSF vaccine virus (LOM strain), and removing the full-length classical swine fever virus (CSFV) E<SUP>rns</SUP> sequences and the 3′ end (52 base pairs) of the CSFV capsid. These regions were substituted with the full-length bovine viral diarrhoea virus (BVDV) E<SUP>rns</SUP> gene sequence and the 3′ end (52 base pairs) of the BVDV capsid gene. Sows were vaccinated with the Flc-LOM-BE<SUP>rns</SUP> vaccine 3 weeks before insemination and then challenged with virulent CSFV at the early, mid- or late stages of pregnancy. We then examined transplacental transmission to the foetuses. Piglets born to sows vaccinated with Flc-LOM-BE<SUP>rns</SUP> did not show vertical infection, regardless of challenge time. In addition, CSFV challenge did not affect the delivery date, weight or length of the foetus. Pregnant sows inoculated with the Flc-LOM-BE<SUP>rns</SUP> vaccine were anti-CSF E<SUP>rns</SUP> antibody-negative and anti-BVDV E<SUP>rns</SUP> antibody-positive. Challenge of pregnant sows with virulent CSFV resulted in anti-CSF E<SUP>rns</SUP> antibody positivity. These results strongly indicate that differential diagnosis can be conducted between the Flc-LOM-BE<SUP>rns</SUP> vaccinated animal and virulent CSFV affected animal by detecting antibody against BVDV E<SUP>rns</SUP> or CSF E<SUP>rns</SUP> gene. Therefore, the Flc-LOM-BE<SUP>rns</SUP> vaccine may fulfil the function of differential diagnosis which required for DIVA vaccine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Flc-LOM-BE<SUP>rns</SUP> is live attenuated DIVA vaccine for CSFV. </LI> <LI> The Flc-LOM-BE<SUP>rns</SUP> vaccine protected foetuses from vertical transmission. </LI> <LI> The Flc-LOM-BE<SUP>rns</SUP> vaccine enables differential identification of serum antibodies. </LI> </UL> </P>
Beong-Ou Lim,Doo-Pyo Hong,June-Yong Yun,Young-Jun Jeoung,Ju-Yeon Lee,Hae-Gon Chung,Dong-Kug Choi,Wahn-Soo Choi,Bong-Gum Cho,Tae-Kyu Park,Dong-Ki Park 한국약용작물학회 2005 한국약용작물학회지 Vol.13 No.5
Phellinus linteus (PL), one of the immune-regulatory substances, is recognized to play the role in the metabolic process on inflammation and immunity. It has been traditionally used in the oriental medicine to treat inflammatory related disease. The purpose of this study was to evaluate the effects of water extracts of PL on the mesenteric lymph node lymphocytes immune function in the ICR male mice. Control mice received vehicle only. The PL treated mice were administered the respective extract by oral gavages for 4 weeks. IgE concentrations in serum and MLN lymphocytes were significantly lower in PL treated mice than in control mice. PL increased the proportion of CD4+ and CD8+ T cells in MLN lymphocytes. PL significantly decreased Th2 cytokine concentrations and mRNA expression levels in cytokine secretions. Therefore, water extracts of PL modulate inflammatory parameters through regulation of immunoglobulin production resulting from decreased Th2 cytokine secretion and mRNA expression levels and reduce pro-inflammatory cytokine secretion and mRNA expression in MLN lymphocytes.