Poster Session : PS 0354 ; Epidemiology and Public Health : Prevalence and Associating Factors with Atypical Femoral Fractures: An Asian Single Center Based Case-Control Study

( Dam Kim ),( Yoon Kyoung Sung ),( Soo Kyung Cho ),( Mink Yung Han ),( Yee Suk Kim ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Current evidence suggests that there is an association between bisphosphonate use and atypical femoral fractures (AFFs). However, the extent of this risk remains unclear, especially in Asian population. In this study, we aimed to estimate the proportion of AFFs among total patients with femoral fractures and to compare the characteristics of patients with AFFs with that of patients with classic femoral fractures (CFFs). Methods: A total of 578 female patients with low-energy femoral fractures who had been hospitalized at an Asian single university hospital were retrospectively enrolled. Patients were classifi ed into two groups according to the site of fracture: AFF group for patients with subtrochanteric or diaphyseal femoral fractures and CFF group for patients with intertrochateric or neck fractures. We assessed the association of bisphosphonate use and AFFs with using multivariate logistic regression analysis. Results: Twenty-seven patients (4. 7%) with AFFs and 551 patients (95. 3%) with CFFs were identifi ed. Of the patients with AFFs, 11 (40. 7%) had been treated with bisphosphonates compared with 40 (7. 3%) in the CFF group. With adjusting the age, body mass index, types of injury (slip or fall), and history of rheumatoid arthritis, bisphosphonate was the only predictor for atypical fractures (OR 9. 8, CI 3. 7-26. 4). Among the patients with using bisphosphonate when they fractured (n=44), the proportionof AFFs was nearly 21% (n=9). The proportions of AFFs among femoral fractures were increased according to the duration of bisphosphonate; 15. 4% (n=6) in patients with <5 years and 60% (n=3) in patients =5 years, respectively. Conclusions: The proportion of AFFs was around 5% among the patients with femoral fractures and AFF were associated with bisphosphonate use in Asian ethnicity. Longer duration of treatment resulted in augmented risk, though any period in bisphosphonate use could cause atypical femur fracture.

Prevalence and Associated Factors for Non-adherence in Patients with Rheumatoid Arthritis

( Dam Kim ),( Ji-young Choi ),( Soo-Kyung Cho ),( Chan-Bum Choi ),( So-Young Bang ),( Hoon-Suk Cha ),( Jung-Yoon Choe ),( Won Tae Chung ),( Seung-Jae Hong ),( Tae-Hwan Kim ),( Tae-Jong Kim ),( Eunmi K 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.1

Objective. To estimate the prevalence of non-adherence to rheumatoid arthritis (RA) medication and identify the associated factors for non-adherence in RA patients. Methods. Among the KORean Observational study Network for Arthritis 3,523 patients who completed a questionnaire about the adherence to RA medication were analyzed. The patients were divided into two groups: 1) adherent group, patients who skipped medication ≤5 days within the past 2 months; and 2) non-adherent group, patients who skipped ≥6 days of medication. The baseline characteristics were compared, and multivariable regression analysis was performed to identify the associated factors for non-adherence. Results. The non-adherent group had 339 patients (9.6%). The common causes of non-adherence were forgetfulness (45.8%), absence of RA symptoms (24.7%), and discomfort with RA medication (13.1%). Younger age (odds ratio [OR] 1.02, p<0.01) and higher income (OR 1.70, p<0.01) were associated with an increased risk of non-adherence. Whereas higher functional disability (OR 0.68, p<0.01) and oral corticosteroid use (OR 0.73, p=0.02) were associated with a decreased risk of non-adherence. The associated factors differed according to cause of non-adherence. Having adverse events (OR 2.65, p=0.02) was associated with the risk of non-adherence due to discomfort with RA medication while a higher level of education (OR 2.37, p=0.03) was associated with the risk of non-adherence due to an absence of RA symptoms. Conclusion. The 9.6% of Korean RA patients were non-adherent to RA medication. The associated factors differed according to the cause of non-adherence. Therefore, an individualized approach will be needed to improve the adherence to RA medication. (J Rheum Dis 2018;25:47-57)

Cardiovascular and Gastrointestinal Effects of Etoricoxib in the Treatment of Osteoarthritis: A Systematic Review and Network Meta-analysis

( Dam Kim ),( Soo-kyung Cho ),( Seoung Wan Nam ),( Hyuk Hee Kwon ),( Sun-young Jung ),( Chan Hong Jeon ),( Seul Gi Im ),( Dalho Kim ),( Eun Jin Jang ),( Yoon-kyoung Sung ) 대한류마티스학회 2017 대한류마티스학회지 Vol.24 No.5

Objective. To estimate the cardiovascular (CV) and gastrointestinal (GI) risks of etoricoxib in the treatment of osteoarthritis (OA) compared to a placebo and other non-steroidal anti-inflammatory drugs (NSAIDs). Methods. A systematic review of randomized, controlled trials (RCTs) of etoricoxib were performed. Bayesian network meta-analysis was used over a duration of 12 weeks. The incidence of CV and GI events for a duration ≥26 weeks were also tabulated and presented using descriptive statistics. Results. From this search, 10 studies were identified. Of these, 6 and 5 RCTs that measured the CV and GI events at 12 weeks were included in meta-analysis. They showed that etoricoxib did not increase the CV events compared to the placebo or NSAIDs during the 12 week period (odds ratio [OR]=0.59 compared to celecoxib, OR=0.89 with ibuprofen, OR=0.70 with placebo, and OR=2.16 with naproxen). The risk of GI events was comparable to that of most comparators, with the exception of naproxen, which had a significantly lower risk of GI events (OR=0.18) during the 12 week period. For a duration ≥26 weeks, the incidence of CV and GI events with etoricoxib increased with increasing duration. Conclusion. Etoricoxib is an alternative short-term treatment option for OA, showing comparable CV and GI complications to other NSAIDs. Nevertheless, further studies will be needed to elucidate the long-term safety of etoricoxib in the treatment of OA. (J Rheum Dis 2017;24:293-302)

Characteristics of Desulfatated Agar by Arylsulfatase-Displayed Yeast Biocatalyst

Eun-Soo CHO,Woo-Dam EONG,Jeong-Hwan KIM,Yeon-Hee KIM,Soo-Wan NAM 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.10

Effect of carbonization temperature on crystalline structure and properties of isotropic pitch-based carbon fiber

Jung Dam Kim,Jae-Seung Roh,Myung-Soo Kim 한국탄소학회 2017 Carbon Letters Vol.21 No.-

Isotropic pitch-based fibers produced from coal tar pitch with the melt-blowing method were carbonized at temperatures ranging from 800 to 1600oC to investigate their crystalline structure and physical properties as a function of the carbonization temperature. The in-plane crystallite size (La) of the carbonized pitch fiber from X-ray diffraction increased monotonously by increasing the carbonization temperature resulting in a gradual increase in the electrical conductivity from 169 to 3800 S/cm. However, the variation in the d002 spacing and stacking height of the crystallite (Lc) showed that the structural order perpendicular to the graphene planes got worse in carbonization temperatures from 800 to 1200oC probably due to randomization through the process of gas evolution; however, structural ordering eventually occurred at around 1400oC. For the carbonized pitch powder without stabilization, structural ordering perpendicular to the graphene planes occurred at around 800–900oC indicating that oxygen was inserted during the stabilization process. Additionally, the shear stress that occurred during the melt-blowing process might interfere with the crystallization of the CPF.

경제적인 NTC 세라믹스 온도센서 시스템을 이용한 콘크리트 수화열 계측에 관한 실험적 연구

김기수(Kim, Ki Soo),김종우(Kim, Jong Woo),전재홍(Jun, Jae Hong),하재담(Ha, Jae Dam),김태홍(Kim, Tae Hong) 한국콘크리트학회 2001 한국콘크리트학회 학술대회 논문집 Vol.2001 No.11

안정화 조건에 따른 석탄계 피치 탄소섬유의 물성

김정담(Jung-dam Kim),김명수(Myung-Soo Kim) 한국고분자학회 2018 폴리머 Vol.42 No.1

피치계 탄소섬유의 제조공정은 방사, 안정화 및 탄화로 나뉘고, 그 중 안정화 공정은 긴 처리시간과 많은 비용을 필요로 한다. 안정화 공정의 최적조건을 결정하기 위하여 안정화가 진행된 정도를 나타내는 SI(stabilization index)를 도입하여 계산하였고, 안정화 조건에 따른 탄화섬유의 물성 변화를 조사하였다. 안정화 시간 0 및 1시간에서, 안정화 온도를 연화점+0~50 ℃로 변화시키면서 안정화섬유 및 탄화섬유의 특성을 분석하였다. 탄화섬유의 기계적 물성 및 전기전도도 특성에 의해 안정화 유지시간 0시간에서 안정화 온도 SP+30 ℃를, 안정화 유지시간 1시간에서 안정화 온도 SP+10 ℃를 최적의 안정화 조건으로 결정하였다. 두 조건에서 안정화 정도에 따라 증가되는 안정화 섬유의 산소의 함량은 약 7.2%이었다. The manufacturing process of pitch-based carbon fiber was divided into spinning, stabilization and carbonization. Among them, the stabilization process requires long time and high cost. In order to determine the optimal stabilization conditions, we calculated the stabilization index (SI), which means the degree of stabilization, and investigated the correlation between SI and physical properties of carbonized fibers with changing the stabilization conditions. With the stabilization times of 0 h and 1 h, the stabilization temperatures were changed from SP+0 ℃ to SP+50 ℃, and the resulting stabilized and carbonized fibers were characterized. For tensile properties and electrical conductivity, a stabilization temperature of SP+30 ℃ with 0 h duration and a stabilization temperature of SP+10 ℃ with 1 h duration were determined as the optimal stabilization conditions. At these conditions, the oxygen contents of stabilized fibers, which increased according to the degree of stabilization, were around 7.2%.

아태지역 양성평등 정책 인프라 강화 사업(Ⅶ)

장은하(Eun Ha Chang),김은경(Eun Kyung Kim),조혜승(Hye Seung Cho),김정수(Jung Soo Kim),김신아(Shin Ah Kim),박윤정(Yoon Jung Park),이지현(Ji Hyun Lee),최소담(So Dam Choi),김경량(Kyung Ryang Kim),장지순(Ji Soon Chang) 한국여성정책연구원(구 한국여성개발원) 2017 한국여성정책연구원 연구보고서 Vol.2017 No.-

Ⅰ. 서론 1. 연구목적 및 필요성 ○ 젠더이슈는 하나로서 국제사회의 개발협력 논의에 있어서 끊임없이 강조되어오고 있음. 2000년 이후 UN 중심의 국제사회의 개발을 향한 의지를 담은 새천년개발목표(Millennium Development Goals, 이하 MDGs)와 지속가능발전목표(Sustainable Development Goals, 이하 SDGs)와, OECD 개발원조위원회(DAC)에서도 개발효과성 제고를 위한 성평등 이슈의 중요성이 지속적으로 강조되고 있음. ○ 한국은 2010년도 OECD 개발원조위원회(DAC)에 가입하여 개도국에 대한 지원 및 국제사회에서의 기여를 증대시키기 위해 지속적으로 노력해오고 있으나, 성평등 및 여성역량강화를 위한 원조의 비율은 12% 수준으로 전체 DAC 회원국의 평균에 크게 못 미치는 등 성평등 원조에 있어서는 여전히 많은 개선이 필요한 실정임. ○ 이러한 대내외적 필요성에 부응하여 2011년도부터 시작된 본 ODA 연구과제는 다차년도 연구로서 해마다 그 주제를 확장해오면서 아태지역 한국의 중점협력국 4개국(캄보디아, 인도네시아, 미얀마, 베트남)의 양성평등 정책의 발전과 이를 지원하기 위한 한국의 ODA 정책방향을 고민해옴. ○ 특별히, 금년도 연구의 경우, 2015년 발표된 ‘소녀들의 보다 나은 삶(Better Life for Girls, 이하 BLG)’ 구상에 발맞추어 아태지역의 중점협력국 4개국(캄보디아, 인도네시아, 미얀마, 베트남)의 소녀 관련 현지 수요를 파악하고, 소녀 관련 향후 한국 ODA 정책 방향을 제시하는 것을 그 목적으로 함. 2. 연구방법 및 내용 ○ 본 연구보고서는 본원의 ODA 사업의 다양한 활동에 따른 산출물 중 하나로서, 사업의 주요 프로그램들을 반영하여 구성한 보고서임. 따라서 학술적 연구에서 요구되는 방법론을 엄격히 적용하기는 어려운 구조적인 한계가 있으며, 이로 인해 보다 현장성을 반영한 연구로 진행함. ○ 본 연구사업은 2011년도부터 아태지역 4개 중점협력국 (캄보디아, 인도네시아, 미얀마, 베트남)을 대상으로 양성평등 정책 인프라 변화와 한국의 성평등 원조사업 증가라는 두 가지 목표를 가지고 진행되어 왔음. ○ 세부내용은 1) 초청연수, 2) 공동 연구, 3) 한국 여성정책 발전경험 공유, 4) 기타 연구활동으로 구성됨. ○ 초청연수 - 금년도 초청연수는 ‘소녀 및 청년여성의 역량강화(Empowerment of Girls and Young Women)’을 주제로 개최되었으며(2017. 9. 4. ~ 2017. 9. 8.), 4개 협력국(캄보디아, 인도네시아, 미얀마, 베트남)의 소녀 관련 정책을 담당하는 공무원 및 NGO, 학계 전문가 29인이 초청되었음. ○ 협력국 공동연구 - 협력국 공동연구의 경우, 4개국(캄보디아, 인도네시아, 미얀마, 베트남)의 여성 및 여아에 대한 현황분석을 실시하고 이를 통해 향후 관련 개발협력 수요발굴 및 현지의 정책 형성에 기여하고자 하였음. ○ 한국 여성정책 발전경험 공유 - 금년도의 경우, 한국이 비교우위를 갖는 여아 및 청소녀 관련 정책 및 사업 경험(아동성매매 신상공개, 남아 선호 사상 감소, 젠더 관점의 교과서 개정)을 사례연구화하여 협력국 정책전문가들과 공유함. ○ 기타 연구활동으로 문헌조사, 협력국 출장을 통한 모범사례 발굴, BLG 중점 협력국의 개발협력사례 분석, 젠더와 ODA 포럼, 성과평가 등의 활동을 진행함. ○ 보고서의 구성은 다음과 같음. - 제 1장 서론에서는 연구 목적 및 필요성, 내용과 방법, 그리고 기여도에 대해서 설명함. - 제 2장에서는 개발협력 분야에서의 소녀관련 선행연구를 BLG의 세 영역인 교육, 보건, 미래역량을 중심으로 검토하며, 소녀들의 보다 나은 삶을 위한 핵심요소인 젠더폭력에 대해서도 고찰함. - 제 3장에서는 본원 ODA 사업의 4개 협력국(캄보디아, 인도네시아, 미얀마, 베트남)의 소녀현황을 교육, 보건, 미래역량, 젠더폭력의 네 개 분야로 나누어 분석하고 수요분야를 도출함. - 제 4장에서는 협력국의 소녀관련 정책수립에 참고할 수 있는 국내외 소녀 관련 모범 정책 및 사례를 소개하며 마지막으로 5장에서는 문헌연구, 협력국 현지의 소녀현황, 모범사례를 바탕으로 국별, 분야별 종합적인 제언을 제시함. KWDI has been conducting a multi-year ODA research project since 2011 with an objective of establishing political and social infrastructure for gender equality policy in the Asia-Pacific region. During the year 2011 ? 2012, KWDI partnered with Cambodia and Indonesia and carried out various programs including baseline surveys, policy dialogues, and capacity building training. From 2013, KWDI expanded the project to include Myanmar and Vietnam as additional partners. Now KWDI is working with these four countries, sharing each other’s experiences and deepening mutual learning. This year’s research report was initiated to identify local demands for women and girls in developing countries on the basis of the ‘Better Life for Girls (BLG)’ initiative announced by the South Korean Government in 2016, and to propose future direction of Korean ODA policy. The research aims to identify the local demands of girls for project planning and implementation to realize the BLG initiative in the Asia-Pacific partner countries of Cambodia, Indonesia, Myanmar, and Vietnam, and to suggest future policy implications for Korean ODA. Chapter 2 examines the preliminary research on girls in the field of development and cooperation by conducting literature review on three areas of the BGL initiative: education, health, and profession. In addition to the focus areas of the BGL, the chapter also conducts survey on literature of gender-based violence (GBV) against girls in terms of sexual violence, and harmful customs and practices. It then explores existing global framework on girls research and project and identifies the role of KWDI ODA in macro-discourse level. Chapter 3 analyzes the current situation of girls in KWDI’s four partner countries (Cambodia, Indonesia, Myanmar, and Vietnam) centering on the aforementioned four focus areas: education, health, profession, and gender-based violence. Then, the chapter identifies core priority areas to realize a better life for girls by country and sector. Chapter 4 looks into domestic and international girls-related best policies and projects in three sections. The first section of the chapter summarizes one of the programs of this ODA project, that is, ‘Knowledge Sharing on Korea’s Development in Women’s Policies.’ It analyzed three topics: decline of son preference, law and policy on the public disclosure of child sex traffickers information, and gender-sensitive textbook revision in South Korea. The second section introduces South Korea’s best policy practices related with girls. They are: Center for Teen Women’s Human Rights (Teens-Up), Tacteen Naeil, and Mirim Girls’ Information Science High School, for which cases were introduced as a field trip sites during the 2017 KWDI SSAGE Workshop. The third section introduces three international best projects in regards to girls: UNICEF Nepal’s ‘Rupantaran,’ the World Bank’s Adolescent Girls Initiative(AGI) in Lao PDR and ‘Supporting Talent, Entrepreneurial Potential and Success (STEPS)’ project, and the Child Fund’s ‘Pass It Back’ program. By analyzing of best policies and projects, the Chapter concludes with an exploration of key factors for girls’ empowerment in four countries and the applicability of such factors. Chapter 5 presents political implications for girls empowerment in four countries based on the literature review, the girls situation analysis of each partner country, and best practices review conducted in previous chapters. The report concludes with sectoral policy recommendations for Korea as well as donor nations and examines future research and project directions. The sectoral policy recommendations are based on the particular areas presented by the BGL and SDGs and are proposed by taking specific cases and applicability into account.

Immunohistochemical distributions of ClC-2 expression in the GABAergic interneurons following Febrile seizures (FS)

Yeon Hee Yu,Ji-Heon Jeong,Kahyun Lee,Shin Young Kim,Seo Yeon Kim,Ki Dam Kim,Dae-Kyoon Park,Kyung-Ho Park,Duk-Soo Kim 대한체질인류학회 2015 대한체질인류학회 학술대회 연제 초록 Vol.58 No.-

S-681 Adverse Events and Persistency of Biologics in RA Patients with Interstitial Lung Disease

( Dam Kim ),( Soo-kyung Cho ),( Soyoung Won ),( Hoon-suk Cha ),( Chan-bum Choi ),( Seung-jae Hong ),( Jisoo Lee ),( Dong Hyuk Sheen ),( Dae-hyun Yoo ),( Sang-cheol Bae ),( Yoon-kyoung Sung ) 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1

Objectives: We aimed to compare the incidence of adverse events (AEs) and persistency of biologics in RA patients with or without ILD. Methods: A total of 981 RA patients with chest radiograph or chest computed tomography (CT) data at enrollment were extracted from BIOlogics Pharmacoepidemiologic StudY (BIOPSY) cohort, a nationwide multicenter prospective cohort for biologic users of RA patients in Korea. We classified them into two groups: 1) RA-ILD group as patients with ILD, and 2) RA-non ILD group as patients without ILD. We compared the incidence of AEs during use of biologics between two groups, and then tested the differences of drug discontinuation rates due to AEs, infection, and respiratory infection between RA-ILD and RA-non ILD groups using Kaplan-Meier survival analysis and log-rank test. In addition, Cox proportional hazard model were used to identify the impact of ILD on AEs in RA patients with biologics. Results: The 42 patients (4.3%) revealed to have RA-ILD by chest radiograph or chest CT. Patients in RA-ILD group were older (p<0.01), and male patients were more in RA-ILD group (p<0.01). During mean follow-up of 20 months with 1,611 person years (PY), the incidence of AEs was higher in RA-ILD group (IRR 1.55, CI 1.11-2.17). In addition, the incidence of infection and respiratory infection were higher in RA-ILD group (IRR 2.38, CI 1.32-4.30 for infection, IRR 3.00, CI 1.50-5.99 for respiratory infection, respectively). The biologics discontinuation rate due to AEs was comparable in two groups (p=0.13), whereas the biologics discontinuation rate due to infection (p=0.03) and respiratory infection (p<0.01) were significantly higher in RA-ILD group. After adjusting for variables, age (HR 1.27, CI 1.15-1.41) and having ILD (HR 10.77, CI 2.26-51.41) were risk factors for mortality in RA patients with biologics. Conclusions: The incidence of adverse events, especially respiratory infections were higher in RA-ILD patients with biologics compared with RA-non ILD patients. In addition, the biologics discontinuation rate due to infection, especially respiratory infection was significantly higher in RA-ILD patients. Concerning the mortality, ILD increased the mortality in RA patients with biologics.