정신분열증 환자의 전기치료후 증상 변화와 혈장 Prolaction, ACTH, Cortisol치 변화에 관한 연구

남수용,우행원 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

The purpose of this study was to observe the changes in the levels of PRL, ACTH and cortisol and clinical symptoms after ECT of schizophrenic patients and to find out the correlations between the effect of ECT on hypothalamic-pituitary axis and clinical symptoms. The subjects were 15 inpatients who met DSM-Ⅲ-R diagnonsitic criteria for schizophrenia and ECT was applied to them 8 times. Venous blood was sampled 15 minutes before(preECT) and after(postECT) the 1st and 8th ECT. Plasma levels of PRL, ACTH and cortisol were measured by RIA. Clinical symptoms were assessed before 1st ECT and after the 8th ECT by BPRS. The results are as follows: 1) After the 8th ECT, BPRS scores, especially thinking disturbance and withdrawl/retardation were significantly decreased as compared to those before the 1st ECT(p<0.01). 2) Plasma levels of postECT PRL, ACTH and cortisol were significantly higher than preECT levels of the 1st and 8th ECT. 3) Plasma levels of preECT PRL at 8th ECT were significantly lower than the baseline levels(p<0.05). In conclusion, the changes in the levels of PRL, ACTH and cortisol after ECT were caused by the changes of activity of central neurotransmitters, result in the improvement of schizophrenic symptoms. In particular, repeated ECT were related to an increase in the activity of dopaminergic receptor, which can explain the effect of ECT on the improvement of negative symptoms in chronic schizophrenia.

당뇨병환자에서 호흡이 심박수에 미치는 영향

남수현,오용구,박경욱,윤영길 慶北大學校 醫科大學 1981 慶北醫大誌 Vol.22 No.1

당뇨병환자에서 자율신경 기능장애를 알아내기 위한 검사로서 심호기 심흡기율이 건강인에 비해 떨어져 있음을 심전도를 이용하여 검사하므로서 환자 침대에서 간단하게 그리고 정확하게 검사할 수 있었다. 당뇨병환자는 안정시 정상인에 비해 빈맥이 있으며, 심박수의 감소 또한 유의하게 적었다. 특히 건반사가 이상이 있는 당뇨병환자에서 건반사가 정상인 환자에 비해 심박수의 변화가 유의하게 적었으며 건반사가 이상인 환자에서 심흡기 심호기율이 1.10 이하는 56명중 49명으로 88%나 되었다. Retinopathy가 있는 환자에서 역시 심박수의 변화는 유의하게 적었고 심흡기 심호기 율이 1.10 이하인 예가 47명중 38명으로 78%나 되었다. 또한 단백뇨가 있는 환자에서도 심박수의 변화는 그 정도는 낮았으나 유의하게 적었다. 당뇨병의 병력기간이 길수록 심흡기 심호기율은 더 작아지는 경향은 확실하며 저자의 예에서는 병력기간이 1년이상 5년이하까지는 1.11±0.21 이였고, 5년이 넘어서서 10년 이하에서 1.07±0.03으로 1.10을 하회(下廻)하였다. 이와 같은 성적으로 미루어 보아 심호흡시 흡기 호기의 율을 계산함으로써 외과수술환자의 급성심폐부전에 의한 높은 사망율을 줄이는 데는 많은 도움이 될 것이다. To find a simple and accurate test of autonomic nervous dysfunction in diabetes mellitus, we performed maximal deep breathing procedures while undergoing electrocardiographic recording at bed side. Normal indivisuals at rest show variation in heart rate induced by respiration. During maximal deep breathing these changes are accelltuated and electrocardiographic recording will show the increase in heart rate during inspiration and the decrease during expiration. This variation is reduced or abscent in diabetics with autonomic neuropathy. Forty eight of the 56 with sensory neuropathy(88%) had an DE/Dl ratio below of 1.10. Diabetics with retinopathy also had significantly smallest variation and thirthy eight of the 47 with retinopathy(78%) had an DE/DI ratio below of 1.10. Also diabetics with proteinuria had significantly smaller variation. Relation between duration of diabetics and DE/DI ratio was inverse proportion accurately. For example in diabeticc of duration which above 1 year and below 5 years DE/DI ratio was 1.11±0.21 and in diabtiecs with below 10 years duration was 1.07±0.03. Our study cleary shows that diabetics with sensory neuropathy have a high prevalence of autonomic dysfunction, with may be important clinically. Since sudden cardiorespiratory deaths are common in diabetics with autonomic neuropathy during and after sugery, the determination of the DE/DI ratio might be a suitable preoperative test for those diabetics at risk. Patients with an abnormal ratio should probably be closely monitered in an intensive care unit after operation.

소아나 협조가 힘든 환자에서 봉합사 제거가 쉬운 봉합법

남수봉,오흥찬,강철욱,최수종,배용찬 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

이담자균 효모의 성분화 과정중 인지질의 작용과 배지조성의 제한이 성분화에 미치는 영향

정영기,강원대,남수완 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

The action of phospholipid on the rhodotorucine A(Rh.A) acceptance by heterobasidiomyceteous yeast Rhodospori-dium toruloides mating type a cells and the effect of medium composition during sexual differentiation were investigated. Activation of trigger peptidase(TPase) was very sensitive to the originated phospholipid from R. toruloides and was more sensitive to phospholipid liposome made up of phospholipid. Phospholipid present on the membrane of mating type a cells consists of phospatidylglycerol(PG), phosphatidylethanolamine(PE), phospatidylcholine(PC), phospatidylinositol(PI), and phosphatidylserine(PS) of 12.9, suprisingly 45.4, 11.0, and 13.9%, respectively. As the result of using C-1 and N-1 mediums which limited C and N sources capable of inhibiting the synthesis of phospholipid. it resulted inhibiting sexual differentiation and production of Rh.A from mating type A cells.

2단계 발효에 의한 포도식초와 재래식 포도식초의 품질 비교

정용진,이명희,서권일,김주남,이용수 동아시아식생활학회 1998 동아시아식생활학회지 Vol.8 No.4

Grape vinegar(A) and grape onion vinegar(B) added (3% of onion juice) were produced through two stages of fermentation(alcohol fermentation and acetic acid fermentation) to increase the grape's use. Grape wine which contained 5.6% alcohol was produced on the 3rd day of first stage. Then through the second stages, grape vinegar, of which total acidity was 5.37% was produced. The quality of (A) and (B) which was produced through the two stages of fermentation was compared with the traditional grape vinegar(C,D) in the market. The content of sugar in (D) was a little higher such as 5.4 °Brix than others. That of (A) and (B) was 5.13, 4.98 °Brix respectively. The content of remaining alcohol in (C) was high such as 0.23% comparatively, But there was no remaining alcohol in (A) and (B). The content of acetic acid was 4.3~5.3% as a major organic acid of vinegars. The content of tartaric acid was 340.0 in (A), 316.7 in (B), 322.6 in (C) and 391.7㎎% in (D). The content of lactic acid was distinctly high such as 277.4㎎% in (D). There were differences such as 9.2~15.5㎎% in the content of total free amino acids among grape vinegars. (D) contained 15.5㎎% of total free amino acid and (B) also highly such as 12.0㎎%. Potassium was high in grape vinegars. The content of potassium, sodium and copper was higher in (A) than (B).

서남해안 지방에서 발생한 Vibrio vulnificus 감염의 임상적 고찰

조남수,김춘호,김성중,김용배,조수형,안태훈 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: V. vulnificus infection in found between May and October when the man who has hepatic disorder or immunity disorder eats raw shellfish and it causes the systemic symptoms such as sudden fever, chilling, shock and stupor and local skin lesions like bleb and necrosis. This disease has 46∼61% of fatality rate in spite of intensive treatment. This study conducts the examination of history, epidemic study, ingesting raw fish and bacteriologic investigation in the patients with similar clinical symptoms to the above and examines the diagnostic dorrelations. Method: It is conducted with 31 cases who admitted at emergency medical center of Chosun University Hospital from May of 1995 to September of 1998 and are suspected to have V.vulnificus infection. It analyze bacteriologic examination, the survey of residence, eating raw shellfish, hepatic disorder, alcohol drinking habits and skin lesion. Results: 1) The rate of male and female is 15.5:1 and in the age, 18 cases are in fifties, seven are in forties and six are over sixties. 2) Clinically, V.vulnificus is detected in 20 of 31 cases which is suspected to have V.vulnificus infection and it is not detected in 5 cases. Other bacteria are detected in 6 cases and they include staphylococcus aureus, pseudomonas species, β-hemolytic streptococcus and E-coil. 3) In local distribution, Kohung has 10 cases, Shinan and Mokpo have six, Haenam and Kangjin have five, Yongkwang and Muan have five, Naju and Yongam have five and Kwangju has one. 4) Eating fishes and raw shellfishes is found in 31 cases. In the kind of shellfishes, eating raw clam is 10 cases, raw thin-shelled surf calm is 8 cases, raw oyster is 5 cases and sliced raw fish is 4 cases and pickled sea foods are 4 cases. 5) The cases with hepatic disorder are 23 and 15 cases with heavy alcohol drinking Carrier are included. The cases with Diabetic Mellitus are four and those with pulmonary tuberculosis are two. Two cases have not basal diseases. 6) On the opinion of skin lesion, 20 cases show vesicular necrosis, 7 cases have dendriform erythema, 3 cases have papule and one case doesn't show clear skin lesion. Conclusion: When V.vulnificus infection is detected, it is fatal and those who have hepatic disorder or heavy alcohol drinking habit must avoid eating fishes and shellfishes raw in summer. It is important to have emergency treatment for the patient whose V.vulnificus infection is suspected. It is considered that the administration of initial antibiotics is effective by generalizing the clinical symptom, epidemic opinion and patient history even before the results of bacteriologic confirmed.

신장의 사춘기 성장 동안 초경 발생 시기와 성장 곡선의 형태에 관한 연구

안용수,이기수,남종현,강윤구 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.3

이 연구는 만 7세부터 17세까지의 신장의 누년적 변화를 통해서 사춘기 최대 성장기와 초경 발생 시기와의 관계를 평가하고, 성장 곡선의 형태에 따라 성장 곡선을 분류하여 각 형태별 특징을 파악하고자 시행하였다. 경기도 화성에 있는 삼괴 고등학교에서 1학년부터 3학년까지 96명의 생활기록부에 기재되어 있는 신장의 누년적인 자료가 이용되었으며, 초경 시기와 전신적 질환 유무는 설문지를 통해 조사되었다. 사춘기 성장 가속기는 9.9세에 시작하여 11.6세에 최대 성장기를 이루고 14.1세경에 끝났다. 초경은 12.6세에 일어나며 76.1%는 최대 성장기 이후에 나타나고 최대 성장기와는 1년의 차이를 보인다. 10.4%에서 최대 성장기 전에 초경이 나타났고 13.5%에서는 최대 성장기와 동일한 시점에 나타났다. 초경 시기와 관계없이 사춘기 성장 가속 기간은 4.2년으로 일정하게 나타난다. 성장 곡선을 4가지 형태로 분류하였으며, A형은 51.1%, B형은 21.9%, C형은 20.8%, D형은 6.2%의 분포를 보인다. C형의 성장 가속 기간이 가장 길게 나타난다. B형과 C형에서 PHV가 두 개인 경우는 B형과 C형의 58.5%인 24명에서 나타났다. 이상의 연구 결과에서 개개인의 성장 양상은 개인차가 크며 초경뿐만 아니라 누년적인 성장을 참고로 하여 onset의 정확한 시기와 성장 곡선 형태를 파악할 수 있다면 남은 성장 기간 예측에 도움을 줄 것으로 생각된다. Objective: This study investigated the onset, peak height velocity (PHV) and end of adolescent growth spurt as well as menarcheal timing deduced from surveying accumulative height growth over many years. Methods: Ninety six students of Samgoe high school between 1st and 3rd grade that were in good health participated in the research. A survey questionnaire was distributed to examine the students’ health status and menarche timing. Results: Adolescent growth spurt typically began at the age of 9.9 and reached a PHV at the age of 11.6. The growth spurt ended at the age of 14.1 on average. The average age of menarche was 12.6 years, which was about one year after the PHV of adolescent growth spurt. In most cases, menarche came after PHV. But in 24% of the students, menarche and PHV was nearly coincident or menarche preceded PHV. The growth curves were classified into four types. A typical adolescent growth spurt showed one PHV on graph that drastically drops after the PHV. However, there were cases with two PHVs. Conclusions: The results indicate that individual growth patterns show large individual differences, however the categorization into the various growth curves may aid in predicting individual growth patterns.

유소아 응급처치시 Ketamine hydrochloride의 효과

조남수,이경운,김용배 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2

Our study was made on 96 cases of ketamine anesthesia, who visited to emergency department of Chosun university hospital. This patient was not controlled by verbal order and lidocaine anesthesia, and indication for the use of ketamine(from 1 to 5 years old). Dosage of ketamine in the intramuscular injection was 5mg/kg, in the intravenous injection was 2mg/kg. The results were as follows; 1. After the ketamine injected, expending time doing induction was for 2∼4 minutes in cases of intramuscular injection, and expending time doing induction was for 20∼60 seconds in cases of intravenous injection 2. After the ketamine injected, patient`s awake time was 50±5 minutes in case of intramuscular injection, and that is 20±5 minutes in cases of intravenous injection. 3. Injected ketamine caused increased blood pressure, pulse rate, and respiration rate, and saturation of oxygen was maintained 92-98% level. 4. In adverse effect, the presence of spontaneous eye opening, mild a groan, purposeless involuntary movement and increased excretion of saliva was appeared. 5. Advantage of ketamine injection was that one attendant was enough for restraining the patient, and reduced pain sense, and operator performed various procedures easily on stable condition. From the above results, it was considered in emergency department that indications for ketamine anesthesia are primary closure of simple facial laceration, burn dressing, and some diagnostic procedures( cardiac & ureteric catheterization, cystoscopy) in pediatric patients. It was considered, that all procedures should be performed under fullfill all the condition such as professional control devices(esp. central monitoring system) and basic CPR instruments and ketamine anesthesia-skilled doctor.

중국에 있어서 사회체육의 발전동향

임영호,박남환,정명수 조선대학교 스포츠과학연구소 1997 스포츠科學硏究 Vol.8 No.-

상관기 진폭 보상에 따른 판별력 조사

황수용,이상이,김남선 서울産業大學校 1996 논문집 Vol.44 No.1

광 JTC는 실시간 상관 시스템에 응용이 가능하다는 장점에 반하여 위상 혹은 진폭성분만을 별도로 처리하기는 어려운 상태에 있었으나, 최근 POC와 POF에 유사한 상관특성을 나타낼수 있는 광 BPEJTC, HPEJTC등이 제안되면서 위상과 진폭이 별도로 처리될 수 있게 되었다. 그러나, 이러한 시스템들은 위상과 진폭이 상관성능에 어떠한 영향을 미치는재 평가하기는 어려운 상태에 있었다. 따라서, 본 논문에서는 진폭이나 위상 성분의 비중을 변동시키며 상관성능을 분석 할 수 있는 것으로 ACMF를 기초로 하는 JTC 시스템인 ACJTC를 수학적 해석을 통해 비교분석하였다. ACJTC는 ACMF의 특성상 위상과 진폭 성분의 비중을 가변시킬수 있으므로 잡음 및 유사표적에 대하여 우수한 상관 판벽력을 나타내게 된다. 이러한 특성을 조사하기 위해 자연게 배경에 다중 표적 영상을 주기적으로 배치하고 컴퓨터 시뮬레이션하였으며, 광 JTC를 통한 실시간 상관 시스템의 구현 가능성을 제시하였다. The optical JTC system has the advantage of being applied to the real-time correlation system, but it has some difficulties that is amplitude and phase signals cannot be separately processed. Recently to solve those problems the BPEJTC and HPEJTC systems having the same characteristics of that of the POC and POF have been proposed. But there is no quantitive analysis how much the amplitude and phase signals are contributed to the correlation outputs respectively. In this paper, a ACJTC system based on the conventional ACMF is discussed through the mathematical analysis. The good correlation discrimination of the system is also analyzed by changing the relative contribution of the phase and amplitude signals for some similar targets. From the successful computer simulation results on the scenario where three same targets are periodically located on the nature background, the possibility of the high performance real-time correlation system based on the optical ACJTC is suggested.