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Soni,Vaishali Walke,Deepti Joshi,Tanya Sharma,Adesh Shrivastava,Amit Agrawal 대한병리학회 2024 Journal of Pathology and Translational Medicine Vol.58 No.3
Background: Primary brain tumors constitute the leading cause of cancer-related mortality. Among them, adult diffuse gliomas are the most common type, affecting the cerebral hemispheres and displaying a diffuse infiltrative pattern of growth in the surrounding neuropil that accounts for about 80% of all primary intracranial tumors. The hallmark feature of gliomas is blood vessel proliferation, which plays an important role in tumor growth, tumor biological behavior, and disease outcome. High-grade gliomas exhibit increased vascularity, the worst prognosis, and lower survival rates. Several angiogenic receptors and factors are upregulated in glioblastomas and stimulate angiogenesis signaling pathways by means of activating oncogenes and/or down-regulating tumor-suppressor genes. Existing literature has emphasized that different microvascular patterns (MVPs) are displayed in different subtypes of adult diffuse gliomas. Methods: We examined the distribution and biological characteristics of different MVPs in 50 patients with adult diffuse gliomas. Haematoxylin and eosin staining results, along with periodic acid–Schiff and CD34 dual-stained sections, were examined to assess the vascular patterns and correlate with different grades of diffuse glioma. Results: The present observational study on adult diffuse glioma evaluated tumor grade and MVPs. Microvascular sprouting was the most common pattern, while a bizarre pattern (type 2) was associated with the presence of a high-grade glioma. Vascular mimicry was observed in 6% of cases, all of which were grade 4 gliomas. Conclusions: This study supplements the role of neo-angiogenesis and aberrant vasculature patterns in the grading and progression of adult diffuse gliomas, which can be future targets for planning treatment strategies.
Traditional uses, phytochemistry and pharmacology of Bauhinia racemosa Lam - a review
Vishal Soni,Arvind Kumar Jha,Jaya Dwivedi,Priyanka Soni 셀메드 세포교정의약학회 2015 TANG Vol.5 No.4
Bahunia racemosa family, Caesalpiniaceae, is one of the precious resources of the earth. It has played a significant role in human civilization since ancient times. It is tall sized tree growing throughout India, Ceylon, China, and Timor. The different part of this plant contains β-sitosterol and β-amyrin, flavonols (kaempferol and quercetin) and two coumarins (scopoletin and scopolin), tannins etc. Various part of this plant has great pharmacological potential with a great utility and usage as folklore medicine as analgesic, antipyretic, anti-inflammatory, antispasmodic and antimicrobial activity. This review mainly focus on the exclusive review work on the traditional, phytochemical and pharmacological activities of this plant.
Traditional uses, phytochemistry and pharmacological profile of Bambusa arudinacea Retz
Vishal Soni,Arvind Kumar Jha,Jaya Dwivedi,Priyanka Soni 셀메드 세포교정의약학회 2013 셀메드 (CellMed) Vol.3 No.3
Bambusa arundinacea family Graminae, is one of the precious plant resources of the earth. It has played a significant role in human civilization since ancient times. It is tall sized tree growing throughout India, moist parts of India. It also occurs in Sri Lanka, Malaya, Peru and Myanmar. The different parts of this plant contain silica, cholin, betain, cynogenetic glycosides, albuminoids, oxalic acid, reducing sugar, resins, waxes, benzoic acid, arginine, cysteine, histidine, niacin, riboflavin, thiamine, protein, gluteline, contains lysine, methionine, betain, cholin, proteolytic enzyme, nuclease, urease. Various parts of this plant such as leaf, root, shoot and seed possess anti-inflammatory, antiulcer, anti-diabetic, anti-oxidant, anthelmintic, antifertility, antibacterial, insectisidal, antiarthritic, vessele protection etc. This review mainly focuses on the traditional, phytochemical and pharmacological information of Bambusa arundinacea.
Sony Maharjan,박병권,이수인,임융호,이근욱,이영희,권형주 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.2
Colorectal cancer is one of the leading causes of cancer related death due to a poor prognosis. In this study, we investigated the effect of Gomisin G on colon cancer growth and examined the underlying mechanism of action. We found that Gomisin G significantly suppressed the viability and colony formation of LoVo cells. Gomisin G reduced the phosphorylation level of AKT implying that Gomisin G suppressed the PI3K-AKT signaling pathway. Gomisin G also induced apoptosis shown by Annexin V staining and an increased level of cleaved poly-ADP ribose polymerase (PARP) and Caspase-3 proteins. Furthermore, Gomisin G remarkably triggered the accumulation of cells at the sub-G1 phase which represents apoptotic cells. In addition, the level of cyclin D1 and phosphorylated retinoblastoma tumor suppressor protein (Rb) was also reduced by the treatment with Gomisin G thus curtailing cell cycle progression. These findings show the suppressive effect of Gomisin G by inhibiting proliferation and inducing apoptosis in LoVo cells. Taken together, these results suggest Gomisin G could be developed as a potential therapeutic compound against colon cancer.
Race, Reason, and Emotion:Reading Pramoedya Ananta Toer’s House of Glass
Sony Karsono 한국동남아학회 2021 동남아시아연구 Vol.31 No.2
In the early 20th-century Dutch East Indies, through domestic espionage and scholarly research, the colonial state produced strategic knowledge about its Native subjects. The state used such knowledge to keep the Natives under control. House of Glass, the fourth and last novel in Pramoedya Ananta Toer’s “Buru Quartet,” offers a fictionalized historical account of how the domestic spy work and scholarly studies responded to the emergence of Native nationalist movement. This paper examines one product of the colonial state’s knowledge- production activities: the colonial discourse on Natives revolving around the notions of race, reason, and emotion. A critical reading of this discourse suggests that it contains not merely racial prejudices on the part of European colonial masters against Natives but also elements of truth about them. Pramoedya seems to have used the narrator Jacques Pangemanann to draw attention to the troubling weaknesses he saw in Indonesians, both in the colonial era and under the New Order.
Reliability analysis of acyclic transmission network based on minimal cuts using copula in repair
Soni Bisht,S.B Singh 장전수학회 2019 Proceedings of the Jangjeon mathematical society Vol.22 No.3
In the present paper, we have considered acyclic transmis- sion network in which number of nodes are capable of receiving or send- ing a signal to the target nodes. To model the proposed acyclic trans- mission network, the present study combined the concepts of Markov processes and minimal cuts incorporating copula to nd the various re- liability measures. The considered network can have four possible states namely operable, partial failure, critical failure and complete failure. The proposed network can be repaired in two dierent ways. When the network is in critical state it is repaired with general repair, whereas, in complete failure state it is repaired with the help of two dierent repair rates, namely, general and exponential. The general and expo- nential distributions have been incorporated with the application of the Gumbel-Hougaard family of copula. Various reliability characteristics such as transition state probabilities, asymptotic behavior, reliability, mean time to failure and sensitivity of the proposed network has been evaluated with the help of minimal cuts coupling with Markov processes using GumbelHougaard copula, supplementary variable techniques and Laplace transforms.
( Sony Maharjan ),( Byoung Kwon Park ),( Su In Lee ),( Yoonho Lim ),( Keunwook Lee ),( Hyung-joo Kwon ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3
A type of breast cancer with a defect in three molecular markers such as the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor is called triple-negative breast cancer (TNBC). Many patients with TNBC have a lower survival rate than patients with other types due to a poor prognosis. In this study, we confirmed the anti-cancer effect of a natural compound, Gomisin G, in TNBC cancer cells. Treatment with Gomisin G suppressed the viability of two TNBC cell lines, MDA-MB-231 and MDA-MB-468 but not non-TNBC cell lines such as MCF-7, T47D, and ZR75-1. To investigate the molecular mechanism of this activity, we examined the signal transduction pathways after treatment with Gomisin G in MDA-MB-231 cells. Gomisin G did not induce apoptosis but drastically inhibited AKT phosphorylation and reduced the amount of retinoblastoma tumor suppressor protein (Rb) and phosphorylated Rb. Gomisin G induced in a proteasome-dependent manner a decrease in Cyclin D1. Consequently, Gomisin G causes cell cycle arrest in the G1 phase. In contrast, there was no significant change in T47D cells except for a mild decrease in AKT phosphorylation. These results show that Gomisin G has an anti-cancer activity by suppressing proliferation rather than inducing apoptosis in TNBC cells. Our study suggests that Gomisin G could be used as a therapeutic agent in the treatment of TNBC patients.
A weighted Fourier series with signed good kernels
Sony Chan,임경수 대한수학회 2017 대한수학회보 Vol.54 No.3
It is natural to try to find a kernel such that its convolution of integrable functions converges faster than that of the Fej\'er kernel. In this paper, we introduce a weighted Fourier partial sums which are written as the convolution of signed good kernels and prove that the weighted Fourier partial sum converges in $L^2$ much faster than that of the Ces\`aro means. In addition, we present two numerical experiments.