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미세유체채널 내에서 가해진 복합적 자극에 따른 미세아교세포의 활성도 및 운동성 변화 양상에 관한 연구
안송이(Song Ih Ahn),송석현(Sukhyun Song),신현준(Hyun Jun Shin),박진성(Jin-Sung Park),신현정(Jennifer H. Shin) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
In neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, microglia, a type of brain cells, play critical role as immune cells depending on their activation states. Microglia undergo significant changes in their activation states, which determine their functional roles and migration patterns, upon various physicochemical stimulations from the microenvironment of the brain. Moreover, brain cells can be exposed to exogenously imposed physical stimulations from therapeutic treatments. Therefore, it is important to understand how physical cues influence the activation states of microglia. Our ability to regulate the activation state by physical stimulations can provide new insights for pathological outbreaks of such diseases and may lead us to a novel therapeutic tool. To investigate how physical cues influence the activation states of microglia, we developed a microfluidic platform that can apply the combinatorial stimulation of an fluid shear stress and electric field on microglial cells by controlling two directional cues independently.
안송이(Song Ih Ahn),홍정우(Jung Woo Hong),신현정(Jennifer H. Shin) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
Sphingosylphosphoryl choline (SPC) is a bioreactive lipid, present in abnormally high concentrations in pancreatic cancer patients. SPC is known to facilitate cancer metastasis by altering cytokeratin network, enhancing cell migration. In this study we investigated the effects of SPC on cell migration behavior, focusing on the major players in cell migration, actin cytoskeleton structure and cell traction force rather than cytokeratin network. From our preliminary tests of immunofluorescence analysis and traction force microscopy, treatment of SPC induced higher expression of lamellipodia and lower traction force, respectively. These results concur to the fact that SPC enhances cell migration, since motile cells are known to actively express lamellipodia and form weak bindings to the substrate. We suggest that SPC stimulation in pancreatic cancer cells would enhance cell migration by modulating cellular traction force and actin cytoskeletal network, which in turn facilitates metastasis.
미세 유체 장기 칩 내 다공성 막의 기공 크기와 밀도 변화에 따른 막 성능 전산해석
이수미(Sumi Lee),황진율(Jinyul Hwang),안송이(Song Ih Ahn) 대한기계학회 2024 大韓機械學會論文集B Vol.48 No.7
인체 내 조직의 장벽을 모사하는 장기 칩(organ-on-a-chip)은 두 미세 유체 채널층이 장벽 층을 모사하는 다공성 막(porous membrane)으로 분리되어 두 채널층에 배양된 세포 간의 상호작용이 가능하도록 설계된다. 다공성 막의 재료와 구조 특성이 장기 칩 내 미세 유체 환경에 미치는 영향이 존재함에도 불구하고, 그에 대한 분석은 여전히 부족하다. 본 연구에서는 전산해석을 이용해 다공성 막의 구조 매개변수가 장기 칩 내 미세환경에 미치는 영향을 분석하였다. 결과적으로 투과도(solute permeability)와 막 변형을 동시에 최적화하는 적절한 다공성 막을 설계하기 위해 pore diameter와 pore density를 종합적으로 고려해야 함을 확인하였다. 본 연구를 통해 다공성 막의 구조 매개변수를 정밀히 설계하여 장기 칩이 생체조건을 보다 정교하게 모사할 수 있는 가능성을 제시한다. Porous membranes separate two microfluidic channels comprising organ-on-a-chip systems, enabling interaction between cells cultured in both channels. Although it is evident that the material and structural characteristics of porous membranes affect the microfluidic environment in organ-on-a-chip systems, porous membranes have not been studied extensively. Here, we examine the influence of structural parameters of porous membranes on the microenvironment within an organ-on-a-chip system using computational fluid dynamics. Our findings highlight the necessity of a comprehensive consideration of pore diameter and pore density to design an optimal porous membrane that simultaneously enhances solute permeability and deformation. This research suggests the potential for a more accurate design of physiological conditions in organ-on-a-chip systems by precisely adjusting the structural parameters of porous membranes.