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Song, Cheryn,Doo, Chin Kyung,Hong, Jun-Hyuk,Choo, Myung-Soo,Kim, Choung-Soo,Ahn, Hanjong Williams and Wilkins Co 2007 The Journal of urology Vol.178 No.1
<P><B>Purpose</B></P><P>We investigated how the preoperatively estimated integrity of pelvic floor muscles related to the recovery of continence after radical prostatectomy.</P><P><B>Materials and Methods</B></P><P>A total of 94 patients underwent magnetic resonance image of the prostate and urodynamic studies before undergoing radical prostatectomy and evaluation of voiding symptoms before, and 3 and 6 months after surgery. Incontinence was defined as any unwanted urine leakage. On the magnetic resonance image the thickness of the levator ani and pelvic diaphragm, and prostate volume were measured to correlate with continence status.</P><P><B>Results</B></P><P>Incontinence was noted in 41.5% and 15.9% of the patients at 3 and 6 months, respectively. Recovery of continence 3 months after RP was related to the thickness of the pelvic diaphragm on sagittal imaging (p = 0.017), the ratio of the levator ani on the axial image to prostate volume (p = 0.047), functional urethral length (p = 0.007) and incontinence before surgery (p = 0.009). Recovery at 6 months was related to neurovascular bundle sparing (p = 0.013) and marginally to the pelvic diaphragm on sagittal imaging (p = 0.059). On multivariate analysis the pelvic diaphragm on sagittal imaging (HR 2.455, 95% CI 0.894–6.739, p = 0.008) and the ratio of the levator ani on the axial image to prostate volume (HR 1.886, 95% CI 0.952–3.736, p = 0.011) significantly predicted continence at 3 months, while at 6 months only the pelvic diaphragm on sagittal imaging showed a significant relationship (p = 0.024).</P><P><B>Conclusions</B></P><P>Pelvic diaphragm thickness and the ratio of levator ani thickness to prostate volume are independent factors predictive of post-prostatectomy incontinence. Patients with better developed pelvic floor muscles, especially in relation to the size of the prostate, can be expected to achieve earlier recovery of continence after radical prostatectomy.</P>
Song, Cheryn,Lee, Jungmin,Hong, Jun Hyuk,Choo, Myung-Soo,Kim, Choung-Soo,Ahn, Hanjong Blackwell Publishing Ltd 2010 BJU INTERNATIONAL Vol.106 No.5
<P>Study Type – Diagnostic (exploratory cohort)Level of Evidence 2b</P><P>OBJECTIVE</P><P>To investigate and compare changes in the bladder function after radical prostatectomy (RP) and to correlate changes in subjective voiding symptoms with the observed changes in function.</P><P>PATIENTS AND METHODS</P><P>In 72 patients who had RP between 2003 and 2004, we serially evaluated urodynamic studies (UDS) before RP and at 3, 6 and 36 months afterward. The short-form International Continence Society-<I>male</I> symptom questionnaire was also repeated at corresponding periods. Changes in bladder contraction and storage function after RP were compared for changes in subjective symptoms.</P><P>RESULTS</P><P>On serial UDS, there were reductions in maximum cystometric capacity, maximum detrusor pressure and maximum urethral closure pressure (MUCP) at 3 months, after which all remained relatively unchanged. On the questionnaire, the voiding symptom domain score improved (8.04 to 4.82, <I> P</I> < 0.001) while the storage domain score significantly and progressively worsened, beginning from 3 months (2.25 to 3.78, <I> P</I>= 0.04), resulting in an unchanged overall urinary symptom-related quality of life at 3 years. The incidence of detrusor overactivity increased from 37.5% before RP, to 45.8% at 3 months and 51.4% at 3 years. At 3 years, a recurring postvoid residual urine volume was the cause of the deterioration in the voiding symptom domain score, while a prominent reduction in MUCP resulted in a deterioration in the storage symptom score.</P><P>CONCLUSIONS</P><P>There is a reduction in bladder capacity, detrusor and sphincteric activity immediately after RP, stabilizing thereafter but remaining significantly reduced at 3 years. Although voiding symptoms improved in most men, the significant deterioration in storage symptoms, which might be attributed to sphincteric incompetence in addition to increased detrusor overactivity, became a source of overall urinary bother in the long term.</P>
Myungsun Shim,Cheryn Song,Jintaek Park,Minkyu Kang,Moo-Song Lee,Jongwon Kim,Hanjong Ahn 대한비뇨기종양학회 2014 대한비뇨기종양학회지 Vol.12 No.1
Purpose: We aimed to identify the relationship between the serum testosterone (TS) axis and the clinically localized prostate cancer and to evaluate the changes in hormone concentrations after radical prostatectomy (RP). Materials and Methods: Blood samples were drawn from 699 patients with prostate cancer before and after RP, without hormone or radiation therapy, and from 700 age-matched healthy men between 7:00 and 9:00 A.M., and their serum concentrations of total TS and sex hormone-binding globulin (SHBG) were measured. Results: Patients with prostate cancer had lower mean SHBG (55.8±22.0 vs. 61.4±24.2 nmol/L) and higher mean free TS (FT) (7.1±2.5 vs. 6.3±2.6 ng/dl), bioavailable TS (BAT) (158.2±55.2 vs. 138.1±56.5 ng/dl), and free TS index (FTI) (31.3±12.0 vs. 27.1±11.6) than healthy controls (all, p<0.001), while total TS did not differ. Following RP, patients with prostate cancer showed significant increases in SHBG (65.6±26.3 vs. 56.3±21.6 nmol/L) and subsequent decreases in FT (6.4±4.4 vs. 7.2±2.5 ng/dl), BAT (138.2±50.3 vs. 158.7±55.3 ng/dl), and FTI (26.5±11.1 vs. 31.2±11.7) (all, p<0.001), whereas total TS remained unchanged. Preoperative SHBG concentration was significantly lower in patients with pathologic Gleason score (GS) <7 than in those with GS ≥7 (p<0.001). SHBG was an independent predictor of pathologic GS <7 (p=0.003), along with preoperative prostatic specific antigen (PSA) concentration and biopsy GS. Conclusions: Prostate cancer influences the sex hormonal axis, modulating SHBG concentration and increasing the utilization of bioactive TS.
Age at Diagnosis is an Independent Predictor of Small Renal Cell Carcinoma Recurrence-Free Survival
Jeong, In Gab,Yoo, Chang Hee,Song, Kanghyon,Park, Jinsung,Cho, Yong Mee,Song, Cheryn,Hong, Jun Hyuk,Ahn, Hanjong,Kim, Choung-Soo Elsevier 2009 The Journal of urology Vol.182 No.2
<P><B>Purpose</B></P><P>Controversy exists as to the influence of age at diagnosis on prognosis in patients with renal cell carcinoma. We investigated the relationship between age at diagnosis and disease recurrence after surgery in patients with small renal cell carcinoma.</P><P><B>Materials and Methods</B></P><P>Of the 1,196 patients who underwent curative surgery for renal cell carcinoma between 1989 and 2005 at our institution 490 with renal cell carcinoma 4 cm or less were included in our study. Patients were stratified into 3 subgroups according to age at diagnosis, including 40 years or less in 93, 41 to 60 years in 253 and greater than 60 years in 144. Clinical and pathological variables at diagnosis were compared and survival analysis was performed.</P><P><B>Results</B></P><P>A total of 17 patients (3.5%) experienced disease recurrence and 9 (1.8%) died of metastatic renal cell carcinoma during followup. Higher Fuhrman nuclear grade was associated with older age at diagnosis (p = 0.001). Histological subtypes were associated with age categories (p = 0.016). The overall recurrence-free survival rate was 97.2% and 92.4% at 5 and 10 years, respectively. The 10-year recurrence-free survival rate was 100% for patients 40 years old or younger, 95.7% for those 41 to 60 years old and 79.0% for those older than 60 years (p = 0.002). Multivariate analysis revealed that age at diagnosis and Fuhrman grade independently predicted recurrence-free survival (p = 0.027 and <0.001, respectively).</P><P><B>Conclusions</B></P><P>Age at diagnosis was an independent predictor of recurrence-free survival after curative surgical treatment in patients with small renal cell carcinoma. Our results suggest that older patients with small renal cell carcinoma should be more closely followed after surgery than younger patients.</P>
Yoo, Changhee,Oh, Cheol Young,Cho, Jin Seon,Song, Cheryn,Seo, Seong Il,Ahn, Hanjong,Hwang, Tae-Kon,Cheon, Jun,Lee, Kang Hyun,Kwon, Tae Gyun,Jung, Tae Young,Chung, Moon Kee,Lee, Sang Eun,Lee, Hyun Moo The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.4
<P>We investigated the clinical significance of large difference (≥ 2 points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups: A (decreased in pGS ≥ 2, n = 30), B (changed in pGS ≤ 1, n = 1,361; control group), and C (increased in pGS ≥ 2, n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max%) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max% were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (<I>P</I> = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.</P>
Kim, Yi Rang,Lee, Jae Lyun,You, Dalsan,Jeong, In Gab,Song, Cheryn,Hong, Bumsik,Hong, Jun Hyuk,Ahn, Hanjong Springer 2015 Cancer chemotherapy and pharmacology Vol.76 No.1
<P>Cisplatin-based chemotherapies are standard treatment regimens of advanced urothelial cell carcinoma. But a significant proportion of patients are unsuitable for cisplatin due to impaired renal function. Carboplatin-based regimens such as gemcitabine and carboplatin regimen (GCb) were applied due to less nephrotoxicity and side effects in these patients. However, it is known that clinical outcome of carboplatin-based regimens was unsatisfactory compared to cisplatin-based regimens. We compared the nephrotoxicity and response to treatment between GCb and gemcitabine plus split-dose cisplatin regimen (GC-S).</P>
Kang, Minyong,Park, Jae Young,Jeong, Chang Wook,Hwang, Eu Chang,Song, Cheryn,Hong, Sung-Hoo,Kwak, Cheol,Chung, Jinsoo,Sung, Hyun Hwan,Jeon, Hwang Gyun,Jeong, Byong Chang,Park, Se Hoon,Jeon, Seong Soo Elsevier 2018 The Journal of urology Vol.200 No.5
<P>Conclusions: Conditional survival improved with time after initial tyrosine kinase inhibitor treatment in patients with metastatic renal cell carcinoma. Our study offers valuable information for practical survival estimations and relevant prognosticators in patients with metastatic renal cell carcinoma who receive first line tyrosine kinase inhibitor.</P>