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Genome-Wide Association Study of Bone Mineral Density in Korean Men
Bae, Ye Seul,Im, Sun-Wha,Kang, Mi So,Kim, Jin Hee,Lee, Soon Hang,Cho, Be Long,Park, Jin Ho,Nam, You-Seon,Son, Ho-Young,Yang, San Deok,Sung, Joohon,Oh, Kwang Ho,Yun, Jae Moon,Kim, Jong Il Korea Genome Organization 2016 Genomics & informatics Vol.14 No.2
Osteoporosis is a medical condition of global concern, with increasing incidence in both sexes. Bone mineral density (BMD), a highly heritable trait, has been proven a useful diagnostic factor in predicting fracture. Because medical information is lacking about male osteoporotic genetics, we conducted a genome-wide association study of BMD in Korean men. With 1,176 participants, we analyzed 4,414,664 single nucleotide polymorphisms (SNPs) after genomic imputation, and identified five SNPs and three loci correlated with bone density and strength. Multivariate linear regression models were applied to adjust for age and body mass index interference. Rs17124500 ($p=6.42{\times}10^{-7}$), rs34594869 ($p=6.53{\times}10^{-7}$) and rs17124504 ($p=6.53{\times}10^{-7}$) in 14q31.3 and rs140155614 ($p=8.64{\times}10^{-7}$) in 15q25.1 were significantly associated with lumbar spine BMD (LS-BMD), while rs111822233 ($p=6.35{\times}10^{-7}$) was linked with the femur total BMD (FT-BMD). Additionally, we analyzed the relationship between BMD and five genes previously identified in Korean men. Rs61382873 (p = 0.0009) in LRP5, rs9567003 (p = 0.0033) in TNFSF11 and rs9935828 (p = 0.0248) in FOXL1 were observed for LS-BMD. Furthermore, rs33997547 (p = 0.0057) in ZBTB and rs1664496 (p = 0.0012) in MEF2C were found to influence FT-BMD and rs61769193 (p = 0.0114) in ZBTB to influence femur neck BMD. We identified five SNPs and three genomic regions, associated with BMD. The significance of our results lies in the discovery of new loci, while also affirming a previously significant locus, as potential osteoporotic factors in the Korean male population.
Hwang, Dukhyun,Son, Byeng-Wha,Shin, Pyung-Gyun,Choi, Jae-Sue,Seo, Yong-Bae,Kim, Gun-Do Pharmaceutical Society of Great Britain 2015 Journal of pharmacy and pharmacology Vol.67 No.9
<P>ObjectivesThe purpose of this study is to investigate anti-inflammatory effects of toluhydroquinone in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. MethodsToluhydroquinone was purified from a fungal strain, Aspergillus sp. We investigated that levels of nitric oxide (NO) using Griess reagent, production of prostaglandin E-2 (PGE(2)) and pro-inflammatory cytokines using ELISA assay. We conducted Western blot analysis to investigate regulatory effects of toluhydroquinone on expression of inducible nitric oxide synthase (iNOS), cyclooxyganse-2 (COX-2), nuclear factor-B (NF-B), Akt and mitogen-activated protein kinases (MAPKs) in LPS-stimulated RAW264.7 cells. The translocation of NF-B was detected by immunofluorescence staining. Key findingsToluhydroquinone inhibited production of NO and PGE(2) via suppressing protein expression of iNOS and COX-2, respectively. Secretion and expression of inflammatory cytokines were down-regulated by toluhydroquinone as well. Toluhydroquinone reduced phosphorylation of Akt, NF-B and MAPKs. Moreover, toluhydroquinone inhibited translocation of NF-B from the cytosol into the nucleus. ConclusionsWe revealed that inhibitory effects of toluhydroquinone on expression of inflammatory mediators are induced through inactivation of Akt, NF-B and MAPKs. Thus, our results suggest that toluhydroquinone may be used for a potential anti-inflammatory reagent.</P>
기술보고 : 특허 분석을 통한 산사태재해 관련 기술개발 전략
배기수 ( Khee Su Bae ),송영화 ( Yeong Wha Sawng ),채병곤 ( Byung Gon Chae ),최정해 ( Junghae Choi ),손정근 ( Jeong Keun Son ) 대한지질공학회 2014 지질공학 Vol.24 No.4
본 연구는 자연사면 산사태를 대상으로 한 실시간 모니터링 기술과 이를 이용한 산사태 탐지기술에 대해 기존 특허를 체계적으로 분석하였다. 특허분석의 목적은 산사태재해 관련 기술 동향을 파악하고 이를 토대로 보다 진보된 기술을 개발하는데 활용하기 위한 것이다. 이 분석에서는 산사태 모니터링 및 탐지기술에 관련된 특허를 한국, 미국, 일본, 중국(홍콩), 유럽, 대만 등 총 6개의 국가를 대상으로 하여 주요 키워드 별로 검색하였다. 대분류와 소분류로 나누어 각각 기술 분류에 따라 연도별, 국가별, 출원인별 분석을 실시하였으며, 분석결과에 따라 국가별 요소기술 및 유망기술에 대한 포트폴리오를 도출하였다. 본 연구의 분석결과는 향후 산사태 모니터링 및 탐지기술 분야에 있어서 더욱 효과적인 연구 개발 방향을 수립하고, 기존의 기술과 차별화된 연구 성과를 이끌어 내는데 도움이 될 수 있는 기초 자료가 될 수 있을 것으로 사료된다. This study analyzed existing patents related to real-time monitoring and detection technology for landslides on natural terrain. The purpose of patent analysis is to understand landslide hazard technology trends and to develop new advanced technology. This study searched patent data using key words related to landslide monitoring and detection in Korea, the USA, Japan, China (Hong Kong), Europe, and Taiwan. The patents were divided into five main categories and five to seven subcategories in each main category and analyzed by year, country, and applicants. The results were utilized to derive a portfolio of promising technologies for each country. The analysis results will also contribute to the development of more effective research strategies and to categorize research findings from previous studies on landslide hazards.
박영숙(Young Sook Park),손숙미(Sook Mee Son),임화재(Wha Jae Lim),김숙배(Sook Bae Kim),정연선(Yeon Sun Chung) 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.1
This study was performed to understand recognition and behaviors related to sodium intake of Korean adults. The data were collected from subjects including 267 male and 285 female adults in nationwide and compared by gender and by age. We found that the male group showed significantly higher smoking, alcohol drinking, and exercise does the female group. The older group (40 to 59 years) revealed significantly higher exercise and lower alcohol drinking; however general disease and hypertension prevalence, diet therapy practice, and meditation for hypertension were higher. Recognizing sodium levels of foods containing high-sodium, and sodium-nutriture labels when purchasing foods, and knowing differences between salt and sodium of the male group or recognizing sodium levels of foods containing high-sodium of the older group was worse than the other. Among the 32 food behaviors, only 12 were identified as significantly correlated to sodium intake levels including behaviors of preferring Chinese and Japanese foods to Western foods, preferring kimchi to raw vegetables, completely consuming soup, stew, noodle liquid, liking of dried fish and salted mackerel, frequent eat-outs or delivered foods, and so forth. There were significant differences between gender or age groups in terms of sodium intake-increasing behaviors; the male group showed higher behaviors of preferring salty taste and eating all broths. And the older group revealed higher behavior of adding table salt as well as the previous two, however, the younger group showed more behaviors of eat-outs or delivered foods and not the liquid of kimchi. (Korean J Community Nutrition 13(1) : 1~12, 2008)