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- 저자 : Somrit, Mahattanobon (검색결과 3 건)
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Cosmetic Outcomes and Quality of Life in Thai Women Post Breast Conserving Therapy for Breast Cancer
Thanarpan, Peerawong,Somrit, Mahattanobon,Rungarun, Jiratrachu,Paytai, Rordlamool,Duangjai, Sangtawan,Chanon, Kongkamol,Puttisak, Puttawibul Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11
Purpose: To evaluate the correlation between cosmetic outcome (CO), body image, and quality of life in post breast-conserving therapy (BCT) women. Materials and Methods: This cross-sectional study concerned one-year post-completed BCT Thai women. The data included subjective and objective CO with a questionnaire covering demographic and clinical data, anti-hormonal treatment status, Eastern Cooperative Oncology Group (ECOG) performance status, Self-Reported Cosmetic Outcomes (SRCO), Self-Reported Breast Symmetry (SRBS), Body Image Scale (BIS), and the Functional Assessment of Cancer Therapy with Breast Cancer subscale (FACT-B). Participants had breast photographs taken for the evaluation of objective cosmetic outcome (OCO) after breast cancer conservation treatment. The relationship between CO and FACT-B was tested using Spearman's rank correlation Results: A total 127 participants volunteered for the study. The participant characteristics were age 52(${\pm}9$), Buddhist 87%, married 65%, body mass index 25.0(${\pm}4.6$), breast cup size A-C 91%, college educated 60%, employed 66%, ECOG 0-1 95%, tumor size less than or equal to 2 cm 55%, no lymph node metastasis 98%, and taking tamoxifen 57%. Two percent of the participants regretted their decision to undergo BCT. The SRCO was excellent in 2%, good in 68%, fair in 30%, and poor in 0%. For SRBS, rates were 17%, 58%, 24% and 1% for excellent, good, fair and poor cosmetic outcomes, respectively. The BCCT scores were excellent 24%, good 39%, fair 32%, and poor 6%. The median total QOL score of the participants was 130 (93-144). There was no significant correlation between CO and FACT-B scores. Conclusions: The significance of CO for FACT-B in Thai women with breast cancer could not be assessed in detail because of a very low level of correlation. The results may be due to the effects of cultural background.
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Breast Conserving Therapy and Quality of Life in Thai Females: a Mixed Methods Study
Peerawong, Thanarpan,Phenwan, Tharin,Supanitwatthana, Sojirat,Mahattanobon, Somrit,Kongkamol, Chanon Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
Background: To explore factors that influence quality of life (QOL) in patients receiving breast conserving therapy (BCT). Materials and Methods: In this sequential mixed methods study, 118 women from Songklanagarind Hospital were included. We used participants' characteristics, Body Image Scale (BIS), and Functional Assessment of Cancer Therapy with the Breast Cancer Subscale (FACT-B) for analysis. The BIS transformed into presence of body image disturbance (BID). Factors that influenced QOL were determined by stepwise multiple linear regression. Forty-one participants were selected for qualitative analysis. Our female researcher performed the semi-structured interviews with questions based on the symbolic interaction theory. Final codes were analysed using thematic analysis along with investigator triangulation methods. Results: Ninety percent had early stage breast cancer with post-completed BCT, for an average of 2.7 years. The median BIS score and FACT-B score were 2 (IQR=10) and 130 (IQR=39). In the regression analysis, an age of more than 50 years and BID were significant factors. As for the value of conserved breasts, two themes emerged: a conserved breast is an essential part of a participant's life and also the representation of her womanhood; the importance of a breast is related to age. Conclusions: Body image influenced QOL in post BCT participants. The conserved breasts also lead to positive and better impact on their body image as an essential part of their life.
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Stochastic Modeling of External Electric Field Effect on Escherichia Coli Min Protein Dynamics
Charin MODCHANG,Wannapong TRIAMPO,Paisan KANTHANG,Udorn JUNTHORN,Somrit UNAI,Waipot NGAMSAAD,Narin NUTTAVUT,Darapond TRIAMPO,Yongwirnon LENBURY 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.2
Cel division in Escherichia coli and other rod-shaped bacteria depends on the precise place- ment of a division septum at the cel center. The MinCDE system consisting of thre proteins, MinC, MinD, and MinE, controls acurate cel division at the center of the cel through pole-to- pole oscilation. With simplifying asumptions and relying on a deterministic model, we present a one-dimensional stochastic model that describes the effects of an external electric field on the MinCDE system. Computer simulations were performed to investigate the response of the oscila- tory dynamics to various strengths of the electric field and to the total number of Min proteins. A sufficient electric field strength was capable of interfering with MinCDE dynamics with posible changes to the cel division proces. Interestingly, effects of an electric field were found not to depend on the total number of Min proteins. The noise involved shifted the corect trend of Min proteins behavior. However, as a consequence of the robustnes of the dynamics, the oscilatory patern of the proteins stil existed even though the number of Min proteins was relatively low. When considering the corelations betwen the local and the global minimum (maximum) of MinD (MinE), the results suggest that using a high enough Min protein concentration wil reduce the localminimum(maximum)effect, which is related to the probability of polar division in each single oscilator cycle. Although this model is simple and neglects some complex mechanisms concerning protein oscilation in corelation with celdivision, it has ben demonstratedto be goodenough for positioning of the dividing site. Nevertheles, more experimental and theoretical studies are neded to provide a more realistic (but of course more complicated) model of bacterial cel division.
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