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- 저자 : Siyu LU (검색결과 3 건)
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Yang, Lu,Li, Ning,Wang, Siyu,Kong, Yanan,Tang, Hailin,Xie, Xinhua,Xie, Xiaoming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Background: Since inconsistent results have been reported regarding the relation between the matrix metalloproteinase-2 (MMP-2) -1306C>T polymorphism and susceptibility for breast cancer, we performed a meta-analysis to investigate the issue. Materials and Methods: An internet search of PubMed and EMBASE was performed to identify eligible studies. Pooled odds ratios (ORs) with their corresponding confidence intervals (CIs) were calculated to evaluate any association between MMP-2 -1306C>T polymorphism and breast cancer susceptibility. Results: Nine case-control studies were included in the meta-analysis, involving 9,858 cases and 10,871 controls. Overall, there was no evidence of any association between the MMP-2 -1306C>T polymorphism and breast cancer susceptibility in different genetic models (T-allele vs C-allele: OR=0.95, 95%CI, 0.82-1.10, p=0.49; TT vs CC: OR=1.03, 95%CI, 0.90-1.19, p=0.66; TT+TC vs CC: OR=0.93, 95%CI, 0.78-1.10, p=0.38; TT vs TC+CC: OR=1.02, 95%CI, 0.89-1.17, p=0.77). In the subgroup analysis by ethnicity, CC was associated with a significant increase in breast susceptibility among Latin-Americans in the dominant model (OR=0.61, 95%CI, 0.40-0.93, p=0.02), but the association disappeared in other models. No significant association was observed among Europeans, East Asians and others in different genetic models. In the subgroup analysis by their source of controls, no significant association between MMP-2 -1306C>T polymorphism and breast cancer susceptibility was noted among population-based studies and hospital-based studies in different genetic models. Conclusions: The results of this meta-analysis suggest that MMP-2 -1306C>T polymorphism is not associated with breast cancer susceptibility, although the association among Latin-Americans in the dominant model was significant.
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Jinkun Yang,Weilu Li,Siyu Gao,Jinliang Zhang,Yi Zhang,Jiawei Lu 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.5
Reservoirs in the Weicheng Oilfield, which occur in Paleogene Shahejie Formation Member 4 (Es4), were formed during the initial and strongly rifting stage of the Dongpu Depression. The geometry and distribution of sands of different types have controlled the heterogeneity of the reservoirs and have resulted in exploration challenges and relatively low recoveries. Based on various static and dynamic geological data including drilling, logging, seismic and production data, the microfacies features and distribution of Es4 were analyzed. Geostatistical three-dimensional (3-D) models and an integrated numerical simulation were constructed to quantify the geometry, spatial distribution and continuity of the reservoir sands and to predict the remaining oil distribution rules. Two depositional systems were recognized in Es4: terminal fans deposits in the lower part and partial shallow-lake deposits in the upper part. The three-dimensional geological model provided insights into the external and internal geometries, distributions and physical properties of the reservoir units. A sedimentary and connectivity feature analysis suggested four types of flow units: Type I units, which are primary sands of distributary channels and bars; Type II units, which are primary sands of proximal overbank and beaches; Type III units, which are sands of distal overbank; and Type IV units, which are mud flats and inter-beach-bar. The numerical simulation reproduced the changing process of the remaining oil, and the areas that have both high remaining oil saturations and reserve abundance, which are controlled by micro-facies and influenced by the structural trend and injection-production relations, comprise the key potential reservoirs: the sand pinch-out area, the imperfect pattern area and structural highs in Type I units and most of the areas in Type II units.
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