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양시원(Siwon Yang),정승채(Seungchai Jung),안철주(Chulju Ahn),박희호(Heeho Park),김기태(Kitae Kim),유경원(Gyongwon Ryu),김용련(Yeongryeon Kim) 한국추진공학회 2016 한국추진공학회 학술대회논문집 Vol.2016 No.5
최근 항공용 가스터빈 연소기 설계는 공기 유입조건(유량, 온도, 압력 등) 변화에 따른 화염안정성 증대, 연소실의 수명 확보, 연소기 출구온도 유지 및 오염물질 저감 등을 목표로 한다. 이러한 연소기의 성능을 운용조건에 맞춰 고압 연소시험을 통하여 검증하는 것은 많은 비용과 시간이 소요되어 제한이 따른다. 최근에는 구성품의 조합 변경이나 국부적인 설계변경이 연소기 성능에 미치는 영향을 파악하고자 CFD(Computational Fluid Dynamics) 해석을 통한 엔진 운용 조건별 연소특성 및 연소기 내부 구조물의 물리량 등을 예측하고 있다. 이러한 수치해석 결과로 설계변경에 따른 영향성 평가가 가능하며 개발비용의 절감과 납기 단축이 가능하다. 본 연구에서는 3차원 전산유체해석 상용 코드인 ANSYS FLUENT 15.0을 이용하여 연소기 설계점에서 스월러 형상에 따른 화염의 형상 및 구조물의 온도분포를 계산하였으며, 이를 바탕으로 향후 설계 개선방향을 검토하였다.
Kim, Ji Won,Ryu, Sung Ha,Kim, Siwon,Lee, Hae Won,Lim, Mi-sun,Seong, Sook Jin,Kim, Suhkmann,Yoon, Young-Ran,Kim, Kyu-Bong American Chemical Society 2013 ANALYTICAL CHEMISTRY - Vol.85 No.23
<P>Drug-induced liver injury (DILI) is currently an increasingly relevant health issue. However, available biomarkers do not reliably detect or quantify DILI risk. Therefore, the purpose of this study was to comparatively evaluate plasma and urinary biomarkers obtained from humans treated with acetaminophen (APAP) using a metabolomics approach and a proton nuclear magnetic resonance (NMR) platform. APAP (3 g/day, two 500 mg tablets every 8 h) was administered to 20 healthy Korean males (age, 20–29 years) for 7 days. Urine was collected daily before and during dosing and 6 days after the final dose. NMR spectra of these urine samples were analyzed using principal component analysis (PCA) and partial least-squares-discrimination analysis. Although the activities of aspartate aminotransferase and lactate dehydrogenase were significantly increased 7 days post-APAP treatment, serum biochemical parameters of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, γ-glutamyl transpeptidase, and lactate dehydrogenase were within normal range of hepatic function. However, urine and plasma <SUP>1</SUP>H NMR spectroscopy revealed different clustering between predosing and after APAP treatment for global metabolomic profiling through PCA. Urinary endogenous metabolites of trimethylamine-N-oxide, citrate, 3-chlorotyrosine, phenylalanine, glycine, hippurate, and glutarate as well as plasma endogenous metabolites such as lactate, glucose, 3-hydroxyisovalerate, isoleucine, acetylglycine, acetone, acetate, glutamine, ethanol, and isobutyrate responded significantly to APAP dosing in humans. Urinary and plasma endogenous metabolites were more sensitive than serum biochemical parameters. These results might be applied to predict or screen potential hepatotoxicity caused by other drugs using urinary and plasma <SUP>1</SUP>H NMR analyses.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2013/ancham.2013.85.issue-23/ac402390q/production/images/medium/ac-2013-02390q_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac402390q'>ACS Electronic Supporting Info</A></P>
( Ji Won Kim ),( Sung Ha Ryu ),( Siwon Kim ),( Hae Won Lee ),( Mi Sun Lim ),( Sook Jin Seong ),( Suhkmann Kim ),( Young Ran Yoon ),( Kyu Bong Kim ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Drug-induced liver injury (DILI) is currently an increasingly relevant health issue. However, available biomarkers do not reliably detect or quantify DILI risk. Therefore, the purpose of this study was to comparatively evaluate plasma and urinary biomarkers obtained from humans treated with acetaminophen (APAP) using a metabolomics approach and a proton nuclear magnetic resonance (NMR) platform. APAP (3 g/day, two 500 mg tablets every 8 h) was administered to 20 healthy Korean males (age, 20-29 years) for 7 days. Urine was collected daily before and during dosing and 6 days after the final dose. NMR spectra of these urine samples were analyzed using principal component analysis (PCA) and partial least-squares-discrimination analysis. Although the activities of aspartate aminotransferase and lactate dehydrogenase were significantly increased 7 days post-APAP treatment, serum biochemical parameters of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, γ-glutamyl transpeptidase, and lactate dehydrogenase were within normal range of hepatic function. However, urine and plasma (1)H NMR spectroscopy revealed different clustering between predosing and after APAP treatment for global metabolomic profiling through PCA. Urinary endogenous metabolites of trimethylamine-N-oxide, citrate, 3-chlorotyrosine, phenylalanine, glycine, hippurate, and glutarate as well as plasma endogenous metabolites such as lactate, glucose, 3-hydroxyisovalerate, isoleucine, acetylglycine, acetone, acetate, glutamine, ethanol, and isobutyrate responded significantly to APAP dosing in humans. Urinary and plasma endogenous metabolites were more sensitive than serum biochemical parameters. These results might be applied to predict or screen potential hepatotoxicity caused by other drugs using urinary and plasma (1)H NMR analyses.
NS3K : A 3nm Nanosheet FET Library for VLSI Prediction in Advanced Nodes
Taehak Kim,Jaehoon Jeong,Seungmin Woo,Jeonggyu Yang,Hyunwoo Kim,Ahyeon Nam,Changdong Lee,Jinmin Seo,Minji Kim,Siwon Ryu,Yoonju Oh,Taigon Song 대한전자공학회 2021 대한전자공학회 학술대회 Vol.2021 No.6
Nanosheet FETs (NSFETs) are expected as future devices that replace FinFETs beyond the 5nm node. Despite the importance of the devices, few studies report the impact of NSFETs in the full-chip level. Therefore, this paper presents NS3K, the first 3nm NSFET library, and presents the results in a full-chip scale. Based on our results, 3nm NSFET reduces power by -27.4%, total wirelength by -25.8%, number of cells by -8.5%, and area by -47.6% over 5nm FinFET, respectively, due to better devices and interconnect scaling. However, careful device/layout designs followed by routing-resource considering standard cells are required to maximize the advantages of 3nm technology.