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Novel quinolone-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping
Da-Sol Lee,Sijoon Lee,Kyung-ku Kang,Soo-eun Sung,Kil Soo Kim,Ghilsoo Nam,Yong Hyun Jeon 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects. In vivo fluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, without in vivo toxicity, which was consistent with the findings of ex vivo imaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging application.
Atobuddy : 아토피 환자를 위한 습관 관리 스마트워치 어플리케이션
김시준(Sijoon Kim),이수빈(Subin Lee),정인영(Inyoung Chung),최용순(Yongsoon Choi) 한국HCI학회 2022 한국HCI학회 학술대회 Vol.2022 No.2
아토피 환자는 가려움으로 인해 극심한 스트레스를 받게 되나, 긁는 행동으로 인해 상처가 발생했을 시 2차 감염의 위험에 노출되기 때문에 의식적으로 긁는 행위를 인지하고 긁지 않으려는 심리적 노력이 필요하다. 또한 아토피가 발병하였을 때의 습도, 온도, 심박수 등 신체와 외부 환경 데이터를 수집하고 스마트폰으로 공유할 수 있다면, 전문의와 상담 시 보다 정확한 진단을 받을 가능성이 높아질 것이다. 따라서, 본 프로젝트는 아토피 환자의 무의식적으로 긁는 행동을 방지할 수 있는 솔루션, 그리고 긁는 행위를 시작했을 시의 생체 데이터를 수집하여 공유할 수 있는 스마트워치 어플 Atobuddy를 기획 및 프로토타입핑하였다.
Dopamine D3 receptor-modulated neuroprotective effects of lisuride
Kim, Munki,Lee, Sijoon,Cho, Jeahyeon,Kim, Gonsup,Won, Chungkil Elsevier 2017 NEUROPHARMACOLOGY - Vol.117 No.-
<P><B>Abstract</B></P> <P>Dopamine (DA) contributes to the regulation of voluntary movement, and a deficiency in DAergic neurons leads to movement disorders. The objective of this study was to examine the neuroprotective effect of DA D2-like receptor agonist, lisuride, and the role of DA receptors in this protection. Treatment with lisuride alleviated loss of tyrosine hydroxylase (TH) both direct and intraperitoneal injection in 6-hydroxydopamine (6-OHDA) mouse model. Similar results were obtained in primary neuronal cultures treated with lisuride. Lisuride protected TH expression against 6-OHDA-induced cytotoxicity in a concentration-dependent manner. Then, we evaluated the role of DA D2 and D3 receptor in neuroprotective effect of lisuride. Treatment of neuronal cultures with L-741,626, a DA D2 receptor-selective antagonist, did not alter neuroprotective effect of lisuride. However, protective effect of lisuride on TH expression was abolished when cells were treated with GR103691, a D3 receptor selective antagonist. Furthermore, whether lisuride can alleviate mitochondrial damage of DAergic neurons induced by 6-OHDA, we investigated the expression of the mitochondrial regulatory protein, paraplegin, and changes in mitochondria morphology. Treatment with lisuride countered a 6-OHDA-induced reduction in paraplegin and TH expression, and co-treatment with GR103691 blocked this effect of lisuride. Transmission electron microscopy confirmed the lisuride mitigation of 6-OHDA-induced damage to the mitochondrial membrane and cristae. These results suggest that the DA D3 receptor mediates the neuroprotective effects of lisuride by preventing mitochondrial damage.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The dopamine D2-like receptor agonist lisuride has neuroprotective effects. </LI> <LI> Lisuride injected into the mouse substantia nigra countered 6-OHDA neurotoxicity. </LI> <LI> Lisuride prevented 6-OHDA-induced damage in neuronal mitochondria. </LI> <LI> Lisuride's neuroprotective actions were blocked by a D3 receptor antagonist. </LI> <LI> The D3 receptor mediates lisuride-induced neuroprotection in dopaminergic neurons. </LI> </UL> </P>
Cho, Gyuhyen,Kim, Munki,Lee, Sijoon,Kim, Chongsup,Won, Chungkil The Korean Society of Developmental Biology 2016 발생과 생식 Vol.20 No.4
The purpose of the present study was to investigate the morphological characteristics of the developing vallate papillae (VP) of Korean native goats using scanning electron microscopy. In prenatal development of the VP, primordia of the VP were observed and the moat was shallowly spread in 60-day-old fetuses. The moat of the vallate papillae was shallowly spread and still undifferentiated in 90-day-old fetuses. The trench wall of the moat of the VP was well developed in 120-day- old fetuses. In neonates, the moat of the VP was more widely and deeply engraved and VP were developed as completely as those of adults. In postnatal development, VP were observed to have continually increased in size with slight morphological changes until 90-days after birth. Taste pores of the VP were shaped like flower leaves in 120-days after birth. The microridges and microplicaes were well developed on the epithelial surface of the VP in goats ranging from 120-day-old fetuses to 120-day-old postnatal animals. These results suppose that the sensing ability for gestation of VP was already well developed by the time of its birth and VP were differentiated into a variety of different shape and size during development.
Gyuhyen Cho,Munki Kim,Sijoon Lee,Chongsup Kim,Chungkil Won 한국발생생물학회 2016 발생과 생식 Vol.20 No.4
The purpose of the present study was to investigate the morphological characteristics of the developing vallate papillae (VP) of Korean native goats using scanning electron microscopy. In prenatal development of the VP, primordia of the VP were observed and the moat was shallowly spread in 60-day-old fetuses. The moat of the vallate papillae was shallowly spread and still undifferentiated in 90-day-old fetuses. The trench wall of the moat of the VP was well developed in 120-dayold fetuses. In neonates, the moat of the VP was more widely and deeply engraved and VP were developed as completely as those of adults. In postnatal development, VP were observed to have continually increased in size with slight morphological changes until 90-days after birth. Taste pores of the VP were shaped like flower leaves in 120-days after birth. The microridges and microplicaes were well developed on the epithelial surface of the VP in goats ranging from 120-day-old fetuses to 120-day-old postnatal animals. These results suppose that the sensing ability for gestation of VP was already well developed by the time of its birth and VP were differentiated into a variety of different shape and size during development.