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CANu1, a novel nucleolar protein, accumulated on centromere in response to DNA damage
Sihn, Choong-Ryoul,Lee, Yeon-Su,Jeong, Jin-Sook,Park, Kyunghee,Kim, Sang Hoon Blackwell Publishing Inc 2008 Genes to cells Vol.13 No.8
<P>Single nucleotide polymorphism is known to be an ideal marker to detect human diseases. We isolated a novel human gene, to be called as <I>CANu1</I>, by the large-scale genome-wide association analysis to screen specific Single nucleotide polymorphisms in colon cancer. It is mapped to chromosome 14q11.2 and its transcript contains a 948-nt open reading frame encoding a protein of 315 aa. Here, we observed that green fluorescence protein (GFP)-fused CANu1 protein was localized to nucleoli and the C-termini of CANu1 protein were essential for its localization. Moreover, the silencing of the <I>CANu1</I> gene by siRNA caused ribosomal stress leading to G1 cell cycle arrest, the induction of p53 protein, and the translocation of B23 protein. In addition, CANu1 protein was translocated from nucleolus to nuclear foci in response to UV damage. Interestingly, the mobility of a GFP-CANu1 protein in the UV damaged cells was two times faster than non-irradiated cells. Taken together, we report that a novel nucleolar protein, CANu1, is essential to maintain ribosomal structure and responsive upon UV damage.</P>
Sihn, Y.,Yun, J. I.,Lee, W. Springer Science + Business Media 2016 JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY Vol.308 No.2
<P>Spectroscopic characteristics of aqueous uranium(VI) (U(VI)) (0.01-1 mu Ie) and its quantification procedure in the presence of Fe(II) (a parts per thousand currency sign0.09 mM) have been developed at pH 7 using TRLFS. The measured fluorescence properties of U(VI) in the phosphate solutions showed the co-presence of UO2HPO4 (aq) and The fluorescence signals of each species were remarkably quenched following dominantly static quenching process via the formation of non-fluorescent complexes. An empirical equation correcting the quenched fluorescence intensity was developed and the corrected values of quenched U(VI) intensity showed a consistency (a parts per thousand yen93.39 +/- A 2.27 %) with the measured uranium concentration by ICP-MS. We firstly confirmed that aqueous U(VI) quantification by TRLFS can be significantly interrupted by Fe(II) quenching via dominantly a static quenching process. The novel analytical procedure for correcting quenched fluorescence intensity (concentration) of U(VI) was developed based on the relationship of the quenched intensity and Fe(II) concentration at neutral pH.</P>