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Micro-groove patterned PCL patches with DOPA for rat Achilles tendon regeneration
Sihyeon Park,이민석,Jin Jeon,Juhan Lim,조현철,Suk Ho Bhang,Hee Seok Yang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
Achilles tendon regeneration using current tissue engineering techniques requires morphometricallymimetic tendon biomaterials to attain the required microstructural tendon tissue and to achieve the necessarymechanical properties. In this study, we used nano- (400 nm) and micro-groove (5000 nm) patternedpolycaprolactone patches (PCL-400, PCL-5000), which offer adequate elastic modulus andbiocompatibility. The PCL patches were fabricated via capillary force lithography and were surface modifiedwith 3,4-dihydroxy-L-phenylalanine (DOPA) for increased hydrophilicity. We hypothesized that theresulting biologically surface-modified elastic groove patterned patches would enhance the cell behaviorsin vitro and the rat Achilles tendon regeneration in vivo. The micro-groove patterned PCL patcheswith DOPA coating (DOPA-PCL-5000) exhibited excellent cell elongation, tenogenic differentiation andYAP expression of the mesenchymal stem cells in our in vitro study and these results were further confirmedby application to the rat Achilles tendon rupture model in our in vivo study. DOPA-PCL-5000induced dramatic regeneration of rat Achilles tendon compared to the other groups, which was furtherconfirmed by the Achilles functional index and histological analysis at 8 weeks. In conclusion, DOPAPCL-5000 can be used not only for damaged Achilles tendon, but also for various functional tendon regenerationtechniques such as rotator cuff, patellar tendon, and flexor tendon.
The Effect of Everyday Creativity and Communication Ability on Self-Leadership in Nursing Students
SiHyeon Park,MyungHoon Kim,GaRam Park,SeungWon Shin,SuIn Lee,SooJin Chae,TaeKyung Kwak,BonJin Koo 한국성인간호학회 2021 성인간호학회 학술대회 Vol.2021 No.8
Aim(s): Recently, as the importance of providing medical information to patients and guaranteeing their rights is emphasized, autonomous leadership development of medical staff is emphasized in providing quality medical services. In particular, daily creativity and appropriate and efficient communication skills, which are concepts that improve self-actualization and adaptability in new and unique ways, are identified as factors that can develop self-leadership. The purpose of this study was to investigate the effect of everyday creativity and communication ability to self-leadership of nursing students. Method(s): The study conducted 157 nursing students in the first and third grades who agree with study participation. Data were collected using a structured questionnaire from August to October 2020. SPSS/WIN 25.0 program was used to conduct statistical analyses, including descriptive statistics, an independent t-test, a one-way analysis of variance, and stepwise multiple linear regression. Result(s): Self-leadership based on general characteristics showed statistically significant differences in grade, economic level, and way of living. Also everyday creativity and communication skills showed statistically significant differences in gender. Self-leadership of nursing students showed that statistically significant positive correlations in the order of everyday creativity (r=.881, p<.01), communication ability (r=.829, p<.01). Stepwise multiple linear regression demonstrated that everyday creativity explained 59.0% of the variance in self-leadership. Conclusion(s): Through this study, positive correlation was confirmed between self-leadership, everyday creativity, and communication ability of nursing students, and it was found that everyday creativity has the greatest influence on self-leadership. Therefore, it suggests that further research is needed on the development and effectiveness of self-leadership programs that can improve everyday creativity and communication skills of nursing students.
hpRNA-induced gene silencing in Beauveria bassiana JEF-007 for gene characterization
Sihyeon Kim,Se Jin Lee,Mi Rong Lee,Jong Cheol Kim,So Eun Park,Jae Su Kim 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.10
A genus of entomopathogenic Beaveria bassiana has been widely used in pest management, however little studies havebeen given to its virulence-related genes. To identify the roles of virulence genes, AtMT-induced random mutants weregenerated and followed by localization study with TAIL-PCR. Two genes, Complex I intermediated-associated protein30 (CIP30) and Autophagy protein 22 (Atg22), were predicted as virulence-related genes in B.bassiana JEF-007. To validatethe a possible relationship between two genes and fungal virulence, hpRNAi was performed. A hpRNAi plasmid wasconstructed as a model system to knock down of egfp gene in egfp-expressing B. bassiana transformant. A Real-TimePCR showed the knock down of egfp gene expression via hpRNAi. The CIP30 and Atg22 genes in B. bassiana willbe validated by the established RNAi technique. This work can be a strong platform for the functional genetics in B.bassiana.
Sihyeon Kim,Se Jin Lee,Mi Rong Lee,Jong Cheol Kim,So Eun Park,Jae Su Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04
Beauveria bassiana (Bb) is a potential biopesticide against western flower thrips. To understand molecular characteristics of two Bb isolates (ERL836 and JEF-007), whole genome sequencing and RNA-seq were performed. The whole genome of Bb ERL836 was sequenced (3,934,801,443 bp) using Pacbio sequencing and 15 contigs were analyzed. To understand the molecular mechanisms of pathogenicity in two Bb genome (before infection and after infection), next generation sequencing (NGS) was analyzed to compare transcriptomes. A result of differentially expressed gene (DEG) showed that 2,689 contigs were up-regulated and 2,619 contigs were down-regulated. Randomly selected five genes were validated to be highly up-regulated. This work can provide an understanding of the interaction between Bb and westetn flower thrips.
Sihyeon Kim,Jong Cheol Kim,Mi Rong Lee,So Eun Park,Dongwei Li,Sehyeon Baek,Laila Gasmi,Min Sung Jo,Tae Young Shin,Junheon Kim,Jae Su Kim 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04
Insect killing fungus Beauveria bassiana has been widely studied as a biological control agent. However, many studies have been focused on lab or field-based management. Herein this work, comparison of three B. bassiana strains was investigated under a molecular level. The whole genome sequences of ERL836, JEF-007 were analyzed by PacBio (35.5 Mb of ERL836 and 36.5 Mb of JEF-007) and ARSEF2860 referenced from GenBank (33.7 Mb). To compare the three strains, virulence, thermotolerance and chemical resistance were assayed. The transcriptomes of non-infecting B. bassiana and infecting B. bassiana against western flower thrips were analyzed using RNA-seq. This work can provide that genome features, functions, morphology and gene expression could be different under the molecular level, even if in the same species.