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- 저자 : Shrikant V. Joshi (검색결과 2 건)
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Effect of Oroxylum indicum on intestinal motility in rodents
Joshi, Shrikant V.,Gandhi, Tejal R.,Vyas, Bhavin A.,Shah, Payal D.,Patel, Paras K.,Vyas, Heta G. 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.4
Oroxylum indicum is traditional herbal medicine in India, China and Japan used for its anti-diarrhoeal/anti-dysenteric activity, also found to be active against experimentally induced (DNBS induced) inflammatory bowel disease in rats with potential reduction in diarrhoea. It promotes us to evaluate effects of Oroxylum indicum on intestinal motility, both in vitro and in vivo, in rodents. Flavonoids rich fraction of O. indicum was obtained and the effect of extract on contraction of acetylcholine, barium chloride and electrical field stimulation was studied on isolated rabbit ileum. Anti-diarrhoeal activities were investigated using castor oil and magnesium sulphate-induced diarrhoeal models in mice. Effect on intestinal motility was studied using gastrointestinal motility and antienteropooling assay methods. Antimicrobial activity of extract was evaluated using disc diffusion assay method. Extract inhibited the contractions induced by acetylcholine, barium chloride and electrical field stimulation. Verapamil potentiates inhibitory effect of extract. Extract showed significant and dose-dependent antidiarrhoeal effect devoid of altering gastrointestinal motility in normal animals. It also inhibited the microbial growth in disc diffusion assay method. Extract normalized intestinal motility altered by inflammatory stimulus and possesses antidiarrhoeal activity. Alteration of intestinal motility may involve modification in L-type $Ca^{2+}$ channels.
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Suhash R. Dey,Sreekanth Mandati,Bulusu V. Sarada,Shrikant V. Joshi 대한금속·재료학회 2015 ELECTRONIC MATERIALS LETTERS Vol.11 No.4
1. INTRODUCTION Cu(In,Ga)Se2 (CIGS) based solar cells have yielded highest conversion efficiencies (≈21%) among thin-film technologies due to their suitable direct bandgap and large optical absorption coefficient.[1-7] The most efficient CIGS devices have been known to use CdS as the buffer layer to yield a heterojunction that improves absorption in the space charge region and field assisted electron hole separation, while minimizing detrimental interface recombination.[8,9] In pursuit of scalable methods to realize commercialization of these devices, electrodeposition has been proven to be one of the simplest and economical methods, yielding CIGS based cells with high efficiencies ranging from 13 - 16% with CdS being deposited using chemical bath deposition (CBD) technique.[10-14] Conventional direct current electrodeposition of CIGS films employing a three-electrode system often requires multisteps and/or use of complexing agents during deposition, followed by selenization of electrodeposited precursor layer to obtain stoichiometric chalcopyrite CIGS films.[11,13,15] Several reports have also appeared on electrodeposition of CIS/CIGS films without selenization; however, The present study demonstrates the fabrication of a CIGS/CdS heterojunction with enhanced photoelectrochemical performance using low-cost non-vacuum methods. A simplified economical pulse electrodeposition technique, with a two-electrode system in an additive-free electrolyte, has been used for the preparation of chalcopyrite Cu(In,Ga)Se2 (CIGS) thin-films avoiding the selenization process and CdS subsequently chemical bath deposited onto these CIGS films. Photoelectrochemical (PEC) performance of bare CIGS and the CIGS/CdS heterojunction has been investigated in conventional Na2SO4 electrolyte under chopped solar simulated light. The PEC analysis reveals nearly twenty-fold increase in the photoresponse of the CIGS/CdS heterojunction compared to bare CIGS films. The CIGS/CdS junction has also been tested in a PEC cell using a novel sulphide/sulphite electrolyte for the first time and found to yield further enhancement in photocurrent density with exceptional stability. Thus, apart from fabrication of an efficient CIGS/CdS heterojunction economically, the present study proposes use of a novel electrolyte yielding superior performance and showing potential for commercialization of CIGS devices and their use in photoelectrochemical cells.
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