http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Shrestha, H.,Yuan, T.,He, Y.,Moon, P.G.,Shrestha, N.,Ryu, T.,Park, S.Y.,Cho, Y.C.,Lee, C.H.,Baek, M.C.,Cho, S.,Simkhada, S.,Kim, H.,Kim, K. Elsevier Biomedical Press 2016 Biochimica et biophysica acta, Molecular cell rese Vol.1863 No.9
Ubiquitination, a post-translational modification, involves the covalent attachment of ubiquitin to the target protein. The ubiquitin-proteasome pathway and the endosome-lysosome pathway control the degradation of the majority of eukaryotic proteins. Our previous study illustrated that δ-catenin ubiquitination occurs in a glycogen synthase kinase-3 (GSK-3) phosphorylation-dependent manner. However, the molecular mechanism of δ-catenin ubiquitination is still unknown. Here, we show that the lysine residues required for ubiquitination are located mainly in the C-terminal portion of δ-catenin. In addition, we provide evidence that β-TrCP-1 interacts with δ-catenin and functions as an E3 ligase, mediating δ-catenin ubiquitin-proteasome degradation. Furthermore, we prove that both the ubiquitin-proteasome pathway and the lysosome degradation pathway are involved in δ-catenin degradation. Our novel findings on the mechanism of δ-catenin ubiquitination will add a new perspective to δ-catenin degradation and the effects of δ-catenin on E-cadherin involved in epithelial cell-cell adhesion, which is implicated in prostate cancer progression.
Shrestha, N.P.,Edwards, S.A.,English, P.R.,Robertson, J.F. Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.5
The effects of housing and nutrition on the performance of first lactation sows of the Nepalese Pakhribas breed were investigated. A total of 36 sows, from a previous experiment on nutrition during gilt rearing, were allocated according to a factorial design with 2 levels of nutrition, 60 or 80% of the calculated lactation requirement, and two types of housing, traditional or improved. The mean live weight loss of sows during lactation was reduced to a slightly greater extent by improved housing (p<0.05) than by better nutrition (p<0.10). There was also a significantly lower loss of $P_2$ backfat thickness (p<0.05) and mean body condition score (p<0.05) for sows on the higher plane of nutrition. Piglet weight gain in early and mid lactation was influenced by gestation feeding of the gilt (p<0.10) and by housing (p<0.05). Late lactation gain was influenced only by lactation feeding (p<0.05). In consequence, piglet weight at 42 day weaning was increased to a similar extent by improved housing (p<0.05) and better lactation nutrition (p<0.01). Significantly more sows were remated by day 10 after weaning from a higher level of rearing nutrition ($x^2=13.57$, p=0.001), and from improved housing and improved lactation (both $x^2=4.57$, p=0.033). It is concluded that, under Nepalese village conditions, improvements in housing may be a more cost effective way of improving sow performance than expenditure on additional feed resources.
Shrestha, N.P.,Edwards, S.A.,English, P.R.,Robertson, J.F. Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.1
The effects of housing and nutrition on the performance of growing gilts of the Nepalese Pakhribas breed were investigated. A total of 36 pigs were allocated according to a factorial design with 3 levels of nutrition, provided to achieve a target growth rate of 200, 300 or 400 g/day, and two types of housing, traditional or improved. The growth rate and body composition were monitored during the growing period and subsequent pregnancy. There was a significantly higher growth rate (p<0.01), greater $P_2$ backfat thickness (p<0.01), and greater eye muscle depth (p<0.01) at service in pigs given the higher level of nutrition. Similarly, there was a significantly higher growth rate (p<0.05), and greater eye muscle depth (p<0.10) with improved housing but no significant difference in $P_2$ backfat thickness. The conception rate was 90% at first service, with no difference between treatments. Gilts from the high plane of rearing produced a mean litter size of one piglet greater than those on the low plane, but this was not significant with the limited numbers. However, both improved plane of nutrition and reduced climatic penalty by improving housing resulted in increased birthweight of piglets (p<0.05). It is concluded that improvement in housing can give benefits equivalent to at least a 7% improvement in efficiency of feed use under traditional Nepalese circumstances for pig rearing.
Shrestha, N.P.,Edwards, S.A.,English, P.R.,Robertson, J.F. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.5
A prolonged farrowing interval is common on small farms in Nepal and may be attributable to the absence of boar contact at the time of weaning. To examine whether synthetic boar pheromone spray might be of value to aid the stimulation and detection of estrus, 30 village farms, each with a single sow, were recruited into a field study. All sows entered the study on final weaning from their first lactation at 56 days post partum. For 13 treatment sows, a boar pheromone spray (SOA, Intervet, Boxmeer, The Netherlands) was applied each day after weaning whilst 17 other sows did not receive any stimulus (negative control). When estrous was detected by the farmer, sows were taken to the nearest boar for service. There was a significantly shorter weaning to re-mating interval for treatment sows (42.9 V 82.2 day, p<0.05), with a significantly higher proportion of treatment sows rebred by day 60 after weaning (p=0.024, Fishers Test). It is concluded that use of boar pheromones can improve reproductive efficiency of sows kept under Nepalese village conditions.
Shrestha, N.P.,Oli, K.P.,Gatenby, R.M. Asian Australasian Association of Animal Productio 1994 Animal Bioscience Vol.7 No.2
The lactation milk yields of 209 buffaloes and cattle were measured on farms in Taplejung and Dhankuta Districts in East Nepal. This includes local and crossbred buffaloes and cows. The average milk yield (${\pm}\;SD$) of 97 local buffaloes was $833\;{\pm}\;94.6\;kg$ whereas that for 83 local cows was only $455\;{\pm}\;61.5\;kg$. The milk yield of buffaloes decreased with number of calvings, but that for the cows increased. The milk yields of 18 Murrah crossbreds were on average 215 kg higher than the yields of local buffaloes, and the yields of 11 Jersey crossbred cows averaged 247 kg more than the local cows. Lactation length (${\pm}\;SD$) which averaged $326\;{\pm}\;100$ days for the buffaloes and $292\;{\pm}\;98$ days for the cows, was not affected by crossbreeding. The milk yields of the crossbreds were more variable than the local buffaloes and cows. In addition to milk yield the overall productivity of a milking animal depends on calf mortality, age at first calving, calving interval, longevity, food intake, the work performance of male cattle and the meat production of male buffaloes. Among these parameters, the work performance of Jersey crossbred and local male cattle was studied later. However, other factors could not be measured.
EGG SHELL PARAMETERS IN PHILIPPINE NATIVE CHICKENS AND THEIR UPGRADES
Rasali, D.P.,Shrestha, N.P.,Mudgal, V.D.,Serrano, J.V. Jr.,dp Palad, M.,Lambio, A.L. Asian Australasian Association of Animal Productio 1993 Animal Bioscience Vol.6 No.1
Least square means for egg weight (EW), average shell thickness (ST), shape index (SI), shell surface area (SA) and shell breaking strength (BS) were determined in the Philippine native (PN) and F2 upgrades with New Hampshire (NH-N) and White Leghorn (WL-N) blood, respectively. Eggs of PN were smaller in size but had higher SI while their egg shells were thinner and weaker than those of the two upgrades. Highest EW, SA and BS means were observed in WL-N. Significant (p<0.01) positive correlations of EW and SI with SA and BS were noted.