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- 저자 : Shortridge, Randall D. (검색결과 3 건)
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A Drosophila Phospholipase C Gene That Is Expressed in the Central Nervous System
Shortridge, Randall D.,Yoon, Jaeseung,Lending, Craig R.,Bloomquist, Brian T.,Perdew, Marcia H.,Pak, William L. 경희대학교 유전공학연구소 1991 遺傳工學論文集 Vol.3 No.-
A Drosophila phospholipase C (PLC) gene, designated as plc-21, was isolated by screening a genomic DNA library using a cDNA for a previously isolated Drosophila PLC gene, norpA, as probe under reduced stringency hybridization conditions. The gene maps to 21C on the left arm of the second chromosome. Two proteins of 1305 and 1312 amino acids, respectively, were deduced from two classes of cDNA which were isolated. The two putative plc-21 proteins are similar in sequence and overall structure to the β-class of PLCs found in mammals and differ from each other only by 7 amino acid residues that are present near the C terminus of one of the proteins but not the other. Hybridization of plc-21 cDNA probes to blots of poly(A)^(+) RNA revealed that the gene encodes a 7.0-kilobase transcript that could be detected in the head but not in the body of adult flies and a 5.6-kilobase transcript that could be detected throughout development and in both heads and bodies of adults. I n situ hybridization of cDNA sequences to tissue sections showed that the gene is expressed in the neuronal cell bodies of the optic lobe, central brain, and thoracic ganglia of adults and the brain of larvae. This tissue distribution of plc-21 transcripts is identical to the distribution of transcripts from a Drosophila Go a-subunit gene that we reported previously.
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Lee, Eun-Hyun,van der Bijl, Jaap,Shortridge-Baggett, Lillie M.,Han, Seung Jin,Moon, Seung Hei Hindawi Publishing Corporation 2015 International Journal of endocrinology Vol.2015 No.-
<P><I>Objectives</I>. The aims of this study were to perform a cultural translation of the DMSES and evaluate the psychometric properties of the translated scale in a Korean population with type 2 diabetics. <I>Methods</I>. This study was conducted in patients with diabetes recruited from university hospitals. The first stage of this study involved translating the DMSES into Korean using a forward- and backward-translation technique. The content validity was assessed by an expert group. In the second stage, the psychometric properties of the Korean version of the DMSES (K-DMSES) were evaluated. <I>Results</I>. The content validity of the K-DMSES was satisfactory. Sixteen-items clustered into four-subscales were extracted by exploratory factor analysis, and supported by confirmatory factor analysis. The construct validity of the K-DMSES with the Summary of Diabetes Self-Care Activities scale was satisfactory (<I>r</I> = 0.50, <I>P</I><0.001). The Cronbach's alpha and intraclass correlation coefficient were 0.92 and 0.85 (<I>P</I><0.001; 95% CI = 0.75–0.91), respectively, which indicate excellent internal consistency reliability and test-retest reliability. <I>Conclusions</I>. The K-DMSES is a brief instrument that has demonstrated good psychometric properties. It is therefore feasible to use in practice, and is ready for use in clinical research involving Korean patients with type 2 diabetes.</P>
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Rapid Clinical Bacteriology and Its Future Impact
Alex van Belkum,Géraldine Durand,Michel Peyret,Sonia Chatellier,Gilles Zambardi,Jacques Schrenzel,Dee Shortridge,Anette Engelhardt,William Michael Dunne Jr 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.1
Clinical microbiology has always been a slowly evolving and conservative science. The sub-field of bacteriology has been and still is dominated for over a century by culturebased technologies. The integration of serological and molecular methodologies during the seventies and eighties of the previous century took place relatively slowly and in a cumbersome fashion. When nucleic acid amplification technologies became available in the early nineties, the predicted “revolution” was again slow but in the end a real paradigm shift did take place. Several of the culture-based technologies were successfully replaced by tests aimed at nucleic acid detection. More recently a second revolution occurred. Mass spectrometry was introduced and broadly accepted as a new diagnostic gold standard for microbial species identification. Apparently, the diagnostic landscape is changing, albeit slowly, and the combination of newly identified infectious etiologies and the availability of innovative technologies has now opened new avenues for modernizing clinical microbiology. However, the improvement of microbial antibiotic susceptibility testing is still lagging behind. In this review we aim to sketch the most recent developments in laboratory-based clinical bacteriology and to provide an overview of emerging novel diagnostic approaches.
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