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        Are Clinical, Laboratory, and Imaging Markers Suitable Predictors of Vesicoureteral Reflux in Children With Their First Febrile Urinary Tract Infection?

        Abolfazl Mahyar,Parviz Ayazi,Shiva Mavadati,Sonia Oveisi,Morteza Habibi,Shiva Esmaeily 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.8

        Purpose: This study was conducted to determine the predictive value of clinical, laboratory,and imaging variables for the diagnosis of vesicoureteral reflux in children withtheir first febrile urinary tract infection. Materials and Methods: One hundred fifty-three children with their first febrile urinarytract infection were divided into two groups according to the results of voiding cystourethrography:60 children with vesicoureteral reflux and 93 children without. Thesensitivity, specificity, positive and negative predictive value, likelihood ratio (positiveand negative), and accuracy of the clinical, laboratory, and imaging variables for thediagnosis of vesicoureteral reflux were determined. Results: Of the 153 children with febrile urinary tract infection, 60 patients (39.2%)had vesicoureteral reflux. There were significant differences between the two groupsregarding fever>38oC, suprapubic pain, C-reactive protein quantitative level, numberof red blood cells in the urine, and results of renal ultrasound and dimercaptosuccinicacid renal scanning (p<0.05). There were significant positive correlations between fever>38.2oC and dimercaptosuccinic acid renal scanning and vesicoureteral reflux. Also, there were significant positive correlations between the erythrocyte sedimentationrate, positive urinary nitrite test, hyaline cast, and renal ultrasound andhigh-grade vesicoureteral reflux. Conclusions: This study revealed fever>38.2oC and dimercaptosuccinic acid renalscanning as the best predictive markers for vesicoureteral reflux in children with theirfirst febrile urinary tract infection. In addition, erythrocyte sedimentation rate, positiveurinary nitrite test, hyaline cast, and renal ultrasound are the best predictivemarkers for high-grade vesicoureteral reflux.

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