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- 저자 : Shirafkan, Azadeh (검색결과 4 건)
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Azadeh Shirafkan,Seyed Mostafa Nowee,Hossein Kamali 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.9
This paper concerns optimization and experimental validation of coprecipitation process parameters forpreparing particles of Pyrazinamide and Polyvinylpyrrolidone using gas anti-solvent supercritical method. Mixtures oforganic solvents (acetone and ethanol) were selected with various combinations of the drug and the polymer. The centralcomposite design (CCD) was adopted to explore the effect of temperature, pressure, antisolvent addition rate, polymerfraction, and ethanol fraction on particle size distribution (PSD) and solubility. The strong likelihood models weredeveloped for all the responses using Design-Expert software. Polymer fraction was the most important (p<0.0001)factor influencing PSD, while pressure and interaction between temperature and polymer fraction significantly affectedsolubility. The optimal condition was specified at temperature of 50 oC, pressure of 120 bar, antisolvent rate of 16 bar/min, polymer fraction of 30%, and ethanol fraction of 50%. The model was then validated experimentally under theoptimal condition and compared with pure PZA and particles obtained from the physical mixture. According to DLS,XRD, FTIR, and FESEM analyses, the crystallinity of PZA-PVP particles was reduced in optimum conditions, leadingto higher solubility. Also, the results suggest that it is feasible to produce coprecipitated particles with narrower size distributionby optimized GAS process.
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On the $C$-projective vector fields on Randers spaces
Mehdi Rafie-Rad,Azadeh Shirafkan 대한수학회 2020 대한수학회지 Vol.57 No.4
A characterization of the $C$-projective vector fields on a Randers space is presented in terms of ${\bf\Xi}$-curvature. It is proved that the ${\bf\Xi}$-curvature is invariant for $C$-projective vector fields. The dimension of the algebra of the $C$-projective vector fields on an $n$-dimensional Randers space is at most $n(n+2)$. The generalized Funk metrics on the $n$-dimensional Euclidean unit ball $\mathbb{B}^n(1)$ are shown to be explicit examples of the Randers metrics with a $C$-projective algebra of maximum dimension $n(n+2)$. Then, it is also proved that an $n$-dimensional Randers space has a $C$-projective algebra of maximum dimension $n(n+2)$ if and only if it is locally Minkowskian or (up to re-scaling) locally isometric to the generalized Funk metric. A new projective invariant is also introduced.
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ON THE C-PROJECTIVE VECTOR FIELDS ON RANDERS SPACES
Rafie-Rad, Mehdi,Shirafkan, Azadeh Korean Mathematical Society 2020 대한수학회지 Vol.57 No.4
A characterization of the C-projective vector fields on a Randers space is presented in terms of 𝚵-curvature. It is proved that the 𝚵-curvature is invariant for C-projective vector fields. The dimension of the algebra of the C-projective vector fields on an n-dimensional Randers space is at most n(n + 2). The generalized Funk metrics on the n-dimensional Euclidean unit ball 𝔹<sup>n</sup>(1) are shown to be explicit examples of the Randers metrics with a C-projective algebra of maximum dimension n(n+2). Then, it is also proved that an n-dimensional Randers space has a C-projective algebra of maximum dimension n(n + 2) if and only if it is locally Minkowskian or (up to re-scaling) locally isometric to the generalized Funk metric. A new projective invariant is also introduced.
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Ghasemali, Samaneh,Nejati-Koshki, Kazem,Akbarzadeh, Abolfazl,Tafsiri, Elham,Zarghami, Nosratollah,Rahmati-Yamchi, Mohamad,Alizadeh, Effat,Barkhordari, Amin,Tozihi, Majid,Kordi, Shirafkan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Nowadays, the encapsulation of cytotoxic chemotherapeutic agents is attracting interest as a method for drug delivery. We hypothesized that the efficiency of helenalin might be maximized by encapsulation in ${\beta}$-cyclodextrin nanoparticles. Helenalin, with a hydrophobic structure obtained from flowers of Arnica chamissonis and Arnica Montana, has anti-cancer and anti-inflammatory activity but low water solubility and bioavailability. ${\beta}$-Cyclodextrin (${\beta}$-CD) is a cyclic oligosaccharide comprising seven D-glucopyranoside units, linked through 1,4-glycosidic bonds. Materials and Methods: To test our hypothesis, we prepared ${\beta}$-cyclodextrin-helenalin complexes to determine their inhibitory effects on telomerase gene expression by real-time polymerase chain reaction (q-PCR) and cytotoxic effects by colorimetric cell viability (MTT) assay. Results: MTT assay showed that not only ${\beta}$-cyclodextrin has no cytotoxic effect on its own but also it demonstrated that ${\beta}$-cyclodextrin-helenalin complexes inhibited the growth of the T47D breast cancer cell line in a time and dose-dependent manner. Our q-PCR results showed that the expression of telomerase gene was effectively reduced as the concentration of ${\beta}$-cyclodextrin-helenalin complexes increased. Conclusions: ${\beta}$-Cyclodextrin-helenalin complexes exerted cytotoxic effects on T47D cells through down-regulation of telomerase expression and by enhancing Helenalin uptake by cells. Therefore, ${\beta}$-cyclodextrin could be superior carrier for this kind of hydrophobic agent.
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