http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effectiveness of transabdominal ultrasonography in predicting clinical relapse of Crohn’s disease
Shinya Fukushima,Takehiko Katsurada,Mutsumi Nishida,Satomi Omotehara,Kensuke Sakurai,Kana Yamanashi,Reizo Onishi,Naoya Sakamoto 대한장연구학회 2024 Intestinal Research Vol.22 No.1
Background/Aims: Transabdominal ultrasonography (US) helps evaluate Crohn’s disease (CD) activity. We investigated whether the US could predict subsequent adverse outcomes for patients with CD in clinical remission.Methods: This single-center retrospective study included patients with CD in clinical remission who underwent US between April 2011 and April 2021, focusing on the predictability of subsequent adverse outcomes within 5 years. We used the US-CD, which was calculated using multiple US findings. Predictive variables were assessed using Cox proportional hazards regression analysis, and the predictive value was evaluated using receiver operating characteristic curves.Results: Seventy-three patients were included. During a median follow-up of 1,441 days (range, 41–1,825 days), 16.4% (12/73) experienced clinical relapse, 9.6% (7/73) required endoscopic balloon dilation (EBD), 58.9% (43/73) required enhanced treatment, and 20.5% (15/73) underwent surgery. In the multivariate analysis, US-CD was significantly associated with clinical relapse (<i>P</i>= 0.038) and the need for enhanced treatment (<i>P</i>= 0.005). The area under the receiver operating characteristic curve for predicting clinical relapse and the need for EBD was 0.77 and 0.81, respectively, with US-CD (cutoff value = 11), and that for requiring enhanced treatment was 0.74 with US-CD (cutoff value = 6). Patients with US-CD ≥ 11 demonstrated a significantly higher occurrence of clinical relapse (<i>P</i>= 0.001) and EBD (<i>P</i>= 0.002) within 5 years. Patients with US-CD ≥ 6 experienced a significantly higher likelihood of requiring enhanced treatment (<i>P</i>< 0.001) within 5 years.Conclusions: High US-CD is associated with subsequent adverse outcomes in patients with CD.
Hattori, Shigeki,Kano, Shinya,Azuma, Yasuo,Tanaka, Daisuke,Sakamoto, Masanori,Teranishi, Toshiharu,Majima, Yutaka IOP Pub 2012 Nanotechnology Vol.23 No.18
<P>Coulomb blockade behaviors in individual Au nanoparticles of 2 nm core diameter in double-barrier structures have been studied by means of noncontact atomic force spectroscopy (NC-AFS) at room temperature. The Au nanoparticles with a 1-decanethiol ligand were chemisorbed by 1,10-decanedithiol molecules of a mixed 1-octanethiol/1,10-decanedithiol self-assembled monolayer coated on a Au(111) surface; these particles were observed through NC-AFS. NC-AFS measurements of the cantilever frequency shift–sample voltage (&Dgr;f–V<SUB>S</SUB>) curves were sequentially conducted on three Au nanoparticles under the same experimental conditions; the &Dgr;f–V<SUB>S</SUB> curves were found to deviate from the parabolic (&Dgr;f<SUB>N</SUB>) curve in the cases where no extra charge existed on the Au core. The experimental &Dgr;f<SUB>CB</SUB>(=&Dgr;f − &Dgr;f<SUB>N</SUB>) and &Dgr;f<SUB>CB</SUB>/V curves agree well with the theoretical curves obtained using a golden-rule calculation and the same parabolic parameters. All the results, through NC-AFS, suggest Coulomb blockade behaviors in the Au nanoparticles at room temperature.</P>
Logic Operations of Chemically Assembled Single-Electron Transistor
Maeda, Kosuke,Okabayashi, Norio,Kano, Shinya,Takeshita, Shuhei,Tanaka, Daisuke,Sakamoto, Masanori,Teranishi, Toshiharu,Majima, Yutaka American Chemical Society 2012 ACS NANO Vol.6 No.3
<P>Double-gate single-electron transistors (SETs) were fabricated by chemical assembling using electroless gold-plated nanogap electrodes and chemisorbed chemically synthesized gold nanoparticles. The fabricated SET showed periodic and stable Coulomb oscillations under application of voltages of both gates. The sole SET also exhibited all two-input logic operations?XOR, XNOR, NAND, OR, NOR, and AND?with an on/off ratio of 10<SUP>2</SUP>. This demonstrates the potential of chemical assembling to give highly stable SETs exhibiting all logic operations.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2012/ancac3.2012.6.issue-3/nn3003086/production/images/medium/nn-2012-003086_0006.gif'></P>
Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis
Kensuke Sakurai,Takehiko Katsurada,Mutsumi Nishida,Satomi Omotehara,Shinya Fukushima,Shinsuke Otagiri,Kazunori Nagashima,Reizo Onishi,Ryo Takagi,Yoshito Komatsu,Sakamoto Naoya 대한장연구학회 2023 Intestinal Research Vol.21 No.1
Background/Aims: The usefulness of ultrasonography (US) in diseases of the gastrointestinal tract has been reported recently. This prospective study aimed to determine the features of US findings in immune-mediated colitis (IMC), an adverse event induced by immune checkpoint inhibitor, and examine the correlation between US findings, colonoscopy (CS) findings, and severity of colitis. Methods: We studied patients examined using CS and US upon suspicion of IMC in Hokkaido University Hospital between April 2018 and February 2021. Endoscopic findings of IMC were assessed using the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). The severity of US findings in IMC was evaluated using US grade, which is the ultrasonographic grading scale in ulcerative colitis. Bowel wall thickness and the intensity of the color Doppler signal were also analyzed. Severity of colitis was evaluated using Common Terminology Criteria for Adverse Events (CTCAE) grade version 5. Results: Fourteen patients with IMC were enrolled. The US findings were bowel wall thickening, loss of stratification, ulceration and increased blood flow signal. The US grade was moderately correlated with the UCEIS (r=0.687, P=0.009) and CTCAE grade (r=0.628, P=0.035). Bowel wall thickness and UCEIS (r=0.628, P=0.020), as well as color Doppler signal grade and CTCAE grade (r=0.724, P=0.008), were significantly correlated. Conclusions: US findings in IMC were mainly similar to those of ulcerative colitis, but there were some findings that were characteristic only of IMC. Significant correlation was found between US findings, CS findings, and severity of colitis. Hence, US could be useful for the evaluation of IMC.
Yuichi Tomiki,Jun Aoki,Shunsuke Motegi,Rina Takahashi,Toshiaki Hagiwara,Yu Okazawa,Kosuke Mizukoshi,Masaya Kawai,Shinya Munakata,Shun Ishiyama,Kiichi Sugimoto,Kazuhiro Sakamoto 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.6
Background/Aims: Sclerotherapy with aluminum potassium sulfate and tannic acid (ALTA) has a potent effect on internalhemorrhoids. In this retrospective study, we compared the effects of endoscopic ALTA therapy and standard ALTA therapy. Methods: We investigated patients who underwent treatment for internal hemorrhoids at our institution between 2014 and 2016. Theywere divided into a standard ALTA group (n=33, treated using proctoscopy) and an endoscopic ALTA group (n=48). We compared theclinical findings between the 2 groups. Results: There were no intergroup differences in background factors. The mean ALTA dose was 21.9±7.2 mL and 17.8±3.4 mL inthe standard and endoscopic ALTA groups, respectively (p<0.01). Adverse events occurred in 4 patients (12.1%) from the standardALTA group and 6 patients (12.5%) from the endoscopic ALTA group. In both groups, the patients reported good satisfaction withthe therapeutic effect at 1 month after the procedure. Hemorrhoids recurred in 2 patients (6.3%) from the standard ALTA group and 4patients (8.3%) from the endoscopic ALTA group. Conclusions: Endoscopic ALTA sclerotherapy is equivalent to standard ALTA therapy in terms of efficacy, adverse events, andrecurrence. Therefore, it is a useful non-surgical option for patients with internal hemorrhoids who prefer a less invasive treatment.
Remote Cardiac Rehabilitation With Wearable Devices
Atsuko Nakayama,Noriko Ishii,Mami Mantani,Kazumi Samukawa,Rieko Tsuneta,Megumi Marukawa,Kayoko Ohno,Azusa Yoshida,Emiko Hasegawa,Junko Sakamoto,Kentaro Hori,Shinya Takahashi,Kaoruko Komuro,Takashi Hir 대한심장학회 2023 Korean Circulation Journal Vol.53 No.11
Although cardiac rehabilitation (CR) has been shown to improve exercise tolerance and prognosis in patients with cardiovascular diseases, there remains low participation in outpatient CR. This may be attributed to the patients’ busy schedules and difficulty in visiting the hospital due to distance, cost, avoidance of exercise, and severity of coronary disease. To overcome these challenges, many countries are exploring the possibility of remote CR. Specifically, there is increasing attention on the development of remote CR devices, which allow transmission of vital information to the hospital via a remote CR application linked to a wearable device for telemonitoring by dedicated hospital staff. In addition, remote CR programs can support return to work after hospitalization. Previous studies have demonstrated the effects of remote CR on exercise tolerance. However, the preventive effects of remote CR on cardiac events and mortality remain controversial. Thus, safe and effective remote CR requires exercise risk stratification for each patient, telenursing by skilled staff, and multidisciplinary interventions. Therefore, quality assurance of telenursing and multi-disciplinary interventions will be essential for remote CR. Remote CR may become an important part of cardiac management in the future. However, issues such as cost-effectiveness and insurance coverage still persist.