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Park, Yeonkyung,Lee, Chang Yeol,Kang, Shinyoung,Kim, Hansol,Park, Ki Soo,Park, Hyun Gyu IOP 2018 Nanotechnology Vol.29 No.8
<P>In this work, we developed a novel, label-free, and enzyme-free strategy for the colorimetric detection of microRNA (miRNA), which relies on a target-catalyzed toehold-mediated strand displacement (TMSD) reaction. The system employs a detection probe that specifically binds to the target miRNA and sequentially releases a catalyst strand (CS) intended to trigger the subsequent TMSD reaction. Thus, the presence of target miRNA releases the CS that mediates the formation of an active G-quadruplex DNAzyme which is initially caged and inactivated by a blocker strand. In addition, a fuel strand that is supplemented for the recycling of the CS promotes another TMSD reaction, consequently generating a large number of active G-quadruplex DNAzymes. As a result, a distinct colorimetric signal is produced by the ABTS oxidation promoted by the peroxidase mimicking activity of the released G-quadruplex DNAzymes. Based on this novel strategy, we successfully detected miR-141, a promising biomarker for human prostate cancer, with high selectivity. The diagnostic capability of this system was also demonstrated by reliably determining target miR-141 in human serum, showing its great potential towards real clinical applications. Importantly, the proposed approach is composed of separate target recognition and signal transduction modules. Thus, it could be extended to analyze different target miRNAs by simply redesigning the detection probe while keeping the same signal transduction module as a universal signal amplification unit, which was successfully demonstrated by analyzing another target miRNA, let-7d.</P>
Alternative Patterning Process for Realization of Large-Area, Full-Color, Active Quantum Dot Display
Park, Joon-Suh,Kyhm, Jihoon,Kim, Hong Hee,Jeong, Shinyoung,Kang, JoonHyun,Lee, Song-ee,Lee, Kyu-Tae,Park, Kisun,Barange, Nilesh,Han, JiYeong,Song, Jin Dong,Choi, Won Kook,Han, Il Ki American Chemical Society 2016 Nano letters Vol.16 No.11
<P>Although various colloidal quantum dot (QD) coating and patterning techniques have been developed to meet the demands in optoelectronic applications over the past years, each of the previously demonstrated methods has one or more limitations and trade-offs in forming multicolor, high-resolution, or large-area patterns of QDs. In this study, we present an alternative QD patterning technique using conventional photolithography combined with charge-assisted layer-by-layer (LbL) assembly to solve the trade-offs of the traditional patterning processes. From our demonstrations, we show repeatable QD patterning process that allows multicolor QD patterns in both large-area and microscale. Also, we show that the QD patterns are robust against additional photolithography processes and that the thickness of the QD patterns can be controlled at each position. To validate that this process can be applied to actual device applications as an active material, we have fabricated inverted, differently colored, active QD light-emitting device (QD-LED) on a pixelated substrate, which achieved maximum electroluminescence intensity of 23 770 cd/m(2), and discussed the results. From our findings, we believe that our process provides a solution to achieving both high-resolution and large-scale QD pattern applicable to not only display, but also to practical photonic device research and development.</P>
( Shinyoung Song ),( Jaewoo Lim ),( Seha Park ),( Seulki Lee ),( Hee Joo Kim ),( Jinok Baek ),( Hyangjoon Park ),( Joo Young Roh ),( Songmi Ahn ),( Kihoon Sung ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Topical applications of a silicone gel have been shown to be effective in promoting accelerated epithelialization, reducing the inflammatory response. Objectives: This study was performed to compare the effectiveness of a topical film-forming silicone gel and a moisturizing cream in reducing radiation dermatitis in patients receiving radiotherapy for breast cancer. Methods: This was a single-centre, unblinded, randomized controlled parallel study that included patients with breast cancer treated with adjuvant breast radiotherapy protocol of 50Gy. A total of 56 patients with breast cancer were randomized to use topical silicone gel or moisturizing cream (1:1). The severity of radiation dermatitis was graded using physiological skin parameters, including the erythema index, melanin index, and transepidermal water loss (TEWL), clinician-assessed visual rating scales and patient-reported symptoms. Results: Two-way repeated-measures ANOVA revealed different patterns of changes in the erythema index (F=3.609, p=0.008) and melanin index (F=3.475, p=0.015). The post hoc analysis demonstrated a significantly lower erythema index and melanin index in the patients allocated to the silicone gel group. There were no significant differences between two groups in the TEWL measurements. Conclusion: This study demonstrated the superiority of a topical film-forming silicone gel compared to moisturizer in reducing severity of radiation dermatitis during breast radiotherapy.
Park, Shinyoung,Yasin, Muhammad,Jeong, Jiyeong,Cha, Minseok,Kang, Hyunsoo,Jang, Nulee,Choi, In-Geol,Chang, In Seop Elsevier Applied Science 2017 Bioresource Technology Vol.245 No.1
<P><B>Abstract</B></P> <P>The acetate-assisted cultivation of <I>Eubacterium limosum</I> KIST612 was found to provide a way for enhancing cell mass, the carbon monoxide (CO) consumption rate, and butyrate production using CO as an electron and energy source. Cell growth (146%), <I>μ</I> <SUB>max</SUB> (121%), and CO consumption rates (151%) increased significantly upon the addition of 30mM acetate to microbial cultures. The main product of CO fermentation by <I>E. limosum</I> KIST612 shifted from acetate to butyrate in the presence of acetate, and 5.72mM butyrate was produced at the end of the reaction. The resting cell experimental conditions indicated acetate uptake and an increase in the butyrate concentration. Three routes to acetate assimilation and energy conservation were suggested based on given experimental results and previously genome sequencing data. Acetate assimilation <I>via</I> propionate CoA-transferase (PCT) was expected to produce 1.5mol ATP/mol butyrate, and was thus anticipated to be the most preferred route.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Significant improvements were achieved in acetate-assisted cultivation. </LI> <LI> The main product was shifted from acetate to butyrate. </LI> <LI> Three possible routes to acetate assimilation and energy conservation were suggested. </LI> <LI> An efficient way for more reduced biochemical products can be suggested. </LI> </UL> </P>
Park, Hyeong Cheol,Lee, Shinyoung,Park, Bokyung,Choi, Wonkyun,Kim, Chanmin,Lee, Sanghun,Chung, Woo Sik,Lee, Sang Yeol,Sabir, Jamal,Bressan, Ray A.,Bohnert, Hans J.,Mengiste, Tesfaye,Yun, Dae-Jin Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.1
In the interaction between plants and pathogens, carbon (C) resources provide energy and C skeletons to maintain, among many functions, the plant immune system. However, variations in C availability on pathogen associated molecular pattern (PAMP) triggered immunity (PTI) have not been systematically examined. Here, three types of starch mutants with enhanced susceptibility to Pseudomonas syringae pv. tomato DC3000 hrcC were examined for PTI. In a dark period-dependent manner, the mutants showed compromised induction of a PTI marker, and callose accumulation in response to the bacterial PAMP flagellin, flg22. In combination with weakened PTI responses in wild type by inhibition of the TCA cycle, the experiments determined the necessity of C-derived energy in establishing PTI. Global gene expression analyses identified flg22 responsive genes displaying C supply-dependent patterns. Nutrient recycling-related genes were regulated similarly by C-limitation and flg22, indicating re-arrangements of expression programs to redirect resources that establish or strengthen PTI. Ethylene and NAC transcription factors appear to play roles in these processes. Under C-limitation, PTI appears compromised based on suppression of genes required for continued biosynthetic capacity and defenses through flg22. Our results provide a foundation for the intuitive perception of the interplay between plant nutrition status and pathogen defense.