비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

수열합성법에 의한 제조된 MCM-41에 담지된 4급암모늄염 촉매를 이용한 페녹시메틸에틸렌 카보네이트의 합성

신동환,유병수,이화수,박대원 한국공업화학회 2003 응용화학 Vol.7 No.1

In the present study, the synthesis of phenoxy methyl ethylene carbonate (PMEC) from carbon dioxide and phenyl glycidyl ether(PGE) was investingated using mesoporous chloropropyl-methyl-MCM-41-supported quaternary ammonium salt catalysts. The influence of the amounl of modifier and quaternary ammonium salt structure on the conversion of PGE was discussed. The MCM-41-immobilized quaternary ammonium salts showed good catalytic activity even at the atmospheric pressure of carbon dioxide, and it could be reused with easy seperation.

노인종합복지관의 이용특성에 따른 이용권 형성에 관한 건축 계획적 연구

신대진,정준수,박용환 대한건축학회 2004 대한건축학회논문집 Vol.20 No.8

The purpose of this study is to analyze the choice of the General Welfare Facilities for the Aged at the view of the distribution of the users and to help to plan the welfare facilities. The number of users' residence is analyzed as compared with factors of transportations and living conditions to find out the characteristics of facility and the distance of using. The 2903 registers in one year are reserved for analyzed and 233 persons also are surveyed in three facilities. The results of this study are as follows; The distribution of using is following to political district and biased against to others. The average catchment area of the facilities is 800m on feet and has diversity according to the transportations and living condition of users.

진화전략과 쌍 선형 회귀성 신경망을 이용한 새로운 태풍 예측 시스템의 개발

信大振,姜渙一 명지대학교 산업기술연구소 2006 産業技術硏究所論文集 Vol.25 No.-

In this paper, we predict the typhoon's track and center pressure after 12 hours using the evolution strategy and the bilinear recurrent neural network(ES_BLRNN). We plot the predicted track of the typhoon along with the predicted center pressure in the 3-dimensional space and we compare the predicted positions and pressures of a given typhoon with its real position and pressure, The dying position of the typhoon is predicted under the conditions that we discover the regularity of the variation of the center pressure of the typhoon. Comparing the predicted track and the real track of a given typhoons, it is shown that the prediction system using the evolution strategy and bilinear recurrent neural network is superior to the existing prediction system such as the numerical approach, the neural network approach and the cliper equation.

항생제 다제내성균 Staphylococcus aureus SA2로부터 분리한 테트라사이클린 내성 플라스미드 pKH6의 염기서열

이대운,윤성준,김우구,신철교,임성환,이백락,문경호 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.4

한국에서 임산균주로부터 분리한 테트라사이클린(Tc) 내성 플라스미드 pKH6의 전체 염기서열을 결정하여 가장 대표적인 Tc 내성 플라스미드인 pT181과 비교하였다. pKH6의 전체 길이는 4439bp로 pT181과 동일하게 나타났으며 염기서열은 7개의 염기에서 차이를 보였다. 전부 다 염기쌍이 치환된 형태로 나타났으며 그 중 3개는 coding 부위에서 일어났다. coding 부위에서 일어난 경우에도 1개는 동일한 아미노산을 coding 하였기 때문에 pT181과 차이가 없었으며 RepC와 Pre 단백질에 있어 각각 1개의 아미노산에서 차이를 나타내었다. The complete nucleotide sequence of pKH6, a tetracycline-resistance (Tc^r) plasmid isolated from multi-drug resistant Staphlococcus aureus SA2, has been determined and compared with that of the staphylococcal Tc^r plasmid pT181. The nucleotide sequences of the two plasmids are in agreement except for 7 nucleotides. All differences are caused by base pair substitutions. Among 6 substitutions, 3 occurred in coding regions. However, only tow base substitutions in coding regions resulted in changes of amino acid sequences in two different ORFs of repC and Pre proteins.

윤곽검출용 CMOS 시각칩의 수평억제기능에 대한 해석

김정환,박대식,박종호,김경문,공재성,신장규,이민호 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

Feed Back 제어를 이용한 감광액 공급용 정량제어 펌프 시스템 개발

김신호,정선환,최성대 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

This study was carried out to develope a flow control system using to supply PR(photo-resist) in the semi-conductor manufacturing process. The features of this system are to be able to measure the high viscosity and micro-flow. To meet above study object some ideas was induced to design a new concept valve with new material, multi-cross wheel, and new sealing method etc.. As the evaluations on the developed micro-flowmeter it was enough satisfied to use at the IT industries such as photo-resist process.

Oxantel/Pyrantel 合劑 및 Mebendazole에 依한 腸內線蟲類 驅蟲效果에 對한 比較實驗

金鍾煥,辛大煥,林定圭 충남대학교 의과대학 지역사회의학연구소 1978 충남의대잡지 Vol.5 No.1

A total of 63 subjects with multiple intestinal nematode infection: T. trichiura, A. lumbricoides, E. vermicularis and T. orientalis were treated with Oxantel/Pyrantel suspension and Mebendazole. The administration of Oxantel/Pyrantel suspension was 15mg/kg body weight in a single dose and Mebendazole was 600mg, divided by 100mg, twice daily for three consecutive days regardless of the body weight or ages. The results of present trials are summarized as follows: 1. The egg negative conversion rates for Oxantel/Pyrantel suspension were 100% in 20 cases of Ascariasis and in 3 cases of T. orientalis infection, and 92.3% in 26 cases of Enterobiasis. The egg reduction rate of T. trichiura was 84.8%. 2. The Mebendazole treated group showed the egg negative conversion rates of 100% in 27 cases of Ascariasis and one case of Trichostrongyliasis, 88.5% in 26 cases of Enterobiasis and 19.4% is 32 cases of Trichuriasis. The egg reduction rate of T. trichiura was 89.4%. 3. With the Oxantel/Pyrantel treated group, adult worms were found T. trichiura 1449 (average 45.3), A. lumbricoides 81 (av. 4.1) and E. vermicularis 249 (av. 9.6) worms. In Mebendazole treated group demonstrated the number of adult worms: 406(av. 13.1) of T. trichiura, 79 (av. 2.9) of A. lumbricoides and 134 (av. 5.2) of E. vermicularis, respectively. 4. Side effects of both Oxantel/Pyrantel and Mebendazole were few and mild.

구강내 결손부에 적용된 연조직 재건술식들에 대한 임상적 고찰

김욱규,이승환,황대석,김용덕,신상훈,김종렬,정인교 부산대학교 병원 암연구소 2007 부산대병원학술지 Vol.- No.21

To evaluate criteria, indications, and prognosis of the various reconstructive methods on the patients with intraoral soft tissue defect who had been treated at Dept. of Oral and Maxillofacial Surgery, Pusan National University Hospital from 2003 to 2005, we have reviewed the clinical data of the patients and analysed. The results were as follows: 1. Tongue flaps have been mainly applied on anterior portion of palate and maxilla. The survival rate was high percent, but the cooperation of patient was inevitable for the success. 2. Palatal mucosa rotational flaps were available on relative large defect on palate, oroantral fistula site. The side effect was a scaring band from secondary healing on denuded donor palate site. Sometimes the band came to be a hinderance to swallowing, phonation. 3. The application of free skin graft on entire maxilla site , palate was possible. The skin from thigh, abdomen could be applicable on fixed or movable tissues. The advantages of abdominal skin were easy harvest and direct donor site closure. 4. Forearm free flap was a workhorse flap for everywhere in intraoral defects. We had used the flap on cheek, floor of mouth, tongue without any significant complications. But the application of the flap was required for long operation time, which was disadvantageous to the old, weak patients. 5. Cervical platysmal flap could be easily applicable for buccal cheek, floor of mouth after excision of the cancer lesion. the design of the flap could be made simultaneously on neck dissection, but the danger of cancer remnants on the flap always might be remained. 6. Buccal fat pad pedicled flap must have been a primary flap for repair of oroantral fistula especially on posterior maxilla. The flap survival will be expected if the considerations for above reconstructivε methods on site, size, condition of defects primarily could be made.

톡소포자충 검출에 있어서 DNA 분리방법 및 반응 조건에 따른 중합효소 연쇄반응의 민감도 비교

이두용,이영하,강문수,나영언,신대환 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

To optimize the PCR for the diagnosis of toxoplasmosis, different DNA extraction method, PCR condition to conform the target DNA and Southern blot hybridization were carried out. The results were as follows. 1. On DNA extraction, G NOME DNA isolation kit method from the tachyzoites of Toxoplasma RH strain and split second DNA isolation kit method from the blood of Toxoplasma injected mouse were most effective on yield and purity of DNA products than any other methods. 2. PCR products were relatively dependent upon the variation of MgCl_2 concentration and pH in PCR buffer. 3. As the PCR results after serial dilution, G NOME DNA isolation method from tachyzoites showed the sensitivity to 0.05 fg and the split second DNA isolation kit method showed to 5 pg. In the result, the sensitivity of PCR was increased to 10-1000 times after adding CTAB in these two methods. 4. In two steps PCR, denaturation and annealing, after adding CTAB, G NOME DNA isolation kit method showed sensitivity to 5 pg and split second DNA isolation kit method to 5 ng at the annealing of 72℃ and the former showed the sensitivity to 50 fg and the latter showed the same sensitivity with it at 72℃, at the annealing of 65℃. 5. As the result of comparison to the sensitivity of target DNA with sequntial amplification method and Southern blot hybridization, the one was 100-1000 times more sensitive than that of the other.