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RISS 인기검색어
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- 저자 : Shin Younhee (검색결과 52 건)
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Discovery of Gene Sources for Economic Traits in Hanwoo by Whole-genome Resequencing
Shin, Younhee,Jung, Ho-jin,Jung, Myunghee,Yoo, Seungil,Subramaniyam, Sathiyamoorthy,Markkandan, Kesavan,Kang, Jun-Mo,Rai, Rajani,Park, Junhyung,Kim, Jong-Joo Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.9
Hanwoo, a Korean native cattle (Bos taurus coreana), has great economic value due to high meat quality. Also, the breed has genetic variations that are associated with production traits such as health, disease resistance, reproduction, growth as well as carcass quality. In this study, next generation sequencing technologies and the availability of an appropriate reference genome were applied to discover a large amount of single nucleotide polymorphisms (SNPs) in ten Hanwoo bulls. Analysis of whole-genome resequencing generated a total of 26.5 Gb data, of which 594,716,859 and 592,990,750 reads covered 98.73% and 93.79% of the bovine reference genomes of UMD 3.1 and Btau 4.6.1, respectively. In total, 2,473,884 and 2,402,997 putative SNPs were discovered, of which 1,095,922 (44.3%) and 982,674 (40.9%) novel SNPs were discovered against UMD3.1 and Btau 4.6.1, respectively. Among the SNPs, the 46,301 (UMD 3.1) and 28,613 SNPs (Btau 4.6.1) that were identified as Hanwoo-specific SNPs were included in the functional genes that may be involved in the mechanisms of milk production, tenderness, juiciness, marbling of Hanwoo beef and yellow hair. Most of the Hanwoo-specific SNPs were identified in the promoter region, suggesting that the SNPs influence differential expression of the regulated genes relative to the relevant traits. In particular, the non-synonymous (ns) SNPs found in CORIN, which is a negative regulator of Agouti, might be a causal variant to determine yellow hair of Hanwoo. Our results will provide abundant genetic sources of variation to characterize Hanwoo genetics and for subsequent breeding.
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The Primary Process and Key Concepts of Economic Evaluation in Healthcare
Younhee Kim,Yunjung Kim,Hyeon-Jeong Lee,Seulki Lee,Sun-Young Park,오성희,Suhyun Jang,Tae-Jin Lee,Jeonghoon Ahn,Sangjin Shin 대한예방의학회 2022 예방의학회지 Vol.55 No.5
Economic evaluations in the healthcare are used to assess economic efficiency of pharmaceuticals and medical interventions such as diagnoses and medical procedures. This study introduces the main concepts of economic evaluation across its key steps: planning, outcome and cost calculation, modeling, cost-effectiveness results, uncertainty analysis, and decision-making. When planning an economic evaluation, we determine the study population, intervention, comparators, perspectives, time horizon, discount rates, and type of economic evaluation. In healthcare economic evaluations, outcomes include changes in mortality, the survival rate, life years, and quality-adjusted life years, while costs include medical, non-medical, and productivity costs. Model-based economic evaluations, including decision tree and Markov models, are mainly used to calculate the total costs and total effects. In cost-effectiveness or cost-utility analyses, cost-effectiveness is evaluated using the incremental cost-effectiveness ratio, which is the additional cost per one additional unit of effectiveness gained by an intervention compared with a comparator. All outcomes have uncertainties owing to limited evidence, diverse methodologies, and unexplained variation. Thus, researchers should review these uncertainties and confirm their robustness. We hope to contribute to the establishment and dissemination of economic evaluation methodologies that reflect Korean clinical and research environment and ultimately improve the rationality of healthcare policies.
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Shin, Kyung Rim,Kang, Younhee,Kim, Mi Young,Jung, Dukyoo,Kim, Jeong Soo,Hong, Chong Min,Yun, Eun Suk,Ma, Rye Won Blackwell Publishing Asia 2010 NURSING AND HEALTH SCIENCES Vol.12 No.4
<P><B>Abstract</B></P><P>This study determined the predictors of the fear of falling (FOF) in 213 South Korean community‐dwelling elderly. The Fall Efficacy Scale, Pittsburgh Sleep Quality Index, Korean Geriatric Depression Screening Scale, and Barthel Index were used to measure the FOF, sleep quality, depression, and activities of daily living, respectively. In addition, information regarding the participants' demographic details and the number of types of medication was collected. The data were analyzed by using hierarchical regression. The general regression model, with the FOF as a dependent variable, was statistically significant. The FOF variance was partially explained. Depression and activities of daily living significantly influenced the FOF. Thus, the results indicate that the FOF in community‐dwelling elderly Koreans is affected by depression and activities of daily living. Therefore, an older adult with recognized signs of depression must be provided with more appropriate care and the allocation of specific interventional strategies in order to maintain activities of daily living should be developed to manage the FOF.</P>
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김연희(YounHee Kim),김성완(SungWan Kim),신판섭(PanSeop Shin),이재호(Jaeho Lee),임해철(HaeChull Lim) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.2Ⅰ
웹 상의 데이터 표현 및 교환의 새로운 표준으로 인식되어 점차 그 교류의 양이 증가하고 있는 XML 문서를 효과적으로 저장, 접근 및 검색하기 위한 기법에 대한 연구가 많았으나, 기존의 연구들은 데이터중심 문서의 특성이 두드러지는 XML 문서를 대상으로 하는 것이 대부분이였다. 그러나 효과적인 XML 문서의 저장 및 검색을 위해서는 XML 문서의 실제 사용 목적이나 그 특성에 따라 XML 문서를 분류하여 각 특성에 맞는 저장, 접근 및 검색 기법을 개발하고 이를 통합한 XML 문서 저장 시스템의 개발이 요구된다. 따라서 본 논문에서는 통합 시스템 개발에서, 인간 이해 중심의 문서적 특성을 가지는 문서중심 문서를 위한 데이터 모델을 제안한다. 제안된 데이터 모델은 루트 노드가 존재하는 방향성과 순서가 있는 그래프 형태를 지원하며, XML 문서의 주요 구성 요소를 지원하는 여러 타입의 노드와 다양한 노드 사이의 관계를 표현하는 링크로 구성되어 XML 문서가 가지는 의미와 구조적 특징이 잘 표현되도록 하였다. 또한 모델링 후 손실되는 정보가 거의 없기 때문에, 다시 XML 문서로 변환하면 원래 XML 문서 그대로 복원되는 장점이 있어 문서중심 문서의 저장 및 검색을 위한 XML 저장 시스템에 적합한 데이터 모델이다.
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신경림(Shin Kyung Rim),강윤희(Kang Younhee),정덕유(Jung Dukyoo),김미영(Kim Miyoung),이에리쟈(Lee Eliza),윤은숙(Yun Eun Suk),김윤주(Kim Yun Ju),마예원(Ma,Rye Won),오승진(Oh Seung Jin) 질적연구학회 2011 질적연구 Vol.12 No.2
Purpose: This study aimed to understand the experiences of older adults participating in community exercise programs who return to the program after experiencing a fall, and to explore how their experiences changed after falling. Methods: The subjects were 15 older adults who have experienced accidental falls and have continued to participate in the programs even after falling. Data were collected from February to March 2011 through unstructured face-to-face interviews. Data analysis was using Colaizzi's phenomenological method. Results: The experiences of older adults were divided into the following six categories: "practicing exercise in order to recover from physical impairment", "having gone through trial and error to find the exercise that is right for me", "noticing physical changes as a result of exercise", "having developed confidence through exercise", "having stronger physical functions thanks to consistent exercise", and "lingering fears about recurrent falling." The subjects stated that the best strategy for overcoming their fear of recurrent falling is "to actively participate in exercise programs." Conclusion: By gradually proceeding the exercise that was right for their physical condition and refraining from being over-hasty, they experienced positive physical and emotional changes, gained confidence about their lives in old age, and developed improved physical functionality.
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