섬유가공업체 코팅 부서 근로자들의 유기용제 만성폭로에 의한 신경행동학적 수행능력의 변화

신동훈,이무식,양선희 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

The study was conducted to predict the risk of chronic exposure by neurobehavioral test and to use it as a basic source of the management for workers exposed to organic solvents. The exposed group was selected from coating department of textile processing industry. The unexposed group was selected from those who visited the clinic to take an annual check-up. The author administered WHO-NCTB (neurobehavioral core test battery). Also, Scandinavian Questionnaire 16 was tested by self-administration to find the correlation between subjective symptoms and NCTB results, and to assess the availability of the Questionnaire in mass screening test concurrently. The final analysed subjects were 78(27 in exposed group and 51 in unexposed group) workers except who had a neurologic disease or systemic disease affecting the central nervous system. In Questionnaire study, there was no significant difference in total neurotoxic symptom scores between the exposed and the unexposed group. In NCTB, the exposed group had lower mean scores than the unexposed group for all tests. When the effect by age and education were considered, there was a statistically significant difference only in pursuit aming test. This study suggests the availability of NCTB and the Questionnaire for the assessment of neurobehavioral change in workers exposed to organic solvents.

손톱 물어뜯는 환아의 특성

신윤오,황선희 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The author investigated 30 fingernail biting patients(3.0%) diagnosed by DSM-1V among 1009 patients visited child psychiatry section of Chungnam National University Hospital for 3 years and 2months. The results are asfollows: 1. The age of patients was distributed from 2 years old to 16 years old. The most frequent age range was 6-8 years old. Male /female ratio was 6.5:1(male 26, female 4). 2. The frequent associated psychiatric diagnoses were attention-deficit/hyperactivity disorder(19; 63.3%), tic disorders(6; 20.0%), oppositional defiant disorder (3명; 10.0%), conduct disorder(2; 6.7%), anxiety disorder(2; 6.7%), mental retardation(2; 6.7%). 3. The frequent associated psychiatric symptoms were inattention, hyperactivity, stealing, tic. 4. The main psychiatric treatment were counseling(14'11,1: 46.7%), imipramine(7: 23.3%). methylphenidate (411,41 ; 13.3%), haloperidol(2: 6.7%).

신경인성 방광의 치료에서 요도부목 설치의성공례와 실패례 -증례 보고-

임선희,나은우,이일영,문혜원,임신영,정도영 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.1

핸드볼 페널티드로우 시 숙련자와 비숙련자 간의 시각적 변이 비교 분석

한재희,박영민,신선미,이준희,심윤식 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2

The purpose of this study is to analyze the visual variation of skilled and unskilled people, and to obtain data necessary for skill improvement of effective handball penalty throw. An eye tracker was used to collect eye movements, concentration points, directions, and paths during penalty throws. The results are as follows: 1) For skilled players, the place where they threw and the place where their eyes were focused matched. 2) There is no difference in the presence or absence of eye contact with the goalkeeper.

지역사회 거주 노인에서 장애 변화의 예측인자

신희영,신일선,김재민,김성완,양수진,윤진상 대한신경정신의학회 2008 신경정신의학 Vol.47 No.2

Objectives : This study aimed to identify the predictors for change in disability measured by the Korean version of World Health Organization Disability Assessment Schedule II (WHODAS II-K) m community-dwelling elderly population. Methods : Of 1204 community participants aged 65 years or over, 717 were reevaluated by WHODAS II-K 2 years later. At baseline, information on demographic characteristics (age, gender, living area, marital status, and religion), socioeconomic status (education, type of accommodation, number of rooms, previous occupation, current employment, and social network), and clinical characteristics (number of physical illness, depression by the Korean version of Geriatric Mental State Schedule B3, and cognitive impairment by Korean version of Mini-Mental State Examination) were collected. Results : Scores on the WHODAS II-K increased by 17.5 in 2 years. Age (B coefficient 0.52, 95% CI : 0.21~0.84), number of rooms (B coefficient -1.92, 95% CI : -3.53~-0.30), and depression (B coefficient 1.84, 95% CI : 0.43~3.25) were independently significant predictors for change in disability. Conclusion : Change in the level of disability measured by the WHODAS II-K was mainly affected by age, number of rooms, and depression. These results can be useful for the development of community-based health promotion program for the elderly.

지역사회 거주 저소득층 노인의 우울증상 유병률과 관련인자

신희영,이훈,신일선,김재민,김성완,양수진,윤진상 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5

Objectives : This study aimed to investigate the prevalence and correlates of depressive symptoms in community-dwelling low income elderly. Methods : A community survey of 1,351 low income residents aged 65 or over was conducted in Buk district of Gwangju, Korea. Depressive symptom was evaluated by the Korean Form of the Geriatric Depression Scale (KGDS). Their Sociodemographic factors, the precence of chronic physical illness, and cognitive functions were investigated. Results : The prevalence rate of depressive symptoms was 69.8%. In multiple logistic regression, chronic physical illness (Odds Ratio : 2.68, 95% Confidence Interval : 1.98-3.63), low education (Odds Ratio : 1.84, 95% Confidence Interval : 1.39-2.43), and cognitive impairment (Odds Ratio : 1.61, 95% Confidence Interval : 1.20-2.16) were independently associated with depressive symptoms. Conclusion : Depressive symptoms in community-dwelling low income elderly were very common, particularly related to current chronic physical illnesses. The results of this study can be useful for the development of community-based prevention and management programs for depression. Of elderleg.

카드뮴이 인간 단핵구 세포주(THP-1)에서 cytokine 유전자 발현에 미치는 영향

신동훈,박관규,강미정,서석권,정인성,양선희 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2

Cadmium, a potent toxic metal, posses a serious environmental threat but the mechanism of its toxicity remains unclear. Also, cadmium is a known immunotoxic agent in animal studies and induces pathophysiological effects by modulating components of immune system. Cytokines are being increasingly recognized as essential mediators of normal and pathologic immune response. Cells of mononuclear phagocytic system are strategically located at portals of entry in humans and therefore may be particularly at risk for cadmium exposure through contaminated air, food, and drinking water. In the present study, we investigated the effect of cadmium cytotoxicity for the monocyte and expression of cytokine gene in the control and cadmium treated human monocytic cell lines using RT-PCR method. The results showed that cadmium inhibited cell proliferation at 0.1mM cadimium treated cells for 24 hours. The TNF-α mRNA was expressed in both control and cadmium treated cells but not IL-6 and IL-1β. The mRNA levels of TNF-αwere examined during 24 hours culture period, at different time points. The expression of TNF-αmRNA increased in both 0.01mM and 0.1mM cadmium treated cells, but did not show dose-response relationship. According to cadimium treated duration, expression of TNF-αmRNA was more decreased in 24 hours than 6 hours. The decreased levels of mRNA of TNF-α suggest that cadmium suppresses its production at the transcription level.

운동을 통한 체중조절 프로그램에 의한 식이섭취량과 혈청지질 분포의 변화

신혜준,김희선 순천향대학교 기초과학연구소 2001 순천향자연과학연구 논문집 Vol.7 No.2

The purpose of this study was to investingate how regular exercise program affects on physical fitness and changes of body fat(%) and serum lipid profiles of female university students. Twelve students were recruited and 7-week exercise program was conducted at least 3 days per week for 40 minutes. The body weight and body fat changes were measured during exercise program. Changes of dietary intake and serum lipid profiles were monitored before and after excercise program. The results were as follows. 1. After regular exercise, weight and body fat(%) was reduced significantly (1.12kg,1.6%, p<0.01) 2. High-density lipoprotein concentration was significantly (p<0.01) increased and triglyceride level was reduced significantly (p<0.01) while total cholesterol and low-density lipoprotein concentration did not show significant changes after the exercise program. 3. After exercise program, better nutritional intake pattern was observed. In summary, regular excercise program showed positive effects on decrease of body weight, body fat and serum lipid profiles as well as dietary intakes.

Dissolved Air Flotation(DAF) 접촉조의 수리동력학적 조건이 입자의 제거에 미치는 영향

유제선,김성훈,신은허,박희경 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

Hydrodynamic conditions for optimum solids capture within the contact zone, which are governed by the geometry and flow, are not yet well understood. In this research, dimensionless parameters which represent hydrodynamic conditions in the contact zone were derived, using the Buckingham π theorem. Those parameters are Reynolds No. (Re), Froude No. (Fr), Weber No. (We), Local Weber No., and Bubble Capacity No. (Bc). The particle removal rate was investigated by changing each value of the dimensionless parameters. The experimental results indicate that particle removal rate, when gravity dominates and the flow is semi-turbulent (Fr < 0.3, Re < 8000), is higher than when inertia dominates and flow is turbulent. For the We, higher removal rates were obtained in the range of the We < 40. Relative to the Local We, smaller bubbles which are influenced more by surface tension than inertia, demonstrated a higher particle removal rate than larger bubbles. For the Bc, the optimal range is from 0.3 to 0.5. We suggest that these dimensionless parameters can be used to diagnose the performance of and to design a DAF reactor.

납에 의해 유발된 신경세포의 APOPTOSIS

양선희,신동훈,백원기 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2

Lead is a major environmental and occupational neurotoxicant. It has been shown that long-term exposure to a low level of lead impairs the development of brain. For example, it was reported that lead exposure during the childhood causes a learning difficulty and a memory deficit of children. Neurotoxic agents including the lead are believed to cause neuronal death in developing brain by two mechanisms: apoptosis and necrosis. However, the exact mechanism of neuronal death caused by lead exposure is still not known explicitly. In this study, we conducted a study to clarify a mechanism of hippocampal neuronal cell death caused by lead acetate. Hippocampal neurons were cultured for 14-16days and treated with lead acetate of 1, 10, 100μM concentrations for 12 hours. With the MTT (methyl tetrazolium test)kit, the viability of neuronal cells was measured. Next, in order to examine apoptosis caused by lead acetate, TUNEL(TdT-mediated d-UTP Nick End Labelling ) assay was performed. It has been shown that lead acetate reduced the viability of neuronal cells in a dose dependent manner, especially at the concentration of 100 μM lead acetate. TUNEL immunostain showed brownish signals in the nucleus of apoptotic cells. The proportions of apoptotic cells in the lead-acetate treated group were more higher than those in the controls and increased as lead acetate concentration increased. From above results, it may be concluded that lead in the hippocampal neuronal cells reduced cell viability and one of mechanisms in neuronal cell death by lead appears to be apoptosis.