Effect of Al and Mg Contents on Wettability and Reactivity of Molten Zn–Al–Mg Alloys on Steel Sheets Covered with MnO and SiO2 Layers

Joo‑Youl Huh,Min‑Je Hwang,Seung‑Woo Shim,Tae‑Chul Kim,Jong‑Sang Kim 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.6

The reactive wetting behaviors of molten Zn–Al–Mg alloys on MnO- and amorphous (a-) SiO2-covered steel sheets wereinvestigated by the sessile drop method, as a function of the Al and Mg contents in the alloys. The sessile drop tests werecarried out at 460 °C and the variation in the contact angles (θc) of alloys containing 0.2–2.5 wt% Al and 0–3.0 wt% Mg wasmonitored for 20 s. For all the alloys, the MnO-covered steel substrate exhibited reactive wetting whereas the a-SiO2-coveredsteel exhibited nonreactive, nonwetting (θc > 90°) behavior. The MnO layer was rapidly removed by Al and Mg contained inthe alloys. The wetting of the MnO-covered steel sheet significantly improved upon increasing the Mg content but decreasedupon increasing the Al content, indicating that the surface tension of the alloy droplet is the main factor controlling its wettability. Although the reactions of Al and Mg in molten alloys with the a-SiO2 layer were found to be sluggish, the wettabilityof Zn–Al–Mg alloys on the a-SiO2 layer improved upon increasing the Al and Mg contents. These results suggest that thewetting of advanced high-strength steel sheets, the surface oxide layer of which consists of a mixture of MnO and SiO2,withZn–Al–Mg alloys could be most effectively improved by increasing the Mg content of the alloys.

정신과 영역에서의 신경펩타이드 자극검사

심주철,김용관 대한생물치료정신의학회 1995 생물치료정신의학 Vol.1 No.2

Many interesting concepts and hypothesis have been advanced with regard to functional role of neuropeptide in psychiatric field. Although the findings of neuropeptide test in psychiatric disorder have helped to elucidate pathophysiological mechanism, they have not provided us with a suitable biological marker. There are no consistent findings for any of neuropeptide challenge test that we haved discussed in terms of their value in differentiating between psychiatric disorders. But many findings have proved to be more valuable as a measure of pathophysiology and as a correlated of treatment response and illness course than a biological marker of the illness. There is a definite need for continuing study in neuropeptide itself, factors influencing neuropeptide, as well as a need to definite underlying genetic processes.

만성 정신분열병 환자에서 지연성 운동장애와 음성증상 및 인지기능 장애와의 연관성

심주철,반철식,성기수,이정구,정도운,정청,윤진상,김영훈 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

연구목적: 정신과 전문병원에 입원해 있는 만성정신분열병 환자들을 대상으로 첫째 지연성 운동장애의 유병율과 위험인자들을 조사하고, 둘째 지연성 운동장애와 정신분열병의 음성증상 및 인지기능 장애와의 상관성을 조사하고자 한다. 방법: 연구대상자는 마산동서병원에 입원 중인 환자 중 DSM-IV의 정신분열별 진단기준에 부합하며, 최근 3개월 이상 동일 용량의 항정신병약물 복용한 271명(남자 174명, 여자 97명)의 환자들이었다. 지연성 운동장애에 대한 평가는 Abnormal Involuntary Movement Scale(AIMS)을 이용하였고, DSM-IV와 Sc-hooler와 Kane(1982)의 진단기준 양자에 부합하는 환자들만을 지연성 운동장애군으로 분류하였다, 정신 분열병 정신병리에 대한 평가는 Brief Psychiatric Rating Scale(BPRS)와 Schedule for the Deficit Syndrome(SDS)을 이용하였고, 인지기능에 대한 평가는 Mini-Mental Status Examination(MMSE)을 이용하였다. 결과: 지연성 운동장애의 유병율은 50.9%이었고, 50세 이상, 남자에서 높았다. 그러나 입원기간과 항정신병 약물의 일일 사용량에 따른 차이는 없었다. 지연성 운동장애의 호발부위는 혀, 상지, 입술과 입 주위의 순이었다. BPRS 총점 및 소항목 척도점수와 SDS 척도점수는 지연성 운동장애의 유무에 따른 차이가 없었다. MMSE 총점 및 소항목 점수도 지연성 운동장애의 유무에 따른 차이가 없었다. 결론: 평균입원기간이 9년 이상인 만성정신분열병 환자들에게서의 지연성 운동장애의 유병율은 50.5%이었고, 연령이 가장 의미있는 위험인자임을 확인했다. 만성정신분열병 환자들이 주 대상인 본 연구에서는 지연성 운동장애와 정신분열병의 음성증상 및 인지기능 장애와의 상관성은 입증하지 못했다. Objectives: The purpose of present study was to determine the prevalence rate of tardive dyskinesia and to search for its risk factors in chronically institutionalized schizophrenic subjects. We also examined the relationship between tardive dyskinesia and both negative symptoms and cognitive impairments in the same subjects. Methods: Subjects were 271 in-patients(174 males, 97 females) at Masan Dongsuh Hospital. They met DSM-IV criteria for schizophrenia and had been taking fixed doses of antipsychotics for at least 3 months. Tardive dyskinesia was assessed by Abnormal Involuntary Movement Scale(AIMS). Cases of tardive dyskinesia were ascertained by the criteria of Schooler and Kane (1982) and DSM-IV. The rating of psychopathology was acquired using Brief Psychiatric Rating Scale(BPRS) and Schedule for the Deficit Syndrome(SDS) and the assessment of cognitive function using Mini-Mental State Examination(MMSE). Results: The prevalence of tardive dyskinesia is 50.9% and the frequency of tardive dyskinesia was high est in male above the age of fifty. But there was no statistically significant relationship between the frequency of tardive dyskinesia and both the length of hospitalization and the daily dose of antipsychotics. The frequency order of abnormal movement in the patients with tardive dyskinesia was as follows : tongue, upper extremities, lips and perioral area. We couldn't find any significant difference in the total and subscale scores of BPRS between the groups with and without tardive dyskinesia. There were no differences in MMSE scores between the groups with and without tardive dyskinesia. Conclusion: This study gave us that the prevalence of tardive dyskinesia was high in chronically institutionalized schizophrenic inpatients and that age was the most significant risk factor of tardive dyskinesia. The relationship between tardive dyskinesia and both negative symptoms and cognitive impairment, however, was not revealed.

정신분열병 환자의 우울증에서 Paroxetine과 삼환계 항우울제 병용치료

심주철,공보금,박정환,윤영란,신재국,김정익,안동성,김용관,차인준,김영훈 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.4

저자들은 마산동서병원에 입원중인 우울증이 동반된 정신분열증 환자 10명을 대상으로 사용중인 항정신병약물에 paroxetine과 저용량의 삼환계 항우울제를 6주간 병용투여한 후 우울증상에 대한 효과와 치료의 안전성 및 약물상호작용을 알아보았다. Paroxetine은 고정량의 항정신병약물과 삼환계 항우울제에 부가하여 일일 20㎎을 6주간 병용하게 하였으며, 임상상태는 HDRS, HARS, UKU Side Effect Rating Scale등의 평가척도를 사용하여 평가하였다. 또한 약동학적 약물상호작용은 삼환계 항우울제들의 혈장농도를 HPLC로 측정하여 분석하였다. 결과는 다음과 같다. 1) 10명의 전체 대상환자에서의 HDRS 평균점수는 TCA와 paroxetine 병용투여 6주후에 통계적으로 유의하게 감소되었다. 이중 40%의 환자에서는 병용투여 6주후에 HDRS 점수상 50% 이상의 감소를 보여, 일부의 환자들에서는 정신분열병에 동반된 우울증상의 치료에 소량의 삼환계 항우울제와 paroxetine의 병용치료가 효과가 있음을 확인하였다. 2) 두 명의 환자에게서 심각한 약물독성이 발생하였다. 이중 한 명은 삼환계 항우울제의 높은 혈중농도로 인한 항콜린성 위기(anticholinergic crisis) 소견을 보였으며, 다른 한 명은 인지기능 및 의식수준은 명료하였으나 망상과 환각증상이 약화되는 소견을 보였다. 따라서 본 연구에서 시도된 복합적 약물치료의 경우, 삼환계 항우울제의 혈중농도의 측정을 포함한 세심한 임상적 추적이 필요하다고 생각된다. 3) 기저치의 amitriptyline과 그 대사물인 nortriptyline의 농도합. imipramine과 대사물인 desipramine의 농도합은 각각 47.8-226.5ng/㎖. 80.5-395.6ng/㎖였으며 일반적으로 이들 약물들의 단독사용시에 문헌에 보고된 혈중농도를 훨씬 상회하고 있었다. 이는 병용투여된 항정신병 약물 약시 강력한 CYP2D6 효소억제제로서 기저치의 삼환계 항우울제들의 혈장농도를 이미 상당히 증가시켰던 것으로 판단되며, 그러한 결과로 인해 본 연구에서는 paroxetine이 이전의 문헌보고들과는 달리 뚜렷하게 삼환계 항우울제들의 혈장농도를 증가시키지 못하였다. 본 연구는 SSRI와 삼환계 항우울제의 병합 투여가 우울증의 개선 효과를 빠르게 하고, 치료역을 넓히고, 약물상호작용의 결과 paroxetine이 삼환계 항우울제의 혈중농도를 증가시킨다는 기존의 연구결과를 이용하여 정신분열병 우울증상의 치료에 parotextine과 소량의 삼환계 항우울제를 병용하는 방법을 시도해 본 연구이다. 저자들은 이러한 약물치료가 일부의 환자들에게서 효과가 있음을 관찰하였으나, 항정신병약물과 삼환계 항우울제를 병용투여 할 경우는 물론 이에 paroxetine과 같은 선택적 세로토닌 재흡수 억제제를 병용할 경우 복합약물상호작용의 결과로 약물독성의 위험성이 크며 세심한 주의가 필요함을 경험하였다. Depression is well-known to comorbid with several psychiatric disorders. Many schizophrenics also suffer from depression in the course of their illness. Combined therapy of SSRI and tricyclic antidepressants were reported to have benefits in some depressed patients. Paroxetine, a potent CYP2D6 inhibitor, increases the blood levels of tricyclic antidepressant markedly. Using paroxetine, we tried this combined therapy in the treatment of depressive symptoms in 10 chronic schizophrenic inpatients and evaluated its efficacy and drug interactions between paroxetine and tricyclic antidepressants. The following results were obtained : 1) The mean score of Hamilton's Depression Rating Scale(HDRS) was reduced significantly after 6 weeks-trials of this combined therapy for the mild depressive symptoms in 10 chronic schizophrenics. In four patients, 50% or more reductions in the scores of HDRS were noticed at final evaluation. 2) Two among our 10 subjects experienced severe toxic behavioral problems. Anticholinergic crisis with toxic confusion due to high blood levels of tricyclics was found in one patient and the other showed rapid clinical deterioration in his psychotic symptoms such as delusion and hallucination without any consciousness alternation. 3) Baseline plasma levels of tricyclics before adding paroxetine were higher than expected in our chronic schizophrenic subjects maintained with their antipsychotic medications. Several antipsychotics were also known as a potent CYP2D6 inhibitors and to increase the blood levels of tricyclics. Because the blood levels of tricyclics had already increased significantly by the use of antipsychotics, adding paroxetine to antipsychotics and tricyclic antidepressant in our subjects could increase the blood levels of tricyclics not so much as previously reported in the literatures.

Developmental Characteristics of SCNT Pig Embryos Knocked-out of Alpha-1,3-Galactosyltransferase Gene

Joo-Hyun Shim1,Mi-Rung Park,Byoung-Chul Yang,Yeoung-Gyu Ko,Keon Bong Oh,Jeong-Woong Lee,Jae-Seok Woo,Eung-Woo Park,Soo-Bong Park,Seongsoo Hwang 한국동물번식학회 2009 Reproductive & developmental biology Vol.33 No.3

두부 외상후의 정신장애에 대한 임상적 연구

심주철,박태수,진성태 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.1

This study was performed to investigate the clinical characteristics of the psychiatric disabilities associated with head injury. The subjects were 53 patients who had been admitted to the Pusan Paik Hospital. In je University from Jan. 1986 to Dec. 1990 with the problem of mental symptoms following head injury. The results were summarized as follows : 1) The incidence of psychiatric disability following head injury was higher in male(81.1%). socially-active age group, relatively low educational level, and low socio-economic class. 2) Traffic accident occupied the main cause of head injury, and in the aspect of degree of head injury, cerebral contusion (56.6%) was higher than cerebral concussion (43.4%). 3) In the aspect of premorbid personality, without overt premorbid personality disorder was 49.0%. dependent personality was 9.4%, compulsive personality was 7.5%, and passiveaggressive personality was 7.5%. 4) Posttraumatic neurosis(39.6%) was the most frequent diagnosis, and organic personality syndrome was 22.6%, dementia & amnestic syndrome was 15.1%. organic delusional & hallucinosis was 7.5 %, posttraumatic epilepsy was 5.7 %, organic affective syndrome was 3.8%. 5) EEG & brain CT findings were normal in 60.4% of subjects, and cases of neurosurgical non-operative subjects(81.1 %) were more frequent than operative subjects (18.9%). 6) Mean duration of interval period(duration from head injury to psychiatric treatment), admission period, out-patient period was 105.5. 145.2. 155.0 days respectively, and out-patient period was significantly longer in subjects of organic personality syndrome, posttraumatic neurosis, and posttraumatic epilepsy (p<0.05). 7) Correlation between interval period and out-patient period was positively correlated(r=0.4394. p=0.001).

알콜리즘에서 Buspirone에 대한 Cortisol과 Prolactin 반응

심주철,이정구,김정익,이유철,김영훈 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

연구목적: 본 연구는 buspirone에 대한 cortisol과 prolactin 반응을 통해 알콜리즘에서 5-HT1A 수용체기능을 조사하고자 하였다. 방법: 알콜리즘 환자군은 DSM-IV의 알콜리즘 진단기준에 부합되고 금주기간이 최소 3개월 이상이며 우울 및 불안증상이 없는, 한 정신병원 알콜 센터에 입원한 22명의 남자 환자였다. 대조군은 정상성인 남자 15명이었다. 이들에게 오전 9시에 5-HT□ 효현제인 buspirone 30mg을 경구 투여한 후 0, 30 , 60, 90, 120, 150분의 혈청 cortisol과 prolatine 농도를 측정한다. 결과: 환자군과 대조군간에 cortisol 기저치에는 유의한 차이가 없었다. Buspirone 투여 후 혈청 cortisol 농도는 정상대조군에서는 기저치에 비해 유의한 증가를 보였으나(p<0.01) 환자군에서는 유의환 증가가 없었다. 혈중 cortisol 농도는 buspiron 투여 60분 이후부터 환자군에서 정상 대조군에 비해 유의하게 저하되어 있었다(p<0.05). Buspirone에 대한 혈청 prolactin 반응은 환자군과 정상대조군간에 유의한 차이가 없었다. 결론: Buspirone 투여 후 둔마된 혈청 cortisol 반응을 통해 알콜리즘에 5-HT1A 수용체 반응성이 둔마되어 있음을 확인할 수 있었다. Objectives: The purpose of this study was to evaluate the prolactin and cortisol responses to 5-HT1A receptor activation by buspirone in alcoholics. Methods: The subjects were twenty two male alcoholic patients meeting the DSM-IV criteria for alcohol dependency and abstaining for more than 3 months. Patients were free from overt anxiety and depressive symptoms. Controls were fifteen male normal volunteers, with no psychiatric and medical illness. Blood samples for the measurement of serum cortisol and prolactin levels were drawn 0, 30, 60, 90, 120, 150 minutes after oral administration of 30mg buspirone hydrochloride at 9:00a.m. Results: The baseline cortisol levels were not significantly different between alcoholics and controls. Serum cortisol levels of controls after buspirone administration were significantly increased over time(p<0.01), but those of alcoholics did not increased. After 60 minutes following buspirone administration, cortisol levels were significantly lower in alcoholics than in contrlos(p<0.05). Prolactin responses to buspirone were not significantly different between the two groups. Conclusions: Our results suggested that 5-HT1A receptor function is decreased in alcoholic patients.

불안의 형성과정에 있어서 뇌 Cholecystokinin의 역할

김영훈,심주철 대한생물치료정신의학회 1995 생물치료정신의학 Vol.1 No.2

Cholesystokinin(CCK) is one of the most abundant neuropeptides and its receptors are widely distributed throughout the central nervous system, especially in hypothalamus, limbic system, basal ganglia, hippocampus and cortex. CCK is co-localized or interacts with dopaminergic, noradrenergic, GABAergic and serotonergic neurotransmitter systems. lts functional roles are not fully defined, but it appears to mediate anxiety and it may participate in satiety, nociception and drug withdrawal. CCK/dopamin neurons in ventral tegmental area project their long pathways to limbic system and striatum and their roles in the pathogenesis of dopamine-related disorders such as schizophrenia are shortly described in this article. Cholecystokinin tetrapeptide(CCK-4) is suggested to have a potent panicogenic property in human. Both clinical and animal research suggests that ?? receptors mediate the panicogenic effects of CCK-4 and their antagonists provide an important advance in the treatment of anxiety disorder. The possible involvement of CCK in the pathogenesis of panic disorder is described briefly. The antagonistic action of imipramine on CCK-4-induced panic and that of 5-HT₃ on CCK release in nucleus accumbens are discussed. As described above, there is growing speculations that CCK might be implicated in the neurobiology of anxiety and its receptor agonists could be used in the treatment of anxiety in future.

이갈이 환자의 다면적 인성검사의 특성

박병욱,이희철,장문정,심주철 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.3

연구목적 : 다면적 인성검사를 통해 이갈이군의 심리적 특성을 알아보고 이갈이 환자의 성별, 가족력, 발병기간, 이갈이 유형, 동반된 통증 유무에 따른 심리적 특성의 차이를 알아보고자 하였다. 방 법 : 1998년 1월부터 8월까지 개인 치과의원을 방문한 환자들 중 46명의 이갈이군, 41명의 대조군을 대상으로, 이갈이군과 대조군의 심리적 특성, 이갈이 환자의 성별, 가족력 유무, 이갈이 기간, 이갈이 유형, 통증과 같은 동반증상유무에 따른 심리적 특성의 차이를 알아보기 위해 다면적 인성검사를 실시하였다. 결 과 : 이갈이군이 대조군보다 모든 임상척도에서 높은 점수를 나타냈으나 남성특성-여성특성 척도점수를 제외하고는 통계적 유의성이 없었다. 가족력이 있는 이갈이군이 가족력이 없는 이갈이군보다 반사회성 척도가 높았다. 이갈이군에서 남자가 여자보다 교정척도(K) 점수가 높게 나타났으며 여자는 편집증 척도점수가 높게 나타났다. 발병기간에 따른 차이는 없었으며 이갈이 종류의 비교에서는 이악물기형이 다른형보다 내향성 척도가 유의하게 높았다. 저작근 통증, 경통, 두통과 같은 동반된 통증 유무에 따른 차이는 없었다. 결 론 : 다면적 인성검사상 일부 항목에서 높은 점수를 나타낸 것으로 이갈이 환자의 심리적 특성을 규정짓기는 어려우나 이갈이군이 대조군에 비해서 다면적 인성검사상 모든 척도가 상승되어 있고, 이갈이의 성별, 가족력, 이갈이의 종류에 따라 일부 척도의 점수가 상승되어 있는 것은 이들이 서로 다른 심리적 특성을 가질 가능성을 시사한 것이라고 판단되며, 이는 치료에 있어서도 좀 더 개별화된 접근이 필요함을 시사한다. Objectives : The aim of this study was to evaluate the psychological characteristics of the patients with bruxism by Minnesota Multiphase Personality Inventory (MMPI). Methods : MMPI was administered to 87 patients(46 bruxism group and 41 control group) who had visited a local dental clinic from January to August 1998. Results : The bruxism group had a higher score than control group in Masculinity-Femininity (Mf) scale. There were no differences between bruxism group and control group on the distribution of Depression(D), Psychopatic Deviate(Pd), Paranoia(Pa), Psychasthenia(Pt) scales. The bruxism group with the family history showed higher score than the bruxism group without family history in Pd scale. Male bruxism group had a higher score than female bruxism group in Defensiveness(K) scale and female bruxism group had higher score than male bruxism group in Pa scale. The bruxism group of clenching type had a higher score than the bruxism group of mixed type in Social Introversion(Si) scale. There were no differences in MMPI score between those who had and did not have symptoms such as masticatory muscle pain, neck pain, and headache. Conclusion : It is concluded that individualized approach may be effective to the evaluation of psychological disturbances which might be related to sex, family history and, type of bruxism, while we did not find significant differences in personality characteristics between the bruxism and control groups.

Investigative Reporting of the Park Jong Chul Case and Implications for South Korea`s Democratization

Shim, Jae-Chul,Charles T. Salmon,Lee, Kyung-Sook,Lee, Jae-Kyung,Kim, Joo-Han,Kim, Shin-Dong 한국언론학회 2001 韓國 言論學報 Vol.45 No.영문특별