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- 저자 : Shijie Xin (검색결과 3 건)
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Jiao Wu,Shan Zhao,Xin Chen,Yuanda Jiu,Junfeng Liu,Jinglin Gao,Shijie Wang 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.13
Honey quality is in relation to botanical origin, and physicochemical properties, elemental composition, and antioxidant activity have been used for assessment and identification of honeys. The goal of this study is to contribute to the general analysis of five unifloral honeys from Cocos nucifera L., Dalbergia benthami Prain, Bombax ceiba L., Castanea mollissima Bl., and mangrove in Hainan province, China. Our results revealed that B. ceiba honey had the highest pH (4.27), color (139.33 mm Pfund), ash content (1.03 g/100 g), and electrical conductivity (1312.00 μS/cm) in five unifloral honeys. Furthermore, B. ceiba honey also contained the highest levels of total phenolic content (75.54 mg GAE/100 g) and total flavonoid content (29.22 mg RE/100 g), as well as the strongest antioxidant activity (DPPH IC50 value, 3.97 mg/mL; FRAP value, 6527.43 µmol TE/kg). Moreover, we revealed a considerable variation in element contents in honeys using ICP-MS, with potassium being the most predominant element. B. ceiba honey had the highest contents of K, Ca, Mg, and P, whereas the highest amount of Na was found in mangrove honey. Overall, our data indicated that B. ceiba honey deserves further research as a potential antioxidant agent.
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ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer
( Xiaokun Wang ),( Yan Xia ),( Chentong Xu ),( Xin Lin ),( Peng Xue ),( Shijie Zhu ),( Yun Bai ),( Yingyu Chen ) 생화학분자생물학회 2017 BMB Reports Vol.50 No.8
The endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 human adenocarcinoma gastric cancer cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored. [BMB Reports 2017; 50(8): 411-416]
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Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graft Restenosis
Yugang Li,Lei Wang,Shanshan Chen,Dan Yu,Weifeng Sun,Shijie Xin 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.5
Purpose: To explore the effects of biodegradable magnesium alloy stents (BMAS) on remodeling of vein graft (VG) anastomoticrestenosis. Materials and Methods: To establish a VG restenosis model, seventy two New Zealand rabbits were randomly divided into threegroups according to whether a stent was implanted in the graft vein or not. BMASs and 316L stainless steel stents were implantedin BMAS and 316L groups, respectively, while no stent was implanted in the no-treatment control group (NC group). Loss of lumendiameter in the graft vein was measured in all three groups. Upon harvesting VG segments to evaluate intimal proliferationand re-endothelization, the degradation and biological safety of the stents were observed to explore the effects of BMAS on VGremodeling. Results: Model establishment and stent implantation were successful. The BMAS reduced lumen loss, compared with the controlgroup (0.05±0.34 mm vs. 0.90±0.39 mm, p=0.001), in the early stage. The neointimal area was smaller in the BMAS group than the316L group after 4 months (4.96±0.66 mm2 vs. 6.80±0.69 mm2, p=0.017). Re-endothelialization in the BMAS group was better thanthat in the 316L group (p=0.001). Within 4 months, the BMAS had degraded, and the magnesium was converted to phosphorusand calcium. The support force of the BMAS began to reduce at 2–3 months after implantation, without significant toxic effects. Conclusion: BMAS promotes positive remodeling of VG anastomosis and has advantages over the conventional 316L stents in thetreatment of venous diseases.
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