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- 저자 : Shi Jesse Liu (검색결과 2 건)
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Terminalia arjuna Bark and inotropic therapy for heart failure
Shi Jesse Liu 셀메드 세포교정의약학회 2012 TANG Vol.2 No.3
Heart disease that ultimately leads to heart failure (HF) has been the number one cause of death in the United States as well as in many other countries for over a century. Inotropic therapy utilizing cardiotonics to increase cardiac contractility remains a significant component of the management of HF. However, adverse effects of currently available cardiotonics have been compromising their therapeutic value and often lead to further myocardial dysfunction. Thus, discovery of safe cardiotonics remains a main challenge to improvement of inotropic therapy for HF. This review briefly summarized cellular mechanisms underlying the inotropic action of currently available cardiotonics, newly-developed carditonics and the bark of Terminalia arjuna (TA), a tropical tree used in ayurvedic medicine. The potential of TA bark as a new cardiotonic in inotropic treatment for HF was also discussed.
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Observation of the Dirac fluid and the breakdown of the Wiedemann-Franz law in graphene
Crossno, Jesse,Shi, Jing K.,Wang, Ke,Liu, Xiaomeng,Harzheim, Achim,Lucas, Andrew,Sachdev, Subir,Kim, Philip,Taniguchi, Takashi,Watanabe, Kenji,Ohki, Thomas A.,Fong, Kin Chung American Association for the Advancement of Scienc 2016 Science Vol.351 No.6277
<P><B>Electrons that flow like a fluid</B></P><P>Electrons inside a conductor are often described as flowing in response to an electric field. This flow rarely resembles anything like the familiar flow of water through a pipe, but three groups describe counterexamples (see the Perspective by Zaanen). Moll <I>et al.</I> found that the viscosity of the electron fluid in thin wires of PdCoO<SUB>2</SUB> had a major effect on the flow, much like what happens in regular fluids. Bandurin <I>et al.</I> found evidence in graphene of electron whirlpools similar to those formed by viscous fluid flowing through a small opening. Finally, Crossno <I>et al.</I> observed a huge increase of thermal transport in graphene, a signature of so-called Dirac fluids.</P><P><I>Science</I>, this issue p. 1061, 1055, 1058; see also p. 1026</P><P>Interactions between particles in quantum many-body systems can lead to collective behavior described by hydrodynamics. One such system is the electron-hole plasma in graphene near the charge-neutrality point, which can form a strongly coupled Dirac fluid. This charge-neutral plasma of quasi-relativistic fermions is expected to exhibit a substantial enhancement of the thermal conductivity, thanks to decoupling of charge and heat currents within hydrodynamics. Employing high-sensitivity Johnson noise thermometry, we report an order of magnitude increase in the thermal conductivity and the breakdown of the Wiedemann-Franz law in the thermally populated charge-neutral plasma in graphene. This result is a signature of the Dirac fluid and constitutes direct evidence of collective motion in a quantum electronic fluid.</P>
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