Effects of N-Acetylcysteine on Nicotinamide Dinucleotide Phosphate Oxidase Activation and Antioxidant Status in Heart, Lung, Liver and Kidney in Streptozotocin-Induced Diabetic Rats

Shaoqing Lei,Zhengyuan Xia,Huimin Liu,Hong Yu,Hui Wang,Yanan Liu 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.2

Purpose: Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress plays a key role in the pathogenesis of diabetic complications. Nicotinamide dinucleotide phosphate (NADPH) oxidase is one of the major sources of ROS production in diabetes. We, therefore, examined the possibility that NADPH oxidase activation is increased in various tissues, and that the antioxidant N-acetylcysteine (NAC) may have tissue specific effects on NADPH oxidase and tissue antioxidant status in diabetes. Materials and Methods: Control (C) and streptozotocin-induced diabetic (D) rats were treated either with NAC (1.5 g/kg/day) orally or placebo for 4 weeks. The plasma, heart, lung, liver, kidney were harvested immediately and stored for biochemical or immunoblot analysis. Results: levels of free 15-F2t-isoprostane were increased in plasma, heart, lung, liver and kidney tissues in diabetic rats, accompanied with significantly increased membrane translocation of the NADPH oxidase subunit p67phox in all tissues and increased expression of the membrane-bound subunit p22phox in heart, lung and kidney. The tissue antioxidant activity in lung, liver and kidney was decreased in diabetic rats, while it was increased in heart tissue. NAC reduced the expression of p22phox and p67phox, suppressed p67phox membrane translocation, and reduced free 15-F2t-isoprostane levels in all tissues. NAC increased antioxidant activity in liver and lung, but did not significantly affect antioxidant activity in heart and kidney. Conclusion: The current study shows that NAC inhibits NADPH oxidase activation in diabetes and attenuates tissue oxidative damage in all organs, even though its effects on antioxidant activity are tissue specific.

Molecular design of a wide-band-gap conjugated polymer for efficient fullerene-free polymer solar cells

Liu, Delong,Yang, Bei,Jang, Bomee,Xu, Bowei,Zhang, Shaoqing,He, Chang,Woo, Han Young,Hou, Jianhui The Royal Society of Chemistry 2017 ENERGY AND ENVIRONMENTAL SCIENCE Vol.10 No.2

<P>Two p-type conjugated polymers with disparate optical and electronic properties, PB3T and PB2T, were developed and applied in fullerene-free polymer solar cells (PSCs). The photovoltaic performance of the PB3T-based PSC device processed by anisole achieved a high power conversion efficiency of 11.9% with a <I>J</I>sc of 18.8 mA cm<SUP>−2</SUP> and <I>V</I>oc of 1.00 V.</P>

Behavior of mercury release during thermal decomposition of coals

Shaoqing Guo,Yong Xiao,Jianli Yang,Zhenyu Liu 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.2

The mercury release behavior during thermal decomposition of three Chinese coals with different types was studied under nitrogen, carbon dioxide and air at temperatures of 800, 900, 1,000 and 1,100℃. The thermal treatment experiments were carried out in a quartz tube reactor. Results showed that the release ratio of total mercury during thermal decomposition of coals increases with the increasing temperature. The order of the amount of mercury released under the three atmospheres is nitrogen<carbon dioxide<air for all three coals during thermal decomposition. This indicates that air and carbon dioxide can promote the mercury release due to their reactivity with coal. However, the order of amount of elemental mercury released under the three atmospheres is nitrogen>carbon dioxide>air for all three coals. The release behavior of the total mercury under air is independent of the coal type. Under the other two atmospheres the release behavior is distinguished by the coal type.

The catalytic performance of methylation of naphthalene with methanol over SAPO-11 zeolites synthesized with different Si content

Shaoqing Guo,Liangfu Zhao,Xiaoxiao Wang,Fang Guo,Xianxian Wei,Zhenmin Liu,Wei Zhang 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.7

A series of SAPO-11 zeolites with different Si contents were prepared by hydrothermally synthesized method. They were characterized by ICP, XRD, SEM, FT-IR, N2 adsorption-desorption, NH3-TPD and 29Si MAS NMR, and evaluated by the methylation of naphthalene with methanol to 2,6-dimethylnaphthalene (2,6-DMN). According to XRD and SEM results, the crystallinity of SAPO-11 sample increased with increase of the Si content until the SiO2/Al2O3 ratio was up to 0.2. However, a reduction in the crystallinity was observed with further increase of the Si content of the synthesis. N2 adsorption-desorption results showed that all the samples possessed micropores and secondary mesopores. SAPO-11 sample with SiO2/Al2O3 ratio of 0.2 exhibited the largest secondary mesopores size distributions. NH3-TPD and 29Si MAS NMR showed that the Si content was incorporated into the framework affecting not only the acid sites but also the acid strength of SAPO-11. SAPO-11 with SiO2/Al2O3 ratio of 0.2 presented the high catalytic performances for the methylation of naphthalene, which was mainly attributed to the amount of secondary mesopores in the SAPO-11 zeolite.

Dynamic response of curvilinearly stiffened plates under thermal environment

Jingze Liu,Qingguo Fei,Shaoqing Wu,Dahai Zhang,Dong Jiang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.6

An improved finite element modeling method is developed for isotropic curvilinearly stiffened plates under a thermal environment. The existing modeling method for curvilinearly stiffened plates avoids the difficulty of node overlap, which is suitable for plates with different thicknesses. By introducing the influence of temperature on material parameters and thermal stress on additional stiffness, the existing method is improved and extended to the study of thermodynamics. The proposed method is verified by modal test at normal temperature and commercial finite element software at the thermal environment. The variation of dynamic characteristics with temperature under different boundary conditions was studied. Results show that when the boundary conditions are asymmetric, the influence of temperature on the thermal mode shape is more significant than the case of symmetrical.

A Fluorinated Polythiophene Derivative with Stabilized Backbone Conformation for Highly Efficient Fullerene and Non-Fullerene Polymer Solar Cells

Zhang, Shaoqing,Qin, Yunpeng,Uddin, Mohammad Afsar,Jang, Bomee,Zhao, Wenchao,Liu, Delong,Woo, Han Young,Hou, Jianhui American Chemical Society 2016 Macromolecules Vol.49 No.8

<P>Here, taking a polythiophene derivative (PBDD4T) as a starting polymer, we tried to increase the rotation barrier and hence stabilize its backbone conformation by introducing fluorine into the beta and beta'-position of the alpha-linked bithiophene segments and then synthesized a new polymer named as PBDD4T-2F. Our results demonstrate that the rotation barrier between the a-linked bithiophene significantly increases after the fluorination, so PBDD4T-2F has a more stable backbone conformation than PBDD4T. Compared to PBDD4T, PBDD4T-2F shows stronger aggregation effect in solution state and more compact pi-pi stacking in solid thin film and also possesses deeper HOMO level. These properties make PBDD4T-2F being an ideal donor material in PSCs. When blended with PC71BM, a fullerene acceptor, the PBDD4T-2F-based device showed a power conversion efficiency (PCE) of 9.04%, which is 38% higher than that of the PBDD4T-based device; when blended with ITIC, a non-fullerene acceptor, the PBDD4T-2F-based device showed a PCE of 8.69%, which is almost 20 times higher than that of the PBDD4T-based device. What is more, the tandem cell, in which the blend of PBDD4T-2F:PC61BM was used for making the front subcell, exhibited a high PCE of 10.12%. The photovoltaic results indicate that the fluorination is an effective method to enhance interchain pi-pi interaction for the polythiophene and hence to tune its photovoltaic properties in PSCs, especially for the fullerene-free device based on ITIC.</P>

Geochemical baseline and distribution of cobalt, manganese, and vanadium in the Liao River Watershed sediments of China

Chunye Lin,Jing Wang,Shaoqing Liu,Mengchang He,Xitao Liu 한국지질과학협의회 2013 Geosciences Journal Vol.17 No.4

The quantitative contamination assessment of toxic elements in sediments is a challenge due to the lack of their geochemical background or baseline levels and sediment heterogeneity. Eighty-eight sediment samples were collected in the Liao River Watershed (LRW) and analyzed for Co, Mn, V, Sc, Fe, Al, and sediment properties. The average background levels, geochemical baseline levels (GBL), and geochemical baseline functions of Co,Mn, and V in the sediments were obtained using statistical and geochemical methodologies. The concentrations of Co, Mn, and V were 0.86 to 23.40, 105.9 to 1771.6, and 6.47 to 153.30 mg/kg, respectively. The average background levels and GBLs were 7.2 and 14.4mg/kg for Co, 422 and 762 mg/kg for Mn, and 35.4 and 59.0 mg/kg for V. The linear correlation of Co, Mn, and V with particle-size proxy elements (normalizers) Sc, Fe, and Al was statistically significant with probability (p-value) <0.001 level, showing that Fe,Al, and Sc can be used as particle-size proxy elements to develop the GBFs of Co, Mn, and V. The spatial distribution of the sampling sites with the concentrations of Co, Mn, and V either outlied or greater than GBLs may be related to industry and mine distribution,showing the impact of human activities on the contents of Co, Mn, and V in the LRW sediments. The procedure in the study can be used to estimate GBLs and construct GBFs of toxic elements in other watershed sediments on the world in order to manage sediment quality. The quantitative contamination assessment of toxic elements in sediments is a challenge due to the lack of their geochemical background or baseline levels and sediment heterogeneity. Eighty-eight sediment samples were collected in the Liao River Watershed (LRW) and analyzed for Co, Mn, V, Sc, Fe, Al, and sediment properties. The average background levels, geochemical baseline levels (GBL), and geochemical baseline functions of Co,Mn, and V in the sediments were obtained using statistical and geochemical methodologies. The concentrations of Co, Mn, and V were 0.86 to 23.40, 105.9 to 1771.6, and 6.47 to 153.30 mg/kg, respectively. The average background levels and GBLs were 7.2 and 14.4mg/kg for Co, 422 and 762 mg/kg for Mn, and 35.4 and 59.0 mg/kg for V. The linear correlation of Co, Mn, and V with particle-size proxy elements (normalizers) Sc, Fe, and Al was statistically significant with probability (p-value) <0.001 level, showing that Fe,Al, and Sc can be used as particle-size proxy elements to develop the GBFs of Co, Mn, and V. The spatial distribution of the sampling sites with the concentrations of Co, Mn, and V either outlied or greater than GBLs may be related to industry and mine distribution,showing the impact of human activities on the contents of Co, Mn, and V in the LRW sediments. The procedure in the study can be used to estimate GBLs and construct GBFs of toxic elements in other watershed sediments on the world in order to manage sediment quality.