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Recent Developments in the Use of Intralesional Injections Keloid Treatment
Perdanasari, Aurelia Trisliana,Lazzeri, Davide,Su, Weijie,Xi, Wenjing,Zheng, Zhang,Ke, Li,Min, Peiru,Feng, Shaoqing,Zhang, Yixin,Persichetti, Paolo Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.6
Keloid scars are often considered aesthetically unattractive and frustrating problems that occur following injuries. They cause functional and cosmetic deformities, displeasure, itching, pain, and psychological stress and possibly affect joint movement. The combination of these factors ultimately results in a compromised quality of life and diminished functional performance. Various methods have been implemented to improve keloid scars using both surgical and non-surgical approaches. However, it has proven to be a challenge to identify a universal treatment that can deliver optimal results for all types of scars. Through a PubMed search, we explored most of the literature that is available about the intralesional injection treatment of hypertrophic scars and keloids and highlights both current (corticosteroid, 5-fluorouracil, bleomycin, interferon, cryotherapy and verapamil) and future treatments (interleukin-10 and botulinum toxin type A). The reference lists of retrieved articles were also analysed. Information was gathered about the mechanism of each injection treatment, its benefits and associated adverse reactions, and possible strategies to address adverse reactions to provide reliable guidelines for determining the optimal treatment for particular types of keloid scars. This article will benefit practitioners by outlining evidence-based treatment strategies using intralesional injections for patients with hypertrophic scars and keloids.
Recent Developments in the Use of Intralesional Injections Keloid Treatment
Aurelia Trisliana Perdanasari,Davide Lazzeri,Weijie Su,Wenjing Xi,Zhang Zheng,Li Ke,Peiru Min,Shaoqing Feng,Yixin Zhang,Paolo Persichetti 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.6
Keloid scars are often considered aesthetically unattractive and frustrating problems thatoccur following injuries. They cause functional and cosmetic deformities, displeasure, itching,pain, and psychological stress and possibly affect joint movement. The combination of thesefactors ultimately results in a compromised quality of life and diminished functionalperformance. Various methods have been implemented to improve keloid scars using bothsurgical and non-surgical approaches. However, it has proven to be a challenge to identify auniversal treatment that can deliver optimal results for all types of scars. Through a PubMedsearch, we explored most of the literature that is available about the intralesional injectiontreatment of hypertrophic scars and keloids and highlights both current (corticosteroid,5-fluorouracil, bleomycin, interferon, cryotherapy and verapamil) and future treatments(interleukin-10 and botulinum toxin type A). The reference lists of retrieved articles were alsoanalysed. Information was gathered about the mechanism of each injection treatment, itsbenefits and associated adverse reactions, and possible strategies to address adverse reactionsto provide reliable guidelines for determining the optimal treatment for particular types ofkeloid scars. This article will benefit practitioners by outlining evidence-based treatmentstrategies using intralesional injections for patients with hypertrophic scars and keloids.