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An Seungwon,Nedumaran Balachandar,Koh Hong,Joo Dong Jin,Lee Hyungjo,Park Chul-Seung,Harris Robert A.,Shin Keong Sub,Djalilian Ali R.,Kim Yong Deuk 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Melatonin is involved in the regulation of various biological functions. Here, we explored a novel molecular mechanism by which the melatonin-induced sestrin2 (SESN2)-small heterodimer partner (SHP) signaling pathway protects against fasting- and diabetes-mediated hepatic glucose metabolism. Various key gene expression analyses were performed and multiple metabolic changes were assessed in liver specimens and primary hepatocytes of mice and human participants. The expression of the hepatic cereblon (CRBN) and b-cell translocation gene 2 (BTG2) genes was significantly increased in fasting mice, diabetic mice, and patients with diabetes. Overexpression of Crbn and Btg2 increased hepatic gluconeogenesis by enhancing cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CREBH), whereas this phenomenon was prominently ablated in Crbn null mice and Btg2-silenced mice. Interestingly, melatonin-induced SESN2 and SHP markedly reduced hepatic glucose metabolism in diabetic mice and primary hepatocytes, and this protective effect of melatonin was strikingly reversed by silencing Sesn2 and Shp. Finally, the melatonin-induced SESN2-SHP signaling pathway inhibited CRBN- and BTG2-mediated hepatic gluconeogenic gene transcription via the competition of BTG2 and the interaction of CREBH. Mitigation of the CRBN-BTG2-CREBH axis by the melatonin-SESN2-SHP signaling network may provide a novel therapeutic strategy to treat metabolic dysfunction due to diabetes.
Evaluation of Field Application of Porous Cement-Treated Base Course for Airport Pavement
Seungwon Kim,Yongjae Kim,Haekook Jung,In Tai Kim,Cheolwoo Park 한국도로학회 2018 한국도로학회 학술대회 발표논문 초록집 Vol.2018 No.05
The current construction and maintenance guidelines applied to airport pavement in Korea are those of the International Civil Aviation Organization (ICAO), the International Air Transport Association (IATA), and the Federal Aviation Administration (FAA). In order to consider local conditions of airports in Korea, more specific details should be addressed in those guidelines. For example, the design and construction for pavements at airports in Korea follow the specifications of materials for general roads or foreign airport pavement guidelines, as there is no design manual or guideline for the granular base and subbase materials for airport pavement in Korea. In such circumstances, the likelihood of premature failure or accelerated damage increases, as the loading from airplanes is not fully taken into account or the local environmental characteristics are not considered. In addition, concerns in public facility drainage systems have been rising recently in line with the increase in the frequency and scale, caused by the global abnormal-temperature phenomenon, of localized torrential rain and snow. For airport runways, measures to maintain swift drainage systems are especially necessary to ensure safety and prevent flight delays. In this study, the appropriate moisture content and pavement method are analyzed by applying porous concrete developed for a cement-treated base course for securing permeability of airport pavement at an actual construction site. In addition, on-site construction testing was performed to determine the appropriate compaction method and the curing method to minimize cracking by using a compaction facility. To determine the optimal moisture content, a quality-control was performed by measuring the moisture content of porous concrete produced at a batch plant. For this purpose, a speed moisture test (ASTM D 4944) was performed on site because the unit-water content of the porous concrete affects its compaction and finishing. Before compaction, a grader was used to remove fragments on the subbase and then a tandem roller was used to level and compact. After compaction, the porous cement-treated base course, called porous concrete, was placed using an asphalt finisher. The mechanical properties and durability of the porous cement-treated base course with a variation of a degree of compaction: noncompaction, tandem roller moved back and forth once, three times, and five times. The pavement was covered with vinyl according to the curing guidelines suggested by the Korea Expressway Corporation’s highway construction specifications, to prevent evaporation from porous concrete that has relatively low moisture content. After curing, the core was collected to analyze the compressive strength, permeability coefficient, porosity, and freeze–thaw resistance characteristics.
Lee, Seungwon,Kim, Hyekang,You, Gihoon,Kim, Young-Min,Lee, Seunghun,Le, Viet-Hoan,Kwon, Ohseop,Im, Sin-Hyeog,Kim, You-Me,Kim, Kwang Soon,Sung, Young Chul,Kim, Ki Hean,Surh, Charles D.,Park, Yunji,Lee, American Society of Hematology 2019 Blood Vol.134 No.16
<B>Abstract</B><P>Lee and colleagues investigated the role of the intestinal microbiota in steady-state hematopoieisis, demonstrating that microbiota-derived DNA circulates to the bone marrow, where uptake by mononuclear cells leads to inflammatory cytokine production favoring myeloid-cell maturation of hematopoietic progenitors.</P>
황화수소 산화 촉매의 활성금속 함량 및 온도에 따른 반응 특성 연구
김준오(Jun Oh Kim),장영희(Younghee Jang),이예환(Ye Hwan Lee),정현수(Hyeonsu Jeong),최승원(Seungwon Choi),변성제(Seongje Byun),김재헌(Jaeheon Kim),김재헌(Junghyun Kim),이상문(Sang Moon Lee),김성수(Sung Su Kim) 유기성자원학회 2022 유기성자원학회 학술발표대회논문집 Vol.2022 No.추계
대표적 악취물질인 황화수소(Hydrogen sulfide, H2S)는 주로 석유정제공정이나 다양한 화학공정에서 발생되며, 인체 접촉시 신경계 영향, 질식으로 인한 사망과 같은 영향을 미치게 된다. 이를 제어하기 위해 흡착법, 촉매산화법 등이 이용된다. 흡착법은 대부분의 산업 공정에 적용할 수 있으나 2차폐기물 발생과 황화수소를 선택적으로 제어하는 것이 아니라는 문제점이 있다. 촉매 산화는 촉매를이용하여 황화수소를 선택적으로 산화하는 방법으로 흡착법의 한계를 극복할 수 있다는 장점이 있다. 본 연구에서는 황화수소를 산화하기 위해 V/TiO2 촉매를 제조하여 활성 및 특성을 평가하였다. 활성금속 함량을 달리하여 촉매를 제조하였으며 함량이 증가 할수록 활성이 증가하는 경향을 보였으나 20 wt% 이상에서 활성이 감소하는 것을 확인하였다. BET 분석 결과 바나듐 함량이 증가할수록비표면적이 감소됨을 확인하였다. 10V/TiO2 촉매에 대해 온도에 따른 산화 실험을 수행하였으며, 50 ℃이상일 경우 촉매 비활성화가 확인되었다. 활성 감소 원인을 확인하기 위해 SEM, EDS 및 XRD 분석을 수행하였다. 그 결과, EDS 분석에서 촉매 표면에 황이 생성되었고, XRD에서 peak가 감소한것을 확인하였다. 따라서 황화수소 산화촉매 제어시설에는 황을 배출할 수 있는 재생공정이 필요한것으로 판단된다.
악취 제어를 위한 활성탄 흡착탑의 최적 유동특성 선정 연구
김준오(Jun Oh Kim),장영희(Younghee Jang),이예환(Ye Hwan Lee),정현수(Hyeonsu Jeong),최승원(Seungwon Choi),변성제(Seongje Byun),김재헌(Jaeheon Kim),김정현(Junghyun Kim),이상문(Sang Moon Lee),김성수(Sung Su Kim) 유기성자원학회 2022 유기성자원학회 학술발표대회논문집 Vol.2022 No.추계
악취물질은 환경오염물질 중 감각공해물질로 불쾌감을 주는 오염물질이다. 다양한 환경 공정에서 발생하는 악취물질 및 대기오염물질은 인체에 고농도로 노출될 경우 유해한 영향을 미치게 되므로 제어가 필요하다. 대표적인 제어 방법인 흡착법은 부하에 대한 유연성과 높은 비표면적을 갖는활성탄을 주로 이용하고 있다. 그러나 탈착물을 포함한 2차 오염물의 발생과 과도한 압력손실, 높은분진 발생과 같은 문제가 있으므로 흡착탑의 효율 극대화를 위해 압력손실을 최소화하고 높은 접촉면적을 갖는 최적 운전조건을 선정해야 한다. 이에 따라 본 연구에서는 슬러지 건조 과정에서 발생할수 있는 악취를 제어하기 위해 흡착탑의 유동분석을 수행하였다. 활성탄별 압력손실 특성을 분석한결과, 특정 크기와 모양을 가질 때 가장 낮은 압력 손실을 가졌으며, 원통형 조립이 각형 활성탄 대비약 28% 감소하였다. 따라서 활성탄이 2~4 mesh 크기와 불규칙한 모양을 가질 때 우수한 효율과 경제성을 갖는 흡착탑을 설계할 수 있을 것으로 판단된다.
Individualized Acupuncture for Symptom Relief in Functional Dyspepsia: A Randomized Controlled Trial
Ko, Seok-Jae,Kuo, Braden,Kim, Seul-Ki,Lee, Hyangsook,Kim, Jinsung,Han, Gajin,Kim, Juyeon,Kim, Song-Yi,Jang, Seungwon,Son, Jiyoung,Kim, Minji,Lee, Hyejung,Yeo, Inkwon,Joo, Kwang Ro,Park, Jae-Woo Mary Ann Liebert 2016 Journal of Alternative & Complementary Medicine Vol.22 No.12