http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Myoung-Hwan,Choi, Jeonghoon,Yang, Jinhee,Chung, Woosuk,Kim, Ji-Hyun,Paik, Sang Kyoo,Kim, Karam,Han, Seungnam,Won, Hyejung,Bae, Young-Soo,Cho, Suk-Hee,Seo, Jinsoo,Bae, Yong Chul,Choi, Se-Young,Kim The Society 2009 The Journal of neuroscience Vol.29 No.5
<P>IRSp53 is an adaptor protein that acts downstream of Rac and Cdc42 small GTPases and is implicated in the regulation of membrane deformation and actin filament assembly. In neurons, IRSp53 is an abundant postsynaptic protein and regulates actin-rich dendritic spines; however, its in vivo functions have not been explored. We characterized transgenic mice deficient of IRSp53 expression. Unexpectedly, IRSp53(-/-) neurons do not show significant changes in the density and ultrastructural morphologies of dendritic spines. Instead, IRSp53(-/-) neurons exhibit reduced AMPA/NMDA ratio of excitatory synaptic transmission and a selective increase in NMDA but not AMPA receptor-mediated transmission. IRSp53(-/-) hippocampal slices show a markedly enhanced long-term potentiation (LTP) with no changes in long-term depression. LTP-inducing theta burst stimulation enhances NMDA receptor-mediated transmission. Spatial learning and novel object recognition are impaired in IRSp53(-/-) mice. These results suggest that IRSp53 is involved in the regulation of NMDA receptor-mediated excitatory synaptic transmission, LTP, and learning and memory behaviors.</P>
Development of the Beamline Front End at the Pohang Light Source(PLS)-II
Myeongjin Kim,Chasun Lee,Seonghan Kim,Hiseob Kim,Chungil Ryu,Induk Seo,Seungnam Kim 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.8
The third-generation synchrotron radiation accelerator has been providing beams to users since 1995 and have been made to upgrade the performances of the accelerators and the experimental devices. For that reason, the PLS-II was started in 2009 as a three-year project. An important feature is the extension of the ID (insertion device) beamline and the ecient placement of the storage ring magnet structure. The overall structure of the beamline as well as the length and structure of the front end had to be changed to expand the ID beamline. Also, the safety of many vacuum parts that would be exposed to the large heat due to the increase in the beam energy was rstly considered in the design, and an analysis was performed in parallel. This paper describes the overall structure of the front end, including the design and analysis of the vacuum components in the Pohang Light Source(PLS)-II beamline.
Han, Seungnam,Nam, Jungyong,Li, Yan,Kim, Seho,Cho, Suk-Hee,Cho, Yi Sul,Choi, So-Yeon,Choi, Jeonghoon,Han, Kihoon,Kim, Youngrim,Na, Moonseok,Kim, Hyun,Bae, Yong Chul,Choi, Se-Young,Kim, Eunjoon The Society 2010 The Journal of neuroscience Vol.30 No.45
<P>PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. Overexpression of TANC1 and TANC2 in cultured neurons increases the density of dendritic spines and excitatory synapses in a manner that requires the PDZ (PSD-95/Dlg/ZO-1)-binding C termini of TANC proteins. TANC1-deficient mice exhibit reduced spine density in the CA3 region of the hippocampus, but not in the CA1 or dentate gyrus regions, and show impaired spatial memory. TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development.</P>
A Self-Biased Current-Mode Amplifier With an Application to 10-bit Pipeline ADC
Seungnam Choi,Yunjae Suh,Joohyun Lee,Jinkyu Kim,Byungsub Kim,Hong-June Park,Jae-Yoon Sim IEEE 2017 IEEE Transactions on Circuits and Systems I: Regul Vol.64 No.7
<P>This paper presents a self-biased current-mode amplifier (CMAMP) suitable for a switched-capacitor circuit. The CMAMP uses a subthreshold-biased transimpedance stage as a current-sensing load, and minimizes static power dissipation by passing bias current only at the input stage. The first-order system behavior with single dominant pole gives stable phase margin without complicated frequency compensation. Self-biasing circuits automatically generate bias voltages to sustain performance over a wide range of supply voltage. The designed CMAMP is verified in a 10-bit pipeline analog-to-digital converter (ADC) fabricated in a 65-nm CMOS process. The ADC achieves a figure of merit of 14.3 fJ/c-s with a supply voltage of 0.6 V at 2.5 MS/s.</P>